Loretta Georgina Que, MD

Professor of Medicine
Campus mail 279 Msrb1, Durham, NC 27710
Phone (919) 681-8551
Email address loretta.que@duke.edu

My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.

Key words: nitrosative defense, lung injury, nitric oxide

Education and Training

  • Pulmonary Fellow, Medicine, Duke University, 1993 - 1996
  • Clinical Instructor, Medicine, Yale University, 1992 - 1993
  • Medical Resident, Medicine, Yale University, 1989 - 1992
  • M.D., The University of Chicago, 1989

Grants

Publications

Wang, Y., D. C. Francisco, N. Lugogo, J. Thomas, D. M. Beaver, J. W. Hollingsworth, W. M. Foster, et al. “Genetic Variation In Surfactant Protein A2 Alters Airway Epithelial Response To Mycoplasma Pneumoniae Infection In Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 189. AMER THORACIC SOC, 2014.

Scholars@Duke

Foster, Matthew W., J Will Thompson, Loretta G. Que, Ivana V. Yang, David A. Schwartz, M Arthur Moseley, and Harvey E. Marshall. “Proteomic analysis of human bronchoalveolar lavage fluid after subsgemental exposure.” J Proteome Res 12, no. 5 (May 3, 2013): 2194–2205. https://doi.org/10.1021/pr400066g.

PMID
23550723
Full Text

Wang, Y., D. Francisco, J. M. Thomas, N. Lugogo, L. G. Que, J. G. Ledford, S. Choudhury, D. Beaver, and M. Kraft. “Surfactant Protein A Inhibits Il-13-Induced Pro-Inflammatory Response In Asthmatic Airway Epithelial Cells.” In American Journal of Respiratory and Critical Care Medicine, Vol. 187. AMER THORACIC SOC, 2013.

Scholars@Duke

Foster, M. W., J. W. Thompson, L. G. Que, I. V. Yang, D. A. Schwartz, M. A. Moseley, and H. E. Marshall. “Proteomic Analysis Of Human Bronchoalveolar Lavage Fluid After Subsegmental Challenge.” American Journal of Respiratory and Critical Care Medicine 187 (2013).

Scholars@Duke

Foster, Matthew W., Zhonghui Yang, David M. Gooden, J Will Thompson, Carol H. Ball, Meredith E. Turner, Yongyong Hou, Jingbo Pi, M Arthur Moseley, and Loretta G. Que. “Proteomic characterization of the cellular response to nitrosative stress mediated by s-nitrosoglutathione reductase inhibition.” J Proteome Res 11, no. 4 (April 6, 2012): 2480–91. https://doi.org/10.1021/pr201180m.

PMID
22390303
Full Text

Wang, Ying, Zhou Zhu, Tony D. Church, Njira L. Lugogo, Loretta G. Que, Dave Francisco, Jennifer L. Ingram, et al. “SHP-1 as a critical regulator of Mycoplasma pneumoniae-induced inflammation in human asthmatic airway epithelial cells.” J Immunol 188, no. 7 (April 1, 2012): 3371–81. https://doi.org/10.4049/jimmunol.1100573.

PMID
22371396
Full Text

Yang, Ivana V., John Tomfohr, Jaspal Singh, Catherine M. Foss, Harvey E. Marshall, Loretta G. Que, Erin McElvania-Tekippe, Sarita Florence, John S. Sundy, and David A. Schwartz. “The clinical and environmental determinants of airway transcriptional profiles in allergic asthma.” Am J Respir Crit Care Med 185, no. 6 (March 15, 2012): 620–27. https://doi.org/10.1164/rccm.201108-1503OC.

PMID
22246175
Full Text

Hsia, Bethany J., Amy M. Pastva, Charles D. Giamberardino, Erin N. Potts-Kant, W Michael Foster, Loretta G. Que, Soman N. Abraham, Jo Rae Wright, and David W. Zaas. “Increased Nitric Oxide Production Prevents Airway Hyperresponsiveness in Caveolin-1 Deficient Mice Following Endotoxin Exposure.” J Allergy Ther Suppl 1, no. 4 (January 25, 2012). https://doi.org/10.4172/2155-6121.S1-004.

PMID
24273688
Full Text

Que, Loretta G., Jane V. Stiles, John S. Sundy, and W Michael Foster. “Pulmonary function, bronchial reactivity, and epithelial permeability are response phenotypes to ozone and develop differentially in healthy humans.” J Appl Physiol (1985) 111, no. 3 (September 2011): 679–87. https://doi.org/10.1152/japplphysiol.00337.2011.

PMID
21700892
Full Text

Pages