Loretta Georgina Que, MD

Professor of Medicine
Campus mail 279 Msrb1, Durham, NC 27710
Phone (919) 681-8551
Email address loretta.que@duke.edu

My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.

Key words: nitrosative defense, lung injury, nitric oxide

Education and Training

  • Pulmonary Fellow, Medicine, Duke University, 1993 - 1996
  • Clinical Instructor, Medicine, Yale University, 1992 - 1993
  • Medical Resident, Medicine, Yale University, 1989 - 1992
  • M.D., University of Chicago, 1989

Grants

Publications

He, M., S. H. Robertson, J. M. Wang, L. G. Que, K. Mahmood, B. Driehuys, and Y. -. C. Huang. “Characterizing The Ventilation Distribution In Healthy Normal Subjects To Establish Robust Quantitative Analysis Of 129xe Mri.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.

Scholars@Duke

Yang, Z., Y. Bochkov, D. R. Voelker, M. W. Foster, and L. G. Que. “A Gsnor Inhibitor Blocks Hrv Infection Of Primary Human Airway Epithelial Cells.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.

Scholars@Duke

Winnica, D. E., H. Grasemann, L. G. Que, B. Freeman, K. Wasil, S. E. Wenzel, and F. Holguin. “L-Citrulline Prevents Asymmetric Di-Methyl Arginine Uncoupling Of Nitric Oxide Synthase In Primary Human Airway Epithelial Cells.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.

Scholars@Duke

Huang, Y. -. C., and L. G. Que. “Clinical Significance Of Isolated Decrease In Single Breath Lung Volume-Total Lung Capacity Ratio (va/tlc).” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.

Scholars@Duke

Ingram, Jennifer L., David Slade, Tony D. Church, Dave Francisco, Karissa Heck, R Wesley Sigmon, Michael Ghio, et al. “Role of Matrix Metalloproteinases-1 and -2 in Interleukin-13-Suppressed Elastin in Airway Fibroblasts in Asthma..” Am J Respir Cell Mol Biol 54, no. 1 (January 2016): 41–50. https://doi.org/10.1165/rcmb.2014-0290OC.

PMID
26074138
Full Text

Ledford, J. G., K. J. Addison, D. C. Francisco, M. W. Foster, D. R. Voelker, L. G. Que, and M. Kraft. “Genetic Variation In Surfactant Protein-A2 Leads To Differential Regulation Of Eosinophil Activities And More Pronounced Eosinophilia In Asthmatics.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.

Scholars@Duke

Wang, Y., J. G. Ledford, M. Ghio, D. C. Francisco, K. Addison, L. G. Que, J. W. Hollingsworth, and M. Kraft. “Surfactant Protein A Inhibits Il-13-Induced Inflammatory Response And Mucin Production In Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.

Scholars@Duke

Ledford, J. G., N. Lugogo, N. Agada, J. Weiss, D. C. Francisco, J. L. Ingram, M. E. Sunday, L. G. Que, and M. Kraft. “Increased Tissue Eosinophilia In Obese Asthma May Be Due To Decreased Surfactant Protein-A Levels.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.

Scholars@Duke

Que, L. G., M. Kraft, N. Lugogo, R. Katial, S. A. Shoemaker, and J. M. Troha. “A Novel Therapeutic Target In Asthma: Translational Evidence For Inhibition Of S-Nitrosoglutathione Reductase.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.

Scholars@Duke

Schmalbeck, R., L. Faulk, S. Alaimo, K. Gronbjerg, J. Colombo, D. Mason, T. Dearing, et al. “Ask the Experts.” Wallethub, 2015.

Scholars@Duke

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