Lori Ann Orlando, MD

Associate Professor of Medicine
Associate Director of Duke Center for Applied Genomics and Precision Medicine
Campus mail 102906, Aesthetic Center 2nd Floor, Durham, NC 27705
Phone (919) 660-6606
Email address orlan002@duke.edu

Dr. Lori A. Orlando, MD MHS is an Associate Professor of Medicine and Director of the Precision Medicine Program in the Center for Applied Genomics and Precision Medicine at Duke University. She attended Tulane Medical Center for both medical school (1994-1998) and Internal Medicine residency (1998-2000). There she finished AOA and received a number of awards for teaching and clinical care from the medical school and the residency programs, including the Musser-Burch-Puschett award in 2000 for academic excellence. After completing her residency, she served as Chief Medical Resident in Internal Medicine (2001) and then completed a Health Services Research Fellowship at Duke University Medical Center (2002-2004). In 2004 she also received her MHS from the Clinical Research Training Program at Duke University and joined the academic faculty at Duke. In 2005 she received the Milton W. Hamolsky Award for Outstanding Junior Faculty by the Society of General Internal Medicine. Her major research interests are decision making and patient preferences, implementation research, risk stratification for targeting preventive health services, and decision modeling. From 2004-2009 she worked with Dr. David Matchar in the Center for Clinical Heath Policy Research (CCHPR), where she specialized in decision modeling, decision making, and technology assessments. In 2009 she began working with Dr. Geoffrey Ginsburg in what is now the Center for Applied Genomics and Precision Medicine (CAGPM) and in 2014 she became the director of the Center’s Precision Medicine Program. Since joining the CAGPM she has been leading the development and implementation of MeTree, a patient-facing family health history based risk assessment and clinical decision support program designed to facilitate the uptake of risk stratified evidence-based guidelines. MeTree was designed to overcome the major barriers to collecting and using high quality family health histories to guide clinical care and has been shown to be highly effective when integrated into primary care practices. This effort started with the Genomic Medicine Model, a multi-institutional project, whose goal was to implement personalized medicine in primary care practices. The success of that project has led to funding as part of NHGRI’s IGNITE (Implementing Genomics in Clinical Practice) network. She is currently testing methods for integrating patient preferences and decision making processes into clinical decision support recommendations for patients and providers to facilitate management of patients’ risk for chronic disease using mHealth and other behavioral interventions.

Education and Training

  • Fellow in General Internal Medicine, Medicine, Duke University, 2002 - 2004
  • Chief Medical Resident, Medicine, Tulane University, 2001 - 2002
  • Medical Resident, Mecicine, Tulane University, 1998 - 2001
  • M.H.S., Duke University, 2004
  • M.D., Tulane University, 1998

Publications

Li, Josephine H., Scott V. Joy, Susanne B. Haga, Lori A. Orlando, William E. Kraus, Geoffrey S. Ginsburg, and Deepak Voora. “Genetically guided statin therapy on statin perceptions, adherence, and cholesterol lowering: a pilot implementation study in primary care patients..” J Pers Med 4, no. 2 (March 27, 2014): 147–62. https://doi.org/10.3390/jpm4020147.

PMID
25563221
Full Text

Orlando, Lori A., R Ryanne Wu, Chris Beadles, Tiffany Himmel, Adam H. Buchanan, Karen P. Powell, Elizabeth R. Hauser, Vincent C. Henrich, and Geoffrey S. Ginsburg. “Implementing family health history risk stratification in primary care: impact of guideline criteria on populations and resource demand..” Am J Med Genet C Semin Med Genet 166C, no. 1 (March 2014): 24–33. https://doi.org/10.1002/ajmg.c.31388.

PMID
24616329
Full Text

Wu, R Ryanne, Tiffany L. Himmel, Adam H. Buchanan, Karen P. Powell, Elizabeth R. Hauser, Geoffrey S. Ginsburg, Vincent C. Henrich, and Lori A. Orlando. “Quality of family history collection with use of a patient facing family history assessment tool..” Bmc Fam Pract 15 (February 13, 2014). https://doi.org/10.1186/1471-2296-15-31.

PMID
24520818
Full Text

Mather, Richard C., Kevin T. Hug, Lori A. Orlando, Tyler Steven Watters, Lane Koenig, Ryan M. Nunley, and Michael P. Bolognesi. “Economic evaluation of access to musculoskeletal care: the case of waiting for total knee arthroplasty..” Bmc Musculoskelet Disord 15 (January 18, 2014). https://doi.org/10.1186/1471-2474-15-22.

PMID
24438051
Full Text

Wu, R. R., T. L. Himmel, A. H. Buchanan, K. P. Powell, E. R. Hauser, G. S. Ginsburg, V. C. Henrich, and L. A. Orlando. “Quality of family history collection with use of a patient facing family history assessment tool.” Bmc Family Practice 15, no. 1 (2014). https://doi.org/10.1186/1471-2296-15-31.

Full Text

Wu, R Ryanne, Lori A. Orlando, Tiffany L. Himmel, Adam H. Buchanan, Karen P. Powell, Elizabeth R. Hauser, Astrid B. Agbaje, Vincent C. Henrich, and Geoffrey S. Ginsburg. “Patient and primary care provider experience using a family health history collection, risk stratification, and clinical decision support tool: a type 2 hybrid controlled implementation-effectiveness trial..” Bmc Fam Pract 14 (August 6, 2013). https://doi.org/10.1186/1471-2296-14-111.

PMID
23915256
Full Text

Vorderstrasse, Allison A., Alex Cho, Corrine I. Voils, Lori A. Orlando, and Geoffrey S. Ginsburg. “Clinical utility of genetic risk testing in primary care: the example of Type 2 diabetes..” Per Med 10, no. 6 (August 2013): 549–63. https://doi.org/10.2217/pme.13.47.

PMID
29776196
Full Text

Powell, Karen P., Carol A. Christianson, Susan E. Hahn, Gaurav Dave, Leslie R. Evans, Susan H. Blanton, Elizabeth Hauser, et al. “Collection of family health history for assessment of chronic disease risk in primary care..” N C Med J 74, no. 4 (July 2013): 279–86.

PMID
24044144
Scholars@Duke

Orlando, Lori A., Adam H. Buchanan, Susan E. Hahn, Carol A. Christianson, Karen P. Powell, Celette Sugg Skinner, Blair Chesnut, et al. “Development and validation of a primary care-based family health history and decision support program (MeTree)..” N C Med J 74, no. 4 (July 2013): 287–96.

PMID
24044145
Scholars@Duke

Pages