Li-Tzy Wu, DSc

Professor in Psychiatry and Behavioral Sciences
Professor in Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Affiliate of the Center for Child and Family Policy
Campus mail Duke Psychiatry, DUMC Box # 11, Durham, NC 27710
Phone (919) 889-9369
Email address

Education/Training: Pre- and post-doctoral training in mental health service research, psychiatric epidemiology (NIMH T32), and addiction epidemiology (NIDA T32) from Johns Hopkins University School of Public Health (Maryland); Fellow of the NIH Summer Institute on the Design and Conduct of Randomized Clinical Trials.

Director: Duke Community Based Substance Use Disorder Research Program.
Research interests: COVID-19, Opioid misuse, Opioid overdose, Opioid use disorder, Opioid addiction prevention and treatment, Pain and addiction, Chronic diseases and substance use disorders, diabetes, pharmacy-based care models and services, medication treatment for opioid use disorder (MOUD), Drug overdose, Polysubstance use and disorders, cannabis, alcohol, tobacco, hallucinogens, stimulants, e-cigarette, SBIRT (substance use Screening, Brief Intervention, Referral to Treatment), EHR-based research and intervention, data science, psychometric analysis (IRT), epidemiology of addictions and comorbidity, behavioral health care integration, health services research (mental health disorders, substance use disorders, chronic diseases), nosology, research design, HIV risk behavior. 

FUNDED Research projects (Principal Investigator [PI], Site PI, or Sub-award PI): 
R03: Substance use/dependence (PI).
R21: Treatment use for alcohol use disorders (PI).
R21: Inhalant use & disorders (PI).
R01: MDMA/hallucinogen use/disorders (PI).
R01: Prescription pain reliever (opioids) misuse and use disorders (PI).
R01: Substance use disorders in adolescents (PI).
R21: CTN Substance use diagnoses & treatment (PI).
R33: CTN Substance use diagnoses & treatment (PI).
R01: Evolution of Psychopathology in the Population (ECA Duke site PI).
R01: Substance use disorders and treatment use among Asian Americans and Pacific Islanders (PI).
UG1: SBIRT in Primary Care (NIDA, PI).
UG1: TAPS Tool, Substance use screening tool validation in primary care (NIDA, PI).
UG1: NIDA CTN Mid-Southern Node (Clinical Trials Network, PI).
UG1: EHR Data Element Study (NIDA, PI).
UG1: Buprenorphine Physician-Pharmacist Collaboration in the Management of Patients With Opioid Use Disorder (NIDA, PI).
PCORI: INSPIRE-Integrated Health Services to Reduce Opioid Use While Managing Chronic Pain (Site PI).
CDC R01: Evaluation of state-mandated acute and post-surgical pain-specific CDC opioid prescribing (Site PI).
Pilot: Measuring Opioid Use Disorders in Secondary Electronic Health Records Data (Carolinas Collaborative Grant: Duke PI).
R21: Developing a prevention model of alcohol use disorder for Pacific Islander young adults (Subaward PI, Investigator).
UG1: Subthreshold Opioid Use Disorder Prevention Trial (NIH HEAL Initiative) (NIDA supplement, CTN-0101, Investigator).
NIDA: A Pilot Study to Permit Opioid Treatment Program Physicians to Prescribe Methadone through Community Pharmacies for their Stable Methadone Patients (NIDA/FRI: Study PI).
UG1: Integrating pharmacy-based prevention and treatment of opioid and other substance use disorders: A survey of pharmacists and stakeholder (NIH HEAL Initiative, NIDA, PI).
UG1: NorthStar Node of the Clinical Trials Network (NIDA, Site PI).
R34: Intervention Development and Pilot Study to Reduce Untreated Native Hawaiian and Pacific Islander Opioid Use Disorders (Subaward PI, Investigator).
UG1: Optimal Policies to Improve Methadone Maintenance Adherence Longterm (OPTIMMAL Study) (NIDA, Site PI).

Education and Training

  • D.Sc., Johns Hopkins University, 1997
  • M.A., State University of New York, New Paltz, 1992


Subica, Andrew M., Erick Guerrero, Nia Aitaoto, Howard B. Moss, Derek Iwamoto, and Li-Tzy Wu. “Hazardous drinking, alcohol use disorders, and need for treatment among Pacific Islander young adults.” Am J Orthopsychiatry 90, no. 5 (2020): 557–66.

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Schranz, Asher J., Li-Tzy Wu, David Wohl, and David L. Rosen. “Readmission After Discharge Against Medical Advice for Persons With Opioid-Associated Infective Endocarditis.” In Circulation, Vol. 140, 2019.


Adam, Angéline, Robert P. Schwartz, Li-Tzy Wu, Geetha Subramaniam, Eugene Laska, Gaurav Sharma, Saima Mili, and Jennifer McNeely. “Electronic self-administered screening for substance use in adult primary care patients: feasibility and acceptability of the tobacco, alcohol, prescription medication, and other substance use (myTAPS) screening tool.” Addict Sci Clin Pract 14, no. 1 (October 15, 2019): 39.

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Wu, Li-Tzy, Elizabeth H. Payne, Kimberly Roseman, Carla Kingsbury, Ashley Case, Casey Nelson, and Robert Lindblad. “Clinical Workflow and Substance Use Screening, Brief Intervention, and Referral to Treatment Data in the Electronic Health Records: A National Drug Abuse Treatment Clinical Trials Network Study.” Egems (Wash Dc) 7, no. 1 (August 1, 2019): 35.

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Mannelli, Paolo, and Li-Tzy Wu. “Commentary on Winhusen et al. (2019): Substance use disorders, chronic diseases, and electronic health records-a paradigm for screening and intervention.” Addiction 114, no. 8 (August 2019): 1471–72.

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Jung, Jin-Gyu, Li-Tzy Wu, Jong-Sung Kim, Eung-Du Kim, and Seok-Joon Yoon. “Relationship between Smoking and Abdominal Aorta Calcification on Computed Tomography.” Korean J Fam Med 40, no. 4 (July 2019): 248–53.

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Park, Ji-Yeun, and Li-Tzy Wu. “Trends and correlates of driving under the influence of alcohol among different types of adult substance users in the United States: a national survey study.” Bmc Public Health 19, no. 1 (May 4, 2019): 509.

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Zhu, He, and Li-Tzy Wu. “Discharge against medical advice from hospitalizations for substance use disorders: The potential impact of the Affordable Care Act.” Drug Alcohol Depend 197 (April 1, 2019): 115–19.

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Mannelli, Paolo, and Li-Tzy Wu. “Clinical epidemiology of substance use disorders: Understanding patterns, sharing knowledge, planning interventions.” Indian J Med Res 149, no. 4 (April 2019): 443–45.

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Campbell, Aimee N. C., Dennis McCarty, Traci Rieckmann, Jennifer McNeely, John Rotrosen, Li-Tzy Wu, and Gavin Bart. “Interpretation and integration of the federal substance use privacy protection rule in integrated health systems: A qualitative analysis.” J Subst Abuse Treat 97 (February 2019): 41–46.

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