Lan Mao, MD

Assistant Professor in Medicine
Campus mail 231 Clin Res Lab Bldg, Durham, NC 27710
Phone (919) 668-2530
Email address mao00004@mc.duke.edu

I. Research:
As the director of mouse physiology laboratory, in charge for the all events related with Dr. Howard Rockman's molecular biology laboratory studies needs.
Participate in research in rodents model:
Perform surgery and serve as co-investigator in studies on transgenic mice with heart failure. Develop models of hypertrophy in small animal using micro-surgical techniques (aortic constriction, left ventricular infarction and abdominal aortocaval fistula) and perform a variety physiological studies, obtain and analysis data on hemodynamic study and prepare tissue specimens for father molecular biological study.
Develop and apply surgical techniques for in vivo myocardial function study on small animal, such as, using new developed devices study in vivo mice cardiac function (pressure-volume lop), instrumented mice for conscious blood pressure measure or administration of medicine---carotid artery or gull duck catheterization, and conscious mice echocardiography.
Develop techniques for micro-injection of proteins and vectors in to mouse left ventricle, coronary artery and portal vein.

II. Teaching
10% of time allocated/spent---
Train postdoctoral fellows, visiting scientists and students from all over the world in laboratory procedure involving, including endotracheal intubations, cardiac catheterization, coronary occlusion and intrathoracic/intra-abdominal surgical procedures.
Teach methods of data recording and analysis using laboratory equipments and computer programs, echocardiography apply and measurement.

III. Consultant
Consult and teach microsurgical techniques related on small animals such as, rabbits, rat, hamsters and mice, like mice heart-lung transplantation, portal vein injection and mini-pump implant.
Co-laboratory with large range of Universities and Research Institutes from United States an other countries.

Education and Training

  • M.D., Beijing Medical University (China), 1979

Publications

Xu, Wenjing, Tomasa Barrientos, Lan Mao, Howard A. Rockman, Anthony A. Sauve, and Nancy C. Andrews. “Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart.” Cell Rep 13, no. 3 (October 20, 2015): 533–45. https://doi.org/10.1016/j.celrep.2015.09.023.

PMID
26456827
Full Text

Abraham, Dennis, and Lan Mao. “Cardiac Pressure-Volume Loop Analysis Using Conductance Catheters in Mice.” J Vis Exp, no. 103 (September 17, 2015). https://doi.org/10.3791/52942.

PMID
26436838
Full Text

Pironti, Gianluigi, Ryan T. Strachan, Dennis Abraham, Samuel Mon-Wei Yu, Minyong Chen, Wei Chen, Kenji Hanada, Lan Mao, Lewis J. Watson, and Howard A. Rockman. “Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors.” Circulation 131, no. 24 (June 16, 2015): 2120–30. https://doi.org/10.1161/CIRCULATIONAHA.115.015687.

PMID
25995315
Full Text

Abraham, Dennis M., Teresa E. Lee, Lewis J. Watson, Lan Mao, Gurangad Chandok, Matthew J. Wolf, and Howard A. Rockman. “TREK-1 Modulates Fibrosis & Diastolic Dysfunction Through Activation of Stress-Activated Kinases.” In Circulation, Vol. 130. LIPPINCOTT WILLIAMS & WILKINS, 2014.

Scholars@Duke

Moding, Everett J., Chang-Lung Lee, Katherine D. Castle, Patrick Oh, Lan Mao, Shan Zha, Hooney D. Min, Yan Ma, Shiva Das, and David G. Kirsch. “Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium.” J Clin Invest 124, no. 8 (August 2014): 3325–38. https://doi.org/10.1172/JCI73932.

PMID
25036710
Full Text

Keenan, Jeffrey E., Hagir Sulliman, Allison Ulrich, Lan Mao, and Claude A. Piantadosi. “Cardiomyocyte-Specific Ablation of Nuclear Respiratory Factor 1 in the Mouse Leads to Dysregulation of Mitochondrial Biogenesis, Apoptosis, and Heart Failure.” In Circulation Research, Vol. 115. LIPPINCOTT WILLIAMS & WILKINS, 2014.

Scholars@Duke

Wisler, James, Emily Harris, Michael Raisch, Lan Mao, Jihee Kim, Howard Rockman, and Robert Lefkowitz. “NON-CANONICAL ANGIOTENSIN II TYPE 1A RECEPTOR-MEDIATED, BETA-ARRESTIN2-DEPENDENT SIGNALING CONTRIBUTES TO THORACIC AORTIC ANEURYSM FORMATION IN A MURINE MODEL OF MARFAN SYNDROME.” In Journal of the American College of Cardiology, 63:A2148–A2148. Elsevier BV, 2014. https://doi.org/10.1016/s0735-1097(14)62151-3.

Full Text

Ashton, Jeffrey R., Nicholas Befera, Darin Clark, Yi Qi, Lan Mao, Howard A. Rockman, G Allan Johnson, and Cristian T. Badea. “Anatomical and functional imaging of myocardial infarction in mice using micro-CT and eXIA 160 contrast agent.” Contrast Media Mol Imaging 9, no. 2 (March 2014): 161–68. https://doi.org/10.1002/cmmi.1557.

PMID
24523061
Full Text

Kim, Il-Man, Yongchao Wang, Kyoung-Mi Park, Yaoping Tang, Jian-Peng Teoh, Joseph Vinson, Christopher J. Traynham, et al. “β-arrestin1-biased β1-adrenergic receptor signaling regulates microRNA processing.” Circ Res 114, no. 5 (February 28, 2014): 833–44. https://doi.org/10.1161/CIRCRESAHA.114.302766.

PMID
24334028
Full Text

Santacruz, Lucia, Alejandro Hernandez, Jeffrey Nienaber, Rajashree Mishra, Miguel Pinilla, James Burchette, Lan Mao, Howard A. Rockman, and Danny O. Jacobs. “Normal cardiac function in mice with supraphysiological cardiac creatine levels.” Am J Physiol Heart Circ Physiol 306, no. 3 (February 2014): H373–81. https://doi.org/10.1152/ajpheart.00411.2013.

PMID
24271489
Full Text

Pages