Loretta Georgina Que, MD

Professor of Medicine
Campus mail 279 Msrb1, Durham, NC 27710
Phone (919) 681-8551
Email address loretta.que@duke.edu

My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.

Key words: nitrosative defense, lung injury, nitric oxide

Education and Training

  • Pulmonary Fellow, Medicine, Duke University, 1993 - 1996
  • Clinical Instructor, Medicine, Yale University, 1992 - 1993
  • Medical Resident, Medicine, Yale University, 1989 - 1992
  • M.D., The University of Chicago, 1989

Publications

Baffi, Cynthia W., Lisa Wood, Daniel Winnica, Patrick J. Strollo, Mark T. Gladwin, Loretta G. Que, and Fernando Holguin. “Metabolic Syndrome and the Lung.” Chest 149, no. 6 (June 2016): 1525–34. https://doi.org/10.1016/j.chest.2015.12.034.

PMID
26836925
Full Text

Ledford, Julie G., Kenneth J. Addison, Dave Francisco, Matthew W. Foster, Dennis R. Voelker, Loretta G. Que, and Monica Kraft. “Genetic Variation in Surfactant Protein-A2 Results in Altered Regulation of Eosinophil Activities and Enhanced Eosinophilia in Patients with Asthma.” Ann Am Thorac Soc 13 Suppl 1 (March 2016): S101. https://doi.org/10.1513/AnnalsATS.201508-520MG.

PMID
27027938
Full Text

He, M., S. H. Robertson, J. M. Wang, L. G. Que, K. Mahmood, B. Driehuys, and Y. -. C. Huang. “Characterizing The Ventilation Distribution In Healthy Normal Subjects To Establish Robust Quantitative Analysis Of 129xe Mri.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.

Scholars@Duke

Yang, Z., Y. Bochkov, D. R. Voelker, M. W. Foster, and L. G. Que. “A Gsnor Inhibitor Blocks Hrv Infection Of Primary Human Airway Epithelial Cells.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.

Scholars@Duke

Winnica, D. E., H. Grasemann, L. G. Que, B. Freeman, K. Wasil, S. E. Wenzel, and F. Holguin. “L-Citrulline Prevents Asymmetric Di-Methyl Arginine Uncoupling Of Nitric Oxide Synthase In Primary Human Airway Epithelial Cells.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.

Scholars@Duke

Huang, Y. -. C., and L. G. Que. “Clinical Significance Of Isolated Decrease In Single Breath Lung Volume-Total Lung Capacity Ratio (va/tlc).” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.

Scholars@Duke

Ingram, Jennifer L., David Slade, Tony D. Church, Dave Francisco, Karissa Heck, R Wesley Sigmon, Michael Ghio, et al. “Role of Matrix Metalloproteinases-1 and -2 in Interleukin-13-Suppressed Elastin in Airway Fibroblasts in Asthma.” Am J Respir Cell Mol Biol 54, no. 1 (January 2016): 41–50. https://doi.org/10.1165/rcmb.2014-0290OC.

PMID
26074138
Full Text

Yu, Yen-Rei A., Emily G. O’Koren, Danielle F. Hotten, Matthew J. Kan, David Kopin, Erik R. Nelson, Loretta Que, and Michael D. Gunn. “A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues.” Plos One 11, no. 3 (2016): e0150606. https://doi.org/10.1371/journal.pone.0150606.

PMID
26938654
Full Text

Lugogo, N. L., J. W. Hollingsworth, D. L. Howell, L. G. Que, D. Francisco, T. D. Church, E. N. Potts-Kant, J. L. Ingram, Y. Wang, and S. H. Jung. “Alveolar Macrophages from Overweight/Obese Subjects with Asthma Demonstrate a Proinflammatory Phenotype (Retraction of vol 186, pg 404, 2012).” American Journal of Respiratory and Critical Care Medicine 192, no. 2 (July 15, 2015): 264–264.

Scholars@Duke

Retraction. S-nitrosoglutathione supplementation to ovalbumin-sensitized and -challenged mice ameliorates methacholine-induced bronchoconstriction.” Am J Physiol Lung Cell Mol Physiol 308, no. 9 (May 1, 2015): L981. https://doi.org/10.1152/ajplung.zh5-6751-retr.2015.

PMID
25934761
Full Text

Pages