Gastroenterology

Manal F. Abdelmalek, MD

Professor of Medicine
Campus mail 03119 Hosp South, Suite 03107, Room 03125, Durham, NC 27710
Phone (919) 684-3262
Email address manal.abdelmalek@duke.edu

My research interests include metabolic liver disease, particularly obesity-related liver disease and its association with complications of the insulin resistance syndrome. I am interested in studying the clinical, environmental, and genetic risk factors for nonalcoholic fatty liver disease, new therapeutic options for treatment, and evaluating the impact of NAFLD from a public health perspective.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Mayo School of Health Sciences, 1995 - 1998
  • Medical Resident, Medicine, Mayo School of Health Sciences, 1992 - 1995
  • M.D., University Missouri Kansas City, 1992

Grants

Publications

Sanyal, Arun, Edgar D. Charles, Brent A. Neuschwander-Tetri, Rohit Loomba, Stephen A. Harrison, Manal F. Abdelmalek, Eric J. Lawitz, et al. “Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial..” Lancet (London, England) 392, no. 10165 (December 2019): 2705–17. https://doi.org/10.1016/s0140-6736(18)31785-9.

PMID
30554783
Full Text

Chalasani, Naga, Manal F. Abdelmalek, Rohit Loomba, Kris V. Kowdley, Arthur J. McCullough, Srinivasan Dasarathy, Brent A. Neuschwander-Tetri, et al. “Relationship between three commonly used non-invasive fibrosis biomarkers and improvement in fibrosis stage in patients with non-alcoholic steatohepatitis..” Liver Int 39, no. 5 (May 2019): 924–32. https://doi.org/10.1111/liv.13974.

PMID
30253043
Full Text

Corey, Kathleen E., Laura A. Wilson, Akif Altinbas, Katherine P. Yates, David E. Kleiner, Raymond T. Chung, Ronald M. Krauss, Naga Chalasani, and Naga NASH Clinical Research Network. “Relationship between resolution of non-alcoholic steatohepatitis and changes in lipoprotein sub-fractions: a post-hoc analysis of the PIVENS trial..” Aliment Pharmacol Ther 49, no. 9 (May 2019): 1205–13. https://doi.org/10.1111/apt.15216.

PMID
30854694
Full Text

Sanyal, Arun J., Stephen A. Harrison, Vlad Ratziu, Manal F. Abdelmalek, Anna Mae Diehl, Stephen Caldwell, Mitchell L. Shiffman, et al. “The Natural History of Advanced Fibrosis due to Nonalcoholic Steatohepatitis: Data from the Simtuzumab Trials..” Hepatology, April 16, 2019. https://doi.org/10.1002/hep.30664.

PMID
30993748
Full Text

Rinella, Mary E., James F. Trotter, Manal F. Abdelmalek, Angelo H. Paredes, Margery A. Connelly, Mark J. Jaros, Lei Ling, Stephen J. Rossi, Alex M. DePaoli, and Stephen A. Harrison. “Rosuvastatin improves the FGF19 analogue NGM282-associated lipid changes in patients with non-alcoholic steatohepatitis..” Journal of Hepatology 70, no. 4 (April 2019): 735–44. https://doi.org/10.1016/j.jhep.2018.11.032.

PMID
30529590
Full Text

Lonardo, Amedeo, Fabio Nascimbeni, Stefano Ballestri, DeLisa Fairweather, Sanda Win, Tin A. Than, Manal F. Abdelmalek, and Ayako Suzuki. “Sex Differences in NAFLD: State of the Art and Identification of Research Gaps..” Hepatology (Baltimore, Md.), March 29, 2019. https://doi.org/10.1002/hep.30626.

PMID
30924946
Full Text

Loomba, Rohit, Arun J. Sanyal, Kris V. Kowdley, Norah Terrault, Naga P. Chalasani, Manal F. Abdelmalek, Arthur J. McCullough, et al. “Factors Associated With Histologic Response in Adult Patients With Nonalcoholic Steatohepatitis..” Gastroenterology 156, no. 1 (January 2019): 88-95.e5. https://doi.org/10.1053/j.gastro.2018.09.021.

PMID
30222962
Full Text

Jayakumar, Saumya, Michael S. Middleton, Eric J. Lawitz, Parvez S. Mantry, Stephen H. Caldwell, Hays Arnold, Anna Mae Diehl, et al. “Longitudinal correlations between MRE, MRI-PDFF, and liver histology in patients with non-alcoholic steatohepatitis: Analysis of data from a phase II trial of selonsertib..” Journal of Hepatology 70, no. 1 (January 2019): 133–41. https://doi.org/10.1016/j.jhep.2018.09.024.

PMID
30291868
Full Text

Siddiqui, Mohammad S., Raj Vuppalanchi, Mark L. Van Natta, Erin Hallinan, Kris V. Kowdley, Manal Abdelmalek, Brent A. Neuschwander-Tetri, et al. “Vibration-Controlled Transient Elastography to Assess Fibrosis and Steatosis in Patients With Nonalcoholic Fatty Liver Disease..” Clinical Gastroenterology and Hepatology : The Official Clinical Practice Journal of the American Gastroenterological Association 17, no. 1 (January 2019): 156-163.e2. https://doi.org/10.1016/j.cgh.2018.04.043.

PMID
29705261
Full Text

Paredes, Angelo H., James F. Trotter, Mustafa R. Bashir, Guy W. Neff, Manal F. Abdelmalek, Grisell Ortiz-Lasanta, Mark Jaros, et al. “NGM282 Maintains a Durable Off-Treatment Response on Hepatic Steatosis, Inflammation and Fibrogenesis in Patients with Biopsy-Confirmed Nonalcoholic Steatohepatitis: Results of a Multi-Center Phase 2 Dose-Finding Study.” In Hepatology, 68:1460A-1461A. WILEY, 2018.

Scholars@Duke

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