Kevin O'Neil Saunders, PhD

Assistant Professor of Surgery
Member of the Duke Human Vaccine Institute
Campus mail 2 Genome Court, 3015 Medical Science Research Building 2, Durham, NC 27710
Phone (919) 684-1503
Email address kevin.saunders@duke.edu

Education and Training

  • Ph.D., Duke University, 2010

Publications

Bradley, T, Pollara, J, Santra, S, Vandergrift, N, Pittala, S, Bailey-Kellogg, C, Shen, X, Parks, R, Goodman, D, Eaton, A, Balachandran, H, Mach, LV, Saunders, KO, Weiner, JA, Scearce, R, Sutherland, LL, Phogat, S, Tartaglia, J, Reed, SG, Hu, S-L, Theis, JF, Pinter, A, Montefiori, DC, Kepler, TB, Peachman, KK, Rao, M, Michael, NL, Suscovich, TJ, Alter, G, Ackerman, ME, Moody, MA, Liao, H-X, Tomaras, G, Ferrari, G, Korber, BT, and Haynes, BF. "Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge." Nature communications 8 (June 8, 2017): 15711-.

PMID
28593989
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Bonsignori, M, Kreider, EF, Fera, D, Meyerhoff, RR, Bradley, T, Wiehe, K, Alam, SM, Aussedat, B, Walkowicz, WE, Hwang, K-K, Saunders, KO, Zhang, R, Gladden, MA, Monroe, A, Kumar, A, Xia, S-M, Cooper, M, Louder, MK, McKee, K, Bailer, RT, Pier, BW, Jette, CA, Kelsoe, G, Williams, WB, Morris, L, Kappes, J, Wagh, K, Kamanga, G, Cohen, MS, Hraber, PT, Montefiori, DC, Trama, A, Liao, H-X, Kepler, TB, Moody, MA, Gao, F, Danishefsky, SJ, Mascola, JR, Shaw, GM, Hahn, BH, Harrison, SC, and Korber, BT et al. "Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies." Science translational medicine 9, no. 381 (March 2017).

PMID
28298420
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Alam, SM, Aussedat, B, Vohra, Y, Meyerhoff, RR, Cale, EM, Walkowicz, WE, Radakovich, NA, Anasti, K, Armand, L, Parks, R, Sutherland, L, Scearce, R, Joyce, MG, Pancera, M, Druz, A, Georgiev, IS, Von Holle, T, Eaton, A, Fox, C, Reed, SG, Louder, M, Bailer, RT, Morris, L, Abdool-Karim, SS, Cohen, M, Liao, H-X, Montefiori, DC, Park, PK, Fernández-Tejada, A, Wiehe, K, Santra, S, Kepler, TB, Saunders, KO, Sodroski, J, Kwong, PD, Mascola, JR, Bonsignori, M, Moody, MA, Danishefsky, S, and Haynes, BF. "Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide." Science translational medicine 9, no. 381 (March 2017).

PMID
28298421
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Easterhoff, D, Moody, MA, Fera, D, Cheng, H, Ackerman, M, Wiehe, K, Saunders, KO, Pollara, J, Vandergrift, N, Parks, R, Kim, J, Michael, NL, O'Connell, RJ, Excler, J-L, Robb, ML, Vasan, S, Rerks-Ngarm, S, Kaewkungwal, J, Pitisuttithum, P, Nitayaphan, S, Sinangil, F, Tartaglia, J, Phogat, S, Kepler, TB, Alam, SM, Liao, H-X, Ferrari, G, Seaman, MS, Montefiori, DC, Tomaras, GD, Harrison, SC, and Haynes, BF. "Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial." PLoS pathogens 13, no. 2 (February 24, 2017): e1006182-.

