Kevin J Wiehe, PhD

Publications

Luo, Kan, Hua-Xin Liao, Ruijun Zhang, David Easterhoff, Kevin Wiehe, Thaddeus C. Gurley, Lawrence C. Armand, et al. “Tissue memory B cell repertoire analysis after ALVAC/AIDSVAX B/E gp120 immunization of rhesus macaques.” Jci Insight 1, no. 20 (December 8, 2016): e88522. https://doi.org/10.1172/jci.insight.88522.

PMID
27942585
Full Text

Zhang, Ruijun, Laurent Verkoczy, Kevin Wiehe, S. Munir Alam, Nathan I. Nicely, Sampa Santra, Todd Bradley, et al. “Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages.” Sci Transl Med 8, no. 336 (April 27, 2016): 336ra62. https://doi.org/10.1126/scitranslmed.aaf0618.

PMID
27122615
Full Text

Bonsignori, Mattia, Tongqing Zhou, Zizhang Sheng, Lei Chen, Feng Gao, M Gordon Joyce, Gabriel Ozorowski, et al. “Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody.” Cell 165, no. 2 (April 7, 2016): 449–63. https://doi.org/10.1016/j.cell.2016.02.022.

PMID
26949186
Full Text

Jeffries, T. L., C. R. Sacha, J. Pollara, J. Himes, F. H. Jaeger, S. M. Dennison, E. McGuire, et al. “The function and affinity maturation of HIV-1 gp120-specific monoclonal antibodies derived from colostral B cells.” Mucosal Immunol 9, no. 2 (March 2016): 414–27. https://doi.org/10.1038/mi.2015.70.

PMID
26242599
Full Text

Williams, Wilton B., Hua-Xin Liao, M Anthony Moody, Thomas B. Kepler, S Munir Alam, Feng Gao, Kevin Wiehe, et al. “HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies.” Science 349, no. 6249 (August 14, 2015): aab1253. https://doi.org/10.1126/science.aab1253.

PMID
26229114
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Nicely, Nathan I., Kevin Wiehe, Thomas B. Kepler, Frederick H. Jaeger, S Moses Dennison, Supachai Rerks-Ngarm, Sorachai Nitayaphan, et al. “Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee.” Ebiomedicine 2, no. 7 (July 2015): 713–22. https://doi.org/10.1016/j.ebiom.2015.06.016.

PMID
26288844
Full Text

Liu, Mengfei, Guang Yang, Kevin Wiehe, Nathan I. Nicely, Nathan A. Vandergrift, Wes Rountree, Mattia Bonsignori, et al. “Polyreactivity and autoreactivity among HIV-1 antibodies.” J Virol 89, no. 1 (January 2015): 784–98. https://doi.org/10.1128/JVI.02378-14.

PMID
25355869
Full Text

Wiehe, Kevin, David Easterhoff, Kan Luo, Nathan I. Nicely, Todd Bradley, Frederick H. Jaeger, S Moses Dennison, et al. “Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved.” Immunity 41, no. 6 (December 18, 2014): 909–18. https://doi.org/10.1016/j.immuni.2014.11.014.

PMID
25526306
Full Text

Trama, Ashley M., M Anthony Moody, S Munir Alam, Frederick H. Jaeger, Bradley Lockwood, Robert Parks, Krissey E. Lloyd, et al. “HIV-1 envelope gp41 antibodies can originate from terminal ileum B cells that share cross-reactivity with commensal bacteria.” Cell Host Microbe 16, no. 2 (August 13, 2014): 215–26. https://doi.org/10.1016/j.chom.2014.07.003.

PMID
25121750
Full Text

Pierce, Brian G., Kevin Wiehe, Howook Hwang, Bong-Hyun Kim, Thom Vreven, and Zhiping Weng. “ZDOCK server: interactive docking prediction of protein-protein complexes and symmetric multimers.” Bioinformatics 30, no. 12 (June 15, 2014): 1771–73. https://doi.org/10.1093/bioinformatics/btu097.

PMID
24532726
Full Text

Pages