Gastroenterology

Manal F. Abdelmalek, MD

Professor of Medicine
Campus mail 03119 Hosp South, Suite 03107, Room 03125, Durham, NC 27710
Phone (919) 684-3262
Email address manal.abdelmalek@duke.edu

My research interests include metabolic liver disease, particularly obesity-related liver disease and its association with complications of the insulin resistance syndrome. I am interested in studying the clinical, environmental, and genetic risk factors for nonalcoholic fatty liver disease, new therapeutic options for treatment, and evaluating the impact of NAFLD from a public health perspective.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Mayo School of Health Sciences, 1995 - 1998
  • Medical Resident, Medicine, Mayo School of Health Sciences, 1992 - 1995
  • M.D., University Missouri Kansas City, 1992

Grants

Publications

Sanyal, A, Charles, ED, Neuschwander-Tetri, BA, Loomba, R, Harrison, SA, Abdelmalek, MF, Lawitz, EJ, Halegoua-DeMarzio, D, Kundu, S, Noviello, S, Luo, Y, and Christian, R. "Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial.(Accepted)" Lancet (London, England) 392, no. 10165 (December 2019): 2705-2717.

PMID
30554783
Full Text

Loomba, R, Sanyal, AJ, Kowdley, KV, Terrault, N, Chalasani, NP, Abdelmalek, MF, McCullough, AJ, Shringarpure, R, Ferguson, B, Lee, L, Chen, J, Liberman, A, Shapiro, D, and Neuschwander-Tetri, BA. "Factors Associated With Histologic Response in Adult Patients With Nonalcoholic Steatohepatitis." Gastroenterology 156, no. 1 (January 2019): 88-95.e5.

PMID
30222962
Full Text

Jayakumar, S, Middleton, MS, Lawitz, EJ, Mantry, PS, Caldwell, SH, Arnold, H, Mae Diehl, A, Ghalib, R, Elkhashab, M, Abdelmalek, MF, Kowdley, KV, Stephen Djedjos, C, Xu, R, Han, L, Mani Subramanian, G, Myers, RP, Goodman, ZD, Afdhal, NH, Charlton, MR, Sirlin, CB, and Loomba, R. "Longitudinal correlations between MRE, MRI-PDFF, and liver histology in patients with non-alcoholic steatohepatitis: Analysis of data from a phase II trial of selonsertib." Journal of Hepatology 70, no. 1 (January 2019): 133-141.

PMID
30291868
Full Text

Siddiqui, MS, Vuppalanchi, R, Van Natta, ML, Hallinan, E, Kowdley, KV, Abdelmalek, M, Neuschwander-Tetri, BA, Loomba, R, Dasarathy, S, Brandman, D, Doo, E, Tonascia, JA, Kleiner, DE, Chalasani, N, Sanyal, AJ, and NASH Clinical Research Network, . "Vibration-Controlled Transient Elastography to Assess Fibrosis and Steatosis in Patients With Nonalcoholic Fatty Liver Disease." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association 17, no. 1 (January 2019): 156-163.e2.

PMID
29705261
Full Text

Rinella, ME, Trotter, JF, Abdelmalek, MF, Paredes, AH, Connelly, MA, Jaros, MJ, Ling, L, Rossi, SJ, DePaoli, AM, and Harrison, SA. "Rosuvastatin improves the FGF19 analogue NGM282-associated lipid changes in patients with non-alcoholic steatohepatitis." Journal of Hepatology (December 8, 2018).

PMID
30529590
Full Text

Younossi, Z, Stepanova, M, Sanyal, AJ, Harrison, SA, Ratziu, V, Abdelmalek, MF, Diehl, AM, Caldwell, S, Shiffman, ML, Schall, RA, McColgan, B, Subramanian, GM, Myers, RP, Muir, A, Afdhal, NH, Bosch, J, and Goodman, Z. "The conundrum of cryptogenic cirrhosis: Adverse outcomes without treatment options." Journal of Hepatology 69, no. 6 (December 2018): 1365-1370.

PMID
30144554
Full Text

Loomba, R, Jain, A, Diehl, AM, Guy, CD, Portenier, D, Sudan, R, Singh, S, Faulkner, C, Richards, L, Hester, KD, Okada, L, Li, X-J, Mimms, L, and Abdelmalek, MF. "Validation of Serum Test for Advanced Liver Fibrosis in Patients With Nonalcoholic Steatohepatitis." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association (November 15, 2018).

PMID
30448594
Full Text

Wildman-Tobriner, B, Middleton, MM, Moylan, CA, Rossi, S, Flores, O, Chang, ZA, Abdelmalek, MF, Sirlin, CB, and Bashir, MR. "Association Between Magnetic Resonance Imaging-Proton Density Fat Fraction and Liver Histology Features in Patients With Nonalcoholic Fatty Liver Disease or Nonalcoholic Steatohepatitis." Gastroenterology 155, no. 5 (November 2018): 1428-1435.e2.

PMID
30031769
Full Text

Glass, O, Henao, R, Patel, K, Guy, CD, Gruss, HJ, Syn, W-K, Moylan, CA, Streilein, R, Hall, R, Mae Diehl, A, and Abdelmalek, MF. "Serum Interleukin-8, Osteopontin, and Monocyte Chemoattractant Protein 1 Are Associated With Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease." Hepatology Communications 2, no. 11 (November 2018): 1344-1355.

PMID
30411081
Full Text

Abdelmalek, MF, Lanthier, N, Chojkier, M, Kluwe, J, Fowell, AJ, Yuan, J, Nicandro, JP, Seyedkazemi, S, Fischer, L, Goodman, ZD, and Harrison, SA. "Cenicriviroc Treatment over 2 Years Results in Clinically Meaningful and Sustained Improvement in Fibrosis in Adults with Nonalcoholic Steatohepatitis and Severe Liver Fibrosis." Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting. San Francisco, CA. November 9, 2018 - November 13, 2018.: WILEY, October 1, 2018.

Scholars@Duke

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