Gastroenterology

Manal F. Abdelmalek, MD

Professor of Medicine
Campus mail 03119 Hosp South, Suite 03107, Room 03125, Durham, NC 27710
Phone (919) 684-3262
Email address manal.abdelmalek@duke.edu

My research interests include metabolic liver disease, particularly obesity-related liver disease and its association with complications of the insulin resistance syndrome. I am interested in studying the clinical, environmental, and genetic risk factors for nonalcoholic fatty liver disease, new therapeutic options for treatment, and evaluating the impact of NAFLD from a public health perspective.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Mayo School of Health Sciences, 1995 - 1998
  • Medical Resident, Medicine, Mayo School of Health Sciences, 1992 - 1995
  • M.D., University Missouri Kansas City, 1992

Grants

Publications

Ratziu, Vlad, Arun Sanyal, Stephen A. Harrison, Vincent Wai-Sun Wong, Sven Francque, Zachary Goodman, Guruprasad P. Aithal, et al. “Cenicriviroc Treatment for Adults with Nonalcoholic Steatohepatitis and Fibrosis: Final Analysis of the Phase 2b CENTAUR Study.” In Hepatology, 2020. https://doi.org/10.1002/hep.31108.

PMID
31943293
Full Text

Liu, Xue-Jing, Li Xie, Kuo Du, Chang Liu, Ning-Ping Zhang, Chen-Jian Gu, Ying Wang, et al. “Succinate-GPR-91 receptor signalling is responsible for nonalcoholic steatohepatitis-associated fibrosis: Effects of DHA supplementation.” Liver Int, January 6, 2020. https://doi.org/10.1111/liv.14370.

PMID
31903720
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Satapathy, Sanjaya K., Yu Jiang, Uchenna Agbim, Cen Wu, David E. Bernstein, Lewis W. Teperman, Satish K. Kedia, et al. “Posttransplant Outcome of Lean Compared With Obese Nonalcoholic Steatohepatitis in the United States: The Obesity Paradox.” In Liver Transpl, 26:68–79, 2020. https://doi.org/10.1002/lt.25672.

PMID
31665561
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Siddiqui, Mohammad Shadab, Mark L. Van Natta, Margery A. Connelly, Raj Vuppalanchi, Brent A. Neuschwander-Tetri, James Tonascia, Cynthia Guy, et al. “Impact of obeticholic acid on the lipoprotein profile in patients with non-alcoholic steatohepatitis.” J Hepatol 72, no. 1 (January 2020): 25–33. https://doi.org/10.1016/j.jhep.2019.10.006.

PMID
31634532
Full Text

Du, Kuo, Satish K. Chitneni, Ayako Suzuki, Ying Wang, Ricardo Henao, Jeongeun Hyun, Richard T. Premont, et al. “Increased Glutaminolysis Marks Active Scarring in Nonalcoholic Steatohepatitis Progression.” Cell Mol Gastroenterol Hepatol, December 25, 2019. https://doi.org/10.1016/j.jcmgh.2019.12.006.

PMID
31881361
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Anstee, Quentin M., Brent A. Neuschwander-Tetri, Vincent Wai-Sun Wong, Manal F. Abdelmalek, Zobair M. Younossi, Jiacheng Yuan, Maria Lucia Pecoraro, et al. “Cenicriviroc for the treatment of liver fibrosis in adults with nonalcoholic steatohepatitis: AURORA Phase 3 study design.” Contemp Clin Trials 89 (December 24, 2019): 105922. https://doi.org/10.1016/j.cct.2019.105922.

PMID
31881392
Full Text

Du, Kuo, Seh Hoon Oh, Tianai Sun, Wen-Hsuan Yang, Jen-Tsan Ashley Chi, and Anna Mae Diehl. “Inhibiting xCT/SLC7A11 induces ferroptosis of myofibroblastic hepatic stellate cells and protects against liver fibrosis,” 2019. https://doi.org/10.1101/2019.12.23.886259.

Full Text

Sanyal, Arun, Edgar D. Charles, Brent A. Neuschwander-Tetri, Rohit Loomba, Stephen A. Harrison, Manal F. Abdelmalek, Eric J. Lawitz, et al. “Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial.” Lancet 392, no. 10165 (December 22, 2019): 2705–17. https://doi.org/10.1016/S0140-6736(18)31785-9.

PMID
30554783
Full Text

Garcia-Tsao, Guadalupe, Jaime Bosch, Zeid Kayali, Stephen A. Harrison, Manal F. Abdelmalek, Eric Lawitz, Sanjaya K. Satapathy, et al. “Randomized Placebo-Controlled Trial of Emricasan in Non-alcoholic Steatohepatitis (NASH) Cirrhosis with Severe Portal Hypertension.” J Hepatol, December 20, 2019. https://doi.org/10.1016/j.jhep.2019.12.010.

PMID
31870950
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Younossi, Zobair M., Vlad Ratziu, Rohit Loomba, Mary Rinella, Quentin M. Anstee, Zachary Goodman, Pierre Bedossa, et al. “Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial.” Lancet 394, no. 10215 (December 14, 2019): 2184–96. https://doi.org/10.1016/S0140-6736(19)33041-7.

PMID
31813633
Full Text

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