Kenneth Ward Lyles, MD

Professor of Medicine
Senior Fellow in the Center for the Study of Aging and Human Development
Campus mail Duke Box 3881, Durham, NC 27710
Phone (919) 660-7520
Email address kenneth.lyles@duke.edu

My research activities focus on understanding ways that osteoporotic fractures affect people and trying to learn ways to reduce their impact on affected individuals and prevent further fractures. I have worked with patient with hip and vertebral fractures, gaining insight into the impairments such fractures cause. Also we have learned that a hip fracture is a major risk factor for subsequent fractures after the initial hip fracture. Our group completed a randomized, placebo-controlled trial that we designed with Novartis Pharmaceutical Corporation showing, that an annual infusion of a 5mg of the bisphosphonate zoledronic acid reduced subsequent fractures after a surgical procedure for a hip fracture by 35% when compared to a place infusion (New England Journal of Medicine, 11-1-07). In this study we also observed a 28% reduction in death in the zoledronic acid treated patients. Other research groups have shown that oral bisphosphonates also reduce mortality in patients with osteoporosis. Currently, we, with a number of collaborators, are conducting both animal and human studies to better understand this beneficial effect upon mortality.

In other work, our group tries to understand how other diseases such as strokes and spinal cord injury, and medications such as anticonvulsants place patients at risk for fractures. As we understand the epidemiology of these types of fractures, we plan to develop intervention trials to test whether we can reduce the occurrence of these fractures.

In addition to the above described work our group has help design and conduct a number of phase 1,2 and 3 clinical trials in Paget's disease of Bone and osteoporosis.

KEY WORDS:
Oteoporosis
Hip and vertebra fractures
Paget's disease of bone
Mobility impairments from metabolic bone diseases
Bisphosphonates

Education and Training

  • M.D., Virginia Commonwealth University, 1974

Publications

Siris, ES, Lyles, KW, Singer, FR, and Meunier, PJ. "Medical management of Paget's disease of bone: Indications for treatment and review of current therapies." Journal of Bone and Mineral Research 22, no. SUPPL. 2 (2007): P94-P98.

PMID
17229018
Full Text

Whitson, HE, Lobaugh, B, and Lyles, KW. "Severe hypocalcemia following bisphosphonate treatment in a patient with Paget's disease of bone." Bone 39, no. 4 (October 2006): 954-958.

PMID
16769264
Full Text

Whitson, HE, Pieper, CF, Sanders, L, Horner, RD, Duncan, PW, and Lyles, KW. "Adding injury to insult: fracture risk after stroke in veterans." J Am Geriatr Soc 54, no. 7 (July 2006): 1082-1088.

PMID
16866679
Full Text

Levine, DA, Saag, KG, Casebeer, LL, Colon-Emeric, C, Lyles, KW, and Shewchuk, RM. "Using a Modified Nominal Group Technique to Elicit Director of Nursing Input for an Osteoporosis Intervention." Journal of the American Medical Directors Association 7, no. 7 (2006): 420-425.

PMID
16979085
Full Text

Siris, ES, Lyles, KW, Singer, FR, and Meunier, PJ. "Medical management of Paget's disease of bone: Indications for treatment and review of current therapies." Journal of Bone and Mineral Research 21, no. SUPPL. 2 (2006): P94-P98.

Full Text

Stone, LM, and Lyles, KW. "Osteoporosis in later life." Generations 30, no. 3 (2006): 65-70.

Scholars@Duke

Reid, IR, Miller, P, Lyles, K, Fraser, W, Brown, JP, Saidi, Y, Mesenbrink, P, Su, G, Pak, J, Zelenakas, K, Luchi, M, Richardson, P, and Hosking, D. "Comparison of a single infusion of zoledronic acid with risedronate for Paget's disease." The New England Journal of Medicine 353, no. 9 (September 2005): 898-908.

PMID
16135834
Full Text

Colón-Emeric, CS, and Lyles, KW. "Antiresorptive pharmacotherapy in older women: where the evidence-based medicine rubber meets the geriatrics road." J Am Geriatr Soc 53, no. 8 (August 2005): 1425-1426.

PMID
16078974
Full Text

Colón-Emeric, CS, Casebeer, L, Saag, K, Allison, J, Levine, D, Suh, TT, and Lyles, KW. "Barriers to providing osteoporosis care in skilled nursing facilities: Perceptions of medical directors and directors of nursing." Journal of the American Medical Directors Association 6, no. 3 SUPPL. (2005): S60-S66.

Full Text

Ichikawa, S, Lyles, KW, and Econs, MJ. "Rapid communication: A novel GALNT3 mutation in a pseudoautosomal dominant form of tumoral calcinosis: Evidence that the disorder is autosomal recessive." Journal of Clinical Endocrinology and Metabolism 90, no. 4 (2005): 2420-2423.

PMID
15687324
Full Text

Pages