Kenneth Ward Lyles, MD

Professor of Medicine
Senior Fellow in the Center for the Study of Aging and Human Development
Campus mail Duke Box 3881, Durham, NC 27710
Phone (919) 660-7520
Email address kenneth.lyles@duke.edu

My research activities focus on understanding ways that osteoporotic fractures affect people and trying to learn ways to reduce their impact on affected individuals and prevent further fractures. I have worked with patient with hip and vertebral fractures, gaining insight into the impairments such fractures cause. Also we have learned that a hip fracture is a major risk factor for subsequent fractures after the initial hip fracture. Our group completed a randomized, placebo-controlled trial that we designed with Novartis Pharmaceutical Corporation showing, that an annual infusion of a 5mg of the bisphosphonate zoledronic acid reduced subsequent fractures after a surgical procedure for a hip fracture by 35% when compared to a place infusion (New England Journal of Medicine, 11-1-07). In this study we also observed a 28% reduction in death in the zoledronic acid treated patients. Other research groups have shown that oral bisphosphonates also reduce mortality in patients with osteoporosis. Currently, we, with a number of collaborators, are conducting both animal and human studies to better understand this beneficial effect upon mortality.

In other work, our group tries to understand how other diseases such as strokes and spinal cord injury, and medications such as anticonvulsants place patients at risk for fractures. As we understand the epidemiology of these types of fractures, we plan to develop intervention trials to test whether we can reduce the occurrence of these fractures.

In addition to the above described work our group has help design and conduct a number of phase 1,2 and 3 clinical trials in Paget's disease of Bone and osteoporosis.

KEY WORDS:
Oteoporosis
Hip and vertebra fractures
Paget's disease of bone
Mobility impairments from metabolic bone diseases
Bisphosphonates

Education and Training

  • M.D., Virginia Commonwealth University, 1974

Publications

Cohen, HJ, Feussner, JR, Weinberger, M, Carnes, M, Hamdy, RC, Hsieh, F, Phibbs, C, Courtney, D, Lyles, KW, May, C, McMurtry, C, Pennypacker, L, Smith, DM, Ainslie, N, Hornick, T, Brodkin, K, and Lavori, P. "A controlled trial of inpatient and outpatient geriatric evaluation and management." The New England Journal of Medicine 346, no. 12 (March 2002): 905-912.

PMID
11907291
Full Text

van Staa, TP, Selby, P, Leufkens, HG, Lyles, K, Sprafka, JM, and Cooper, C. "Incidence and natural history of Paget's disease of bone in England and Wales." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research 17, no. 3 (March 2002): 465-471.

PMID
11878305
Full Text

Lyles, KW, Siris, ES, Singer, FR, and Meunier, PJ. "A clinical approach to diagnosis and management of Paget's disease of bone." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research 16, no. 8 (August 2001): 1379-1387. (Review)

PMID
11499860
Full Text

Jayaraj, K, Martinez, S, Freeman, A, and Lyles, KW. "Intraosseous meningioma--a mimicry of Paget's disease?." J Bone Miner Res 16, no. 6 (June 2001): 1154-1156.

PMID
11393793
Full Text

Lyles, KW, Siris, ES, Singer, FR, and Meunier, PJ. "Guidelines for the diagnosis and therapy of the Paget's disease of the bone." Revista Espanola De Enfermedades Metabolicas Oseas 10, no. 1 (January 1, 2001): 28-34.

Scholars@Duke

Lyles, KW. "Osteoporosis and depression: Shedding more light upon a complex relationship." Journal of the American Geriatrics Society 49, no. 6 (2001): 827-828.

PMID
11454124
Full Text

Colón-Emeric, C, Yballe, L, Sloane, R, Pieper, CF, and Lyles, KW. "Expert physician recommendations and current practice patterns for evaluating and treating men with osteoporotic hip fracture." Journal of the American Geriatrics Society 48, no. 10 (October 2000): 1261-1263.

PMID
11037013
Full Text

Colón-Emeric, CS, Sloane, R, Hawkes, WG, Magaziner, J, Zimmerman, SI, Pieper, CF, and Lyles, KW. "The risk of subsequent fractures in community-dwelling men and male veterans with hip fracture." The American Journal of Medicine 109, no. 4 (September 2000): 324-326.

PMID
10996584
Full Text

Nance, MA, Nuttall, FQ, Econs, MJ, Lyles, KW, Viles, KD, Vance, JM, Pericak-Vance, MA, and Speer, MC. "Heterogeneity in Paget disease of the bone." Am J Med Genet 92, no. 5 (June 19, 2000): 303-307.

PMID
10861657
Scholars@Duke

Shipp, KM, Purse, JL, Gold, DT, Pieper, CF, Sloane, R, Schenkman, M, and Lyles, KW. "Timed loaded standing: a measure of combined trunk and arm endurance suitable for people with vertebral osteoporosis." Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the Usa 11, no. 11 (January 2000): 914-922.

PMID
11193243
Full Text

Pages