Laurent Karl Verkoczy, PhD

Adjunct Professor in the Department of Medicine
Member of the Duke Human Vaccine Institute
Campus mail 14 Circuit Drive, Research Park Building 3, Suite 112A, Durham, NC 27710
Phone (919) 681-3134

Laurent Verkoczy, PhD is Associate Professor of Medicine and Pathology at Duke University Medical Center. Dr.Verkoczy directs the Laboratory of B-cell Immunoregulation at the Duke Human Vaccine Institute and also serves as a B-cell Focus Investigator in Duke’s Center for HIV/AIDS Vaccine Immunology & Immunogen Discovery (CHAVI-ID) consortium.  He obtained his Ph.D. in Immunology from the University of Toronto in 2000 and completed post-doctoral studies at The Scripps Research Institute in 2005. His lab seeks to identify impediments limiting protective antibody responses against highly variable pathogens like HIV-1 and aims to test novel immunogens/vaccine strategies to overcome such roadblocks. Recently, to develop a focused setting to evaluate the ability of vaccine candidates to generate HIV-1 broadly neutralizing antibody (bnAb) responses, his group has engineered mouse strains carrying individual unmutated precursors of several rare, but well-characterized B-cell lineages capable of eventually producing bnAbs during HIV-1 infection.

Education and Training

  • Ph.D., University of Toronto (Canada), 2000

Publications

Saunders, KO, Verkoczy, LK, Jiang, C, Zhang, J, Parks, R, Chen, H, Housman, M, Bouton-Verville, H, Shen, X, Trama, AM, Scearce, R, Sutherland, L, Santra, S, Newman, A, Eaton, A, Xu, K, Georgiev, IS, Joyce, MG, Tomaras, GD, Bonsignori, M, Reed, SG, Salazar, A, Mascola, JR, Moody, MA, Cain, DW, Centlivre, M, Zurawski, S, Zurawski, G, Erickson, HP, Kwong, PD, Alam, SM, Levy, Y, Montefiori, DC, and Haynes, BF. "Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models." Cell Reports 21, no. 13 (December 2017): 3681-3690.

PMID
29281818
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Williams, WB, Zhang, J, Jiang, C, Nicely, NI, Fera, D, Luo, K, Moody, MA, Liao, H-X, Alam, SM, Kepler, TB, Ramesh, A, Wiehe, K, Holland, JA, Bradley, T, Vandergrift, N, Saunders, KO, Parks, R, Foulger, A, Xia, S-M, Bonsignori, M, Montefiori, DC, Louder, M, Eaton, A, Santra, S, Scearce, R, Sutherland, L, Newman, A, Bouton-Verville, H, Bowman, C, Bomze, H, Gao, F, Marshall, DJ, Whitesides, JF, Nie, X, Kelsoe, G, Reed, SG, Fox, CB, Clary, K, Koutsoukos, M, Franco, D, Mascola, JR, Harrison, SC, Haynes, BF, and Verkoczy, L. "Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations." Nature Communications 8, no. 1 (November 23, 2017): 1732-null.

PMID
29170366
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Wiehe, K, Nicely, NI, Lockwood, B, Kuraoka, M, Anasti, K, Arora, S, Bowman, CM, Stolarchuk, C, Parks, R, Lloyd, KE, Xia, S-M, Duffy, R, Shen, X, Kyratsous, CA, Macdonald, LE, Murphy, AJ, Scearce, RM, Moody, MA, Alam, SM, Verkoczy, L, Tomaras, GD, Kelsoe, G, and Haynes, BF. "Immunodominance of Antibody Recognition of the HIV Envelope V2 Region in Ig-Humanized Mice." Journal of Immunology (Baltimore, Md. : 1950) 198, no. 3 (February 2017): 1047-1055.

PMID
28011932
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Kuraoka, M, Snowden, PB, Nojima, T, Verkoczy, L, Haynes, BF, Kitamura, D, and Kelsoe, G. "BCR and Endosomal TLR Signals Synergize to Increase AID Expression and Establish Central B Cell Tolerance." Cell Reports 18, no. 7 (February 2017): 1627-1635.

PMID
28199836
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Verkoczy, L, Alt, FW, and Tian, M. "Human Ig knockin mice to study the development and regulation of HIV-1 broadly neutralizing antibodies." Immunological reviews 275, no. 1 (January 2017): 89-107. (Review)

PMID
28133799
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Verkoczy, L. "Humanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem." Advances in Immunology 134 (January 2017): 235-352. (Review)

PMID
28413022
Full Text

Bradley, T, Yang, G, Ilkayeva, O, Holl, TM, Zhang, R, Zhang, J, Santra, S, Fox, CB, Reed, SG, Parks, R, Bowman, CM, Bouton-Verville, H, Sutherland, LL, Scearce, RM, Vandergrift, N, Kepler, TB, Moody, MA, Liao, H-X, Alam, SM, McLendon, R, Everitt, JI, Newgard, CB, Verkoczy, L, Kelsoe, G, and Haynes, BF. "HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism." Journal of Immunology (Baltimore, Md. : 1950) 197, no. 12 (December 2016): 4663-4673.

PMID
27849170
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Moody, MA, Pedroza-Pacheco, I, Vandergrift, NA, Chui, C, Lloyd, KE, Parks, R, Soderberg, KA, Ogbe, AT, Cohen, MS, Liao, H-X, Gao, F, McMichael, AJ, Montefiori, DC, Verkoczy, L, Kelsoe, G, Huang, J, Shea, PR, Connors, M, Borrow, P, and Haynes, BF. "Immune perturbations in HIV-1-infected individuals who make broadly neutralizing antibodies." Science Immunology 1, no. 1 (July 29, 2016): aag0851-null.

PMID
28783677
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Finney, JT, Yang, G, Kuraoka, M, Nojima, T, Verkoczy, L, Kitamura, D, Haynes, BF, and Kelsoe, GH. "How Tolerance Shapes the Development of the HIV-1 Broadly Neutralizing Antibody 2F5." May 1, 2016.

Scholars@Duke

Zhang, R, Verkoczy, L, Wiehe, K, Munir Alam, S, Nicely, NI, Santra, S, Bradley, T, Pemble, CW, Zhang, J, Gao, F, Montefiori, DC, Bouton-Verville, H, Kelsoe, G, Larimore, K, Greenberg, PD, Parks, R, Foulger, A, Peel, JN, Luo, K, Lu, X, Trama, AM, Vandergrift, N, Tomaras, GD, Kepler, TB, Moody, MA, Liao, H-X, and Haynes, BF. "Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages." Science Translational Medicine 8, no. 336 (April 2016): 336ra62-null.

PMID
27122615
Full Text

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