PMID
28235027
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Saunders, KO, Nicely, NI, Wiehe, K, Bonsignori, M, Meyerhoff, RR, Parks, R, Walkowicz, WE, Aussedat, B, Wu, NR, Cai, F, Vohra, Y, Park, PK, Eaton, A, Go, EP, Sutherland, LL, Scearce, RM, Barouch, DH, Zhang, R, Von Holle, T, Overman, RG, Anasti, K, Sanders, RW, Moody, MA, Kepler, TB, Korber, B, Desaire, H, Santra, S, Letvin, NL, Nabel, GJ, Montefiori, DC, Tomaras, GD, Liao, H-X, Alam, SM, Danishefsky, SJ, and Haynes, BF. "Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates." Cell reports 18, no. 9 (February 2017): 2175-2188.

PMID
28249163
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Saunders, KO, Wang, L, Joyce, MG, Yang, Z-Y, Balazs, AB, Cheng, C, Ko, S-Y, Kong, W-P, Rudicell, RS, Georgiev, IS, Duan, L, Foulds, KE, Donaldson, M, Xu, L, Schmidt, SD, Todd, J-P, Baltimore, D, Roederer, M, Haase, AT, Kwong, PD, Rao, SS, Mascola, JR, and Nabel, GJ. "Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection." Journal of virology 89, no. 16 (August 2015): 8334-8345.

PMID
26041300
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Hulot, SL, Korber, B, Giorgi, EE, Vandergrift, N, Saunders, KO, Balachandran, H, Mach, LV, Lifton, MA, Pantaleo, G, Tartaglia, J, Phogat, S, Jacobs, B, Kibler, K, Perdiguero, B, Gomez, CE, Esteban, M, Rosati, M, Felber, BK, Pavlakis, GN, Parks, R, Lloyd, K, Sutherland, L, Scearce, R, Letvin, NL, Seaman, MS, Alam, SM, Montefiori, D, Liao, H-X, Haynes, BF, and Santra, S. "Comparison of Immunogenicity in Rhesus Macaques of Transmitted-Founder, HIV-1 Group M Consensus, and Trivalent Mosaic Envelope Vaccines Formulated as a DNA Prime, NYVAC, and Envelope Protein Boost." Journal of virology 89, no. 12 (June 2015): 6462-6480.

PMID
25855741
Full Text

Saunders, KO, Pegu, A, Georgiev, IS, Zeng, M, Joyce, MG, Yang, Z-Y, Ko, S-Y, Chen, X, Schmidt, SD, Haase, AT, Todd, J-P, Bao, S, Kwong, PD, Rao, SS, Mascola, JR, and Nabel, GJ. "Sustained Delivery of a Broadly Neutralizing Antibody in Nonhuman Primates Confers Long-Term Protection against Simian/Human Immunodeficiency Virus Infection." Journal of virology 89, no. 11 (June 2015): 5895-5903.

PMID
25787288
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Wu, X, Zhang, Z, Schramm, CA, Joyce, MG, Do Kwon, Y, Zhou, T, Sheng, Z, Zhang, B, O’Dell, S, McKee, K, Georgiev, IS, Chuang, G-Y, Longo, NS, Lynch, RM, Saunders, KO, Soto, C, Srivatsan, S, Yang, Y, Bailer, RT, Louder, MK, Mullikin, JC, Connors, M, Kwong, PD, Mascola, JR, Shapiro, L, Benjamin, B, Blakesley, R, Bouffard, G, Brooks, S, Coleman, H, Dekhtyar, M, Gregory, M, Guan, X, Gupta, J, Han, J, Hargrove, A, Ho, S-L, Legaspi, R, Maduro, Q, Masiello, C, Maskeri, B, McDowell, J, and Montemayor, C et al. "Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection." Cell 161, no. 3 (April 2015): 470-485.

Full Text

Haynes, BF, Saunders, KO, Kelsoe, G, Mascola, JR, and Nabel, GJ. "The Cellular and Molecular Biology of HIV-1 Broadly Neutralizing Antibodies." In Molecular Biology of B Cells: Second Edition, 441-461. December 15, 2014.

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