Gastroenterology

Manal F. Abdelmalek, MD

Professor of Medicine
Campus mail 03119 Hosp South, Suite 03107, Room 03125, Durham, NC 27710
Phone (919) 684-3262
Email address manal.abdelmalek@duke.edu

My research interests include metabolic liver disease, particularly obesity-related liver disease and its association with complications of the insulin resistance syndrome. I am interested in studying the clinical, environmental, and genetic risk factors for nonalcoholic fatty liver disease, new therapeutic options for treatment, and evaluating the impact of NAFLD from a public health perspective.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Mayo School of Health Sciences, 1995 - 1998
  • Medical Resident, Medicine, Mayo School of Health Sciences, 1992 - 1995
  • M.D., University Missouri Kansas City, 1992

Grants

Publications

Sanyal, Arun, Edgar D. Charles, Brent A. Neuschwander-Tetri, Rohit Loomba, Stephen A. Harrison, Manal F. Abdelmalek, Eric J. Lawitz, et al. “Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial..” Lancet 392, no. 10165 (December 22, 2019): 2705–17. https://doi.org/10.1016/S0140-6736(18)31785-9.

PMID
30554783
Full Text

Rana, R., A. M. Shearer, E. K. Fletcher, N. Nguyen, S. Guha, D. H. Cox, M. Abdelmalek, et al. “PAR2 controls cholesterol homeostasis and lipid metabolism in nonalcoholic fatty liver disease.” Molecular Metabolism 29 (November 1, 2019): 99–113. https://doi.org/10.1016/j.molmet.2019.08.019.

Full Text

Lonardo, Amedeo, Fabio Nascimbeni, Stefano Ballestri, DeLisa Fairweather, Sanda Win, Tin A. Than, Manal F. Abdelmalek, and Ayako Suzuki. “Sex Differences in Nonalcoholic Fatty Liver Disease: State of the Art and Identification of Research Gaps..” Hepatology 70, no. 4 (October 2019): 1457–69. https://doi.org/10.1002/hep.30626.

PMID
30924946
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Gawrieh, Samer, Laura A. Wilson, Oscar W. Cummings, Jeanne M. Clark, Rohit Loomba, Bilal Hameed, Manal F. Abdelmalek, et al. “Histologic Findings of Advanced Fibrosis and Cirrhosis in Patients With Nonalcoholic Fatty Liver Disease Who Have Normal Aminotransferase Levels..” Am J Gastroenterol 114, no. 10 (October 2019): 1626–35. https://doi.org/10.14309/ajg.0000000000000388.

PMID
31517638
Full Text

Win, Sanda, Robert Wm Min, Christopher Q. Chen, Jun Zhang, Yibu Chen, Meng Li, Ayako Suzuki, et al. “Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury..” J Clin Invest, September 5, 2019. https://doi.org/10.1172/JCI128289.

PMID
31487267
Full Text

Loomba, Rohit, Anjali Jain, Anna Mae Diehl, Cynthia D. Guy, Dana Portenier, Ranjan Sudan, Seema Singh, et al. “Validation of Serum Test for Advanced Liver Fibrosis in Patients With Nonalcoholic Steatohepatitis..” Clin Gastroenterol Hepatol 17, no. 9 (August 2019): 1867-1876.e3. https://doi.org/10.1016/j.cgh.2018.11.004.

PMID
30448594
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Siddiqui, Mohammad Shadab, Goro Yamada, Raj Vuppalanchi, Mark Van Natta, Rohit Loomba, Cynthia Guy, Danielle Brandman, et al. “Diagnostic Accuracy of Noninvasive Fibrosis Models to Detect Change in Fibrosis Stage..” Clin Gastroenterol Hepatol 17, no. 9 (August 2019): 1877-1885.e5. https://doi.org/10.1016/j.cgh.2018.12.031.

PMID
30616027
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Samji, Naga Swetha, Rajanshu Verma, Krishna Chaitanya Keri, Ashwani K. Singal, Aijaz Ahmed, Mary Rinella, David Bernstein, Manal F. Abdelmalek, and Sanjaya K. Satapathy. “Liver Transplantation for Nonalcoholic Steatohepatitis: Pathophysiology of Recurrence and Clinical Challenges..” Dig Dis Sci, July 16, 2019. https://doi.org/10.1007/s10620-019-05716-1.

PMID
31312990
Full Text

Wegermann, Kara, Catherine Howe, Ricardo Henao, Ying Wang, Anna Mae Diehl, Manal F. Abdelmalek, and Cynthia A. Moylan. “BRANCHED CHAIN AMINO ACID AND BILE ACID METABOLITES ASSOCIATE WITH FUTURE CLINICAL DECOMPENSATION IN NONALCOHOLIC FATTY LIVER DISEASE.” In Gastroenterology, 156:S1223–S1223. W B SAUNDERS CO-ELSEVIER INC, 2019.

Scholars@Duke

Chalasani, Naga, Manal F. Abdelmalek, Rohit Loomba, Kris V. Kowdley, Arthur J. McCullough, Srinivasan Dasarathy, Brent A. Neuschwander-Tetri, et al. “Relationship between three commonly used non-invasive fibrosis biomarkers and improvement in fibrosis stage in patients with non-alcoholic steatohepatitis..” Liver Int 39, no. 5 (May 2019): 924–32. https://doi.org/10.1111/liv.13974.

PMID
30253043
Full Text

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