Lan Mao, MD

Assistant Professor in Medicine
Campus mail 231 Clin Res Lab Bldg, Durham, NC 27710
Phone (919) 668-2530
Email address mao00004@mc.duke.edu

I. Research:
As the director of mouse physiology laboratory, in charge for the all events related with Dr. Howard Rockman's molecular biology laboratory studies needs.
Participate in research in rodents model:
Perform surgery and serve as co-investigator in studies on transgenic mice with heart failure. Develop models of hypertrophy in small animal using micro-surgical techniques (aortic constriction, left ventricular infarction and abdominal aortocaval fistula) and perform a variety physiological studies, obtain and analysis data on hemodynamic study and prepare tissue specimens for father molecular biological study.
Develop and apply surgical techniques for in vivo myocardial function study on small animal, such as, using new developed devices study in vivo mice cardiac function (pressure-volume lop), instrumented mice for conscious blood pressure measure or administration of medicine---carotid artery or gull duck catheterization, and conscious mice echocardiography.
Develop techniques for micro-injection of proteins and vectors in to mouse left ventricle, coronary artery and portal vein.

II. Teaching
10% of time allocated/spent---
Train postdoctoral fellows, visiting scientists and students from all over the world in laboratory procedure involving, including endotracheal intubations, cardiac catheterization, coronary occlusion and intrathoracic/intra-abdominal surgical procedures.
Teach methods of data recording and analysis using laboratory equipments and computer programs, echocardiography apply and measurement.

III. Consultant
Consult and teach microsurgical techniques related on small animals such as, rabbits, rat, hamsters and mice, like mice heart-lung transplantation, portal vein injection and mini-pump implant.
Co-laboratory with large range of Universities and Research Institutes from United States an other countries.

Education and Training

  • M.D., Beijing Medical University (China), 1979

Publications

Grotegut, Chad, Lan Mao, R Phillips Heine, Amy Murtha, and Howard Rockman. “748: Mice lacking G protein-coupled receptor kinase 6 (GRK6) exhibit an enhanced uterine contractile phenotype resulting in stillbirth.” In American Journal of Obstetrics and Gynecology, 210:S367–68. Elsevier BV, 2014. https://doi.org/10.1016/j.ajog.2013.10.781.

Full Text

Kim, Il-Man, Yongchao Wang, Kyoung-mi Park, Christopher J. Traynham, Lan Mao, Walter J. Koch, and Howard A. Rockman. “beta-arrestin1-Biased beta 1-adrenergic Receptor Signaling Regulates MicroRNA Processing.” In Circulation Research, Vol. 113. LIPPINCOTT WILLIAMS & WILKINS, 2013.

Scholars@Duke

Yu, Yen-Rei A., Lan Mao, Claude A. Piantadosi, and Michael D. Gunn. “CCR2 deficiency, dysregulation of Notch signaling, and spontaneous pulmonary arterial hypertension.” Am J Respir Cell Mol Biol 48, no. 5 (May 2013): 647–54. https://doi.org/10.1165/rcmb.2012-0182OC.

PMID
23492191
Full Text

Tang, Hao, Kunhong Xiao, Lan Mao, Howard A. Rockman, and Douglas A. Marchuk. “Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction.” J Mol Cell Cardiol 54 (January 2013): 101–11. https://doi.org/10.1016/j.yjmcc.2012.10.004.

PMID
23085512
Full Text

Wang, Yongchao, Corey L. Neal, Weili Zou, Lan Mao, Barbara Williams, and Il-man Kim. “beta-arrestin1 Stimulates the Processing of a Subset of MicroRNAs.” In Circulation Research, 111:E385–E385. LIPPINCOTT WILLIAMS & WILKINS, 2012.

Scholars@Duke

Kim, Ki-Seok, Dennis Abraham, Barbara Williams, Jonathan D. Violin, Lan Mao, and Howard A. Rockman. “β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury.” Am J Physiol Heart Circ Physiol 303, no. 8 (October 15, 2012): H1001–10. https://doi.org/10.1152/ajpheart.00475.2012.

PMID
22886417
Full Text

Tang, Hao, Kunhong Xiao, Lan Mao, Howard A. Rockman, and Douglas A. Marchuk. “Overexpression of Cardiac Troponin I-Interacting Kinase, a Cardiac-Specific MAPKKK, Promotes Cardiac Dysfunction.” In Circulation Research, Vol. 111. LIPPINCOTT WILLIAMS & WILKINS, 2012.

Scholars@Duke

Lee, Chang-Lung, Everett J. Moding, Kyle C. Cuneo, Yifan Li, Julie M. Sullivan, Lan Mao, Iman Washington, et al. “p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice.” Sci Signal 5, no. 234 (July 24, 2012): ra52. https://doi.org/10.1126/scisignal.2002918.

PMID
22827996
Full Text

Piacentino, Valentino, Carmelo A. Milano, Michael Bolanos, Jacob Schroder, Emily Messina, Adam S. Cockrell, Edward Jones, et al. “X-linked inhibitor of apoptosis protein-mediated attenuation of apoptosis, using a novel cardiac-enhanced adeno-associated viral vector.” Hum Gene Ther 23, no. 6 (June 2012): 635–46. https://doi.org/10.1089/hum.2011.186.

PMID
22339372
Full Text

Grotegut, Chad, Lan Mao, Amy Murtha, and Howard Rockman. “G Protein-Coupled Receptor Kinase 6 (GRK6) Knock-Out Mice Exhibit Enhanced Uterine Contractility in Response to Oxytocin Infusion.” In Reproductive Sciences, 19:195A-195A. SAGE PUBLICATIONS INC, 2012.

Scholars@Duke

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