Loretta Georgina Que, MD

Professor of Medicine
Campus mail 279 Msrb1, Durham, NC 27710
Phone (919) 681-8551
Email address loretta.que@duke.edu

My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.

Key words: nitrosative defense, lung injury, nitric oxide

Education and Training

  • Pulmonary Fellow, Medicine, Duke University, 1993 - 1996
  • Clinical Instructor, Medicine, Yale University, 1992 - 1993
  • Medical Resident, Medicine, Yale University, 1989 - 1992
  • M.D., The University of Chicago, 1989

Grants

Publications

Yohannes, A. M., M. Eakin, J. T. Holbrook, E. M. Sugar, R. Henderson, A. M. Baker, D. A. Kaminsky, et al. “Chronic Obstructive Pulmonary Disease Related with Increased Risk of Mild Cognitive Impairment.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.

Scholars@Duke

Pederson, W., M. Prasetyo, J. M. Cyphert, R. M. Tighe, L. G. Que, and J. G. Ledford. “Genetic Variation in Surfactant Protein-A2 Differentially Mediates Responses to Ozone.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.

Scholars@Duke

Winnica, D. E., C. Corey, L. G. Que, F. Holguin, and S. Shiva. “Platelet and Airway Epithelium Bioenergetics Are Different in Obese Versus Lean Asthmatics.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.

Scholars@Duke

Wu, Jinhong, Jialong Yang, Kai Yang, Hongxia Wang, Balachandra Gorentla, Jinwook Shin, Yurong Qiu, et al. “iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions.” J Clin Invest, November 1, 2017. https://doi.org/10.1172/JCI98066.

PMID
29091076
Full Text

Suwanpradid, Jutamas, Michael Shih, Lauren Pontius, Bin Yang, Anastasiya Birukova, Emma Guttman-Yassky, David L. Corcoran, Loretta G. Que, Robert M. Tighe, and Amanda S. MacLeod. “Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity.” J Immunol, September 1, 2017. https://doi.org/10.4049/jimmunol.1700739.

PMID
28747341
Full Text

Foster, Matthew W., Zhonghui Yang, David M. Gooden, J Will Thompson, Carol H. Ball, Meredith E. Turner, Yongyong Hou, Jingbo Pi, M Arthur Moseley, and Loretta G. Que. “Correction to "Proteomic Characterization of the Cellular Response to Nitrosative Stress Mediated by S-Nitrosoglutathione Reductase Inhibition".” J Proteome Res 16, no. 7 (July 7, 2017): 2661. https://doi.org/10.1021/acs.jproteome.7b00368.

PMID
28627176
Full Text

Durack, Juliana, Susan V. Lynch, Snehal Nariya, Nirav R. Bhakta, Avraham Beigelman, Mario Castro, Anne-Marie Dyer, et al. “Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment.” J Allergy Clin Immunol 140, no. 1 (July 2017): 63–75. https://doi.org/10.1016/j.jaci.2016.08.055.

PMID
27838347
Full Text

Winnica, D., L. G. Que, C. Baffi, H. Grasemann, K. Fiedler, Z. Yang, E. Etling, et al. “l-citrulline prevents asymmetric dimethylarginine-mediated reductions in nitric oxide and nitrosative stress in primary human airway epithelial cells.” Clin Exp Allergy 47, no. 2 (February 2017): 190–99. https://doi.org/10.1111/cea.12802.

PMID
27562295
Full Text

Giovacchini, Coral X., Lauren Pacek, F Joseph McClernon, and Loretta G. Que. “Use and Perceived Risk of Electronic Cigarettes Among North Carolina Middle and High School Students.” In N C Med J, 78:7–13, 2017. https://doi.org/10.18043/ncm.78.1.7.

PMID
28115555
Full Text

He, Mu, Bastiaan Driehuys, Loretta G. Que, and Yuh-Chin T. Huang. “Using Hyperpolarized 129Xe MRI to Quantify the Pulmonary Ventilation Distribution.” Acad Radiol 23, no. 12 (December 2016): 1521–31. https://doi.org/10.1016/j.acra.2016.07.014.

PMID
27617823
Full Text

Pages