Manal F. Abdelmalek, MD

Professor of Medicine
Campus mail 03119 Hosp South, Suite 03107, Room 03125, Durham, NC 27710
Phone (919) 684-3262
Email address manal.abdelmalek@duke.edu

My research interests include metabolic liver disease, particularly obesity-related liver disease and its association with complications of the insulin resistance syndrome. I am interested in studying the clinical, environmental, and genetic risk factors for nonalcoholic fatty liver disease, new therapeutic options for treatment, and evaluating the impact of NAFLD from a public health perspective.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Mayo School of Health Sciences, 1995 - 1998
  • Medical Resident, Medicine, Mayo School of Health Sciences, 1992 - 1995
  • M.D., University Missouri Kansas City, 1992

Publications

Siddiqui, MS, Harrison, SA, Abdelmalek, MF, Anstee, QM, Bedossa, P, Castera, L, Dimick-Santos, L, Friedman, SL, Greene, K, Kleiner, DE, Megnien, S, Neuschwander-Tetri, BA, Ratziu, V, Schabel, E, Miller, V, Sanyal, AJ, and Liver Forum Case Definitions Working Group, . "Case definitions for inclusion and analysis of endpoints in clinical trials for nonalcoholic steatohepatitis through the lens of regulatory science." Hepatology (Baltimore, Md.) 67, no. 5 (May 2018): 2001-2012.

PMID
29059456
Full Text

Jensen, T, Abdelmalek, MF, Sullivan, S, Nadeau, KJ, Green, M, Roncal, C, Nakagawa, T, Kuwabara, M, Sato, Y, Kang, D-H, Tolan, DR, Sanchez-Lozada, LG, Rosen, HR, Lanaspa, MA, Diehl, AM, and Johnson, RJ. "Fructose and sugar: A major mediator of non-alcoholic fatty liver disease." Journal of Hepatology 68, no. 5 (May 2018): 1063-1075. (Review)

PMID
29408694
Full Text

Friedman, SL, Ratziu, V, Harrison, SA, Abdelmalek, MF, Aithal, GP, Caballeria, J, Francque, S, Farrell, G, Kowdley, KV, Craxi, A, Simon, K, Fischer, L, Melchor-Khan, L, Vest, J, Wiens, BL, Vig, P, Seyedkazemi, S, Goodman, Z, Wong, VW-S, Loomba, R, Tacke, F, Sanyal, A, and Lefebvre, E. "A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis." Hepatology (Baltimore, Md.) 67, no. 5 (May 2018): 1754-1767.

PMID
28833331
Full Text

Harrison, SA, Rinella, ME, Abdelmalek, MF, Trotter, JF, Paredes, AH, Arnold, HL, Kugelmas, M, Bashir, MR, Jaros, MJ, Ling, L, Rossi, SJ, DePaoli, AM, and Loomba, R. "NGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial." Lancet (London, England) 391, no. 10126 (March 5, 2018): 1174-1185.

PMID
29519502
Full Text

Vuppalanchi, R, Siddiqui, MS, Van Natta, ML, Hallinan, E, Brandman, D, Kowdley, K, Neuschwander-Tetri, BA, Loomba, R, Dasarathy, S, Abdelmalek, M, Doo, E, Tonascia, JA, Kleiner, DE, Sanyal, AJ, Chalasani, N, and NASH Clinical Research Network, . "Performance characteristics of vibration-controlled transient elastography for evaluation of nonalcoholic fatty liver disease." Hepatology (Baltimore, Md.) 67, no. 1 (January 2018): 134-144.

PMID
28859228
Full Text

Younossi, ZM, Loomba, R, Rinella, ME, Bugianesi, E, Marchesini, G, Neuschwander-Tetri, BA, Serfaty, L, Negro, F, Caldwell, SH, Ratziu, V, Corey, KE, Friedman, SL, Abdelmalek, MF, Harrison, SA, Sanyal, AJ, Lavine, JE, Mathurin, P, Charlton, MR, Chalasani, NP, Anstee, QM, Kowdley, KV, George, J, Goodman, ZD, and Lindor, K. "Current and Future Therapeutic Regimens for Non-alcoholic Fatty Liver Disease (NAFLD) and Non-alcoholic Steatohepatitis (NASH)." Hepatology (Baltimore, Md.) (December 9, 2017). (Review)

PMID
29222911
Full Text

Younossi, ZM, Loomba, R, Anstee, QM, Rinella, ME, Bugianesi, E, Marchesini, G, Neuschwander-Tetri, BA, Serfaty, L, Negro, F, Caldwell, SH, Ratziu, V, Corey, KE, Friedman, SL, Abdelmalek, MF, Harrison, SA, Sanyal, AJ, Lavine, JE, Mathurin, P, Charlton, MR, Goodman, ZD, Chalasani, NP, Kowdley, KV, George, J, and Lindor, K. "Diagnostic Modalities for Non-alcoholic Fatty Liver Disease (NAFLD), Non-alcoholic Steatohepatitis (NASH) and Associated Fibrosis." Hepatology (Baltimore, Md.) (December 9, 2017). (Review)

PMID
29222917
Full Text

Guy, CD, Suzuki, A, Swiderska-Syn, M, Abdelmalek, MF, and Diehl, AM. "Hepatocellular injury and senescence in NASH are linked to Hedgehog and Hippo pathway activity and accumulation of hepatic progenitor cells." October 2017.

Scholars@Duke

Moylan, CA, Mavis, AM, Bashir, MR, Malik, D, Bozdogan, E, Buie, S, Hoyo, C, Diehl, AM, Murphy, SK, and Abdelmalek, MF. "Visceral and subcutaneous adipose tissue measurements associate with increased metabolic risk for NAFLD in pre-pubertal obese children." October 2017.

Scholars@Duke

Abdelmalek, MF, Henao, R, Wang, Y, Guy, CD, Bashir, MR, Johnson, R, Diehl, AM, and Soher, B. "Fructose-Related Hepatic ATP Depletion Induces Hyperuricemia in Healthy Volunteers and Patients with Biopsy-Proven Nonalcoholic Fatty Liver Disease." October 2017.

Scholars@Duke

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