Gastroenterology

Manal F. Abdelmalek, MD

Professor of Medicine
Campus mail 03119 Hosp South, Suite 03107, Room 03125, Durham, NC 27710
Phone (919) 684-3262
Email address manal.abdelmalek@duke.edu

My research interests include metabolic liver disease, particularly obesity-related liver disease and its association with complications of the insulin resistance syndrome. I am interested in studying the clinical, environmental, and genetic risk factors for nonalcoholic fatty liver disease, new therapeutic options for treatment, and evaluating the impact of NAFLD from a public health perspective.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Mayo School of Health Sciences, 1995 - 1998
  • Medical Resident, Medicine, Mayo School of Health Sciences, 1992 - 1995
  • M.D., University Missouri Kansas City, 1992

Grants

Weight
-20

Publications

Sanyal, Arun, Edgar D. Charles, Brent A. Neuschwander-Tetri, Rohit Loomba, Stephen A. Harrison, Manal F. Abdelmalek, Eric J. Lawitz, et al. “Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial..” Lancet 392, no. 10165 (December 22, 2019): 2705–17. https://doi.org/10.1016/S0140-6736(18)31785-9.

PMID
30554783
Full Text

Win, Sanda, Robert Wm Min, Christopher Q. Chen, Jun Zhang, Yibu Chen, Meng Li, Ayako Suzuki, et al. “Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury..” J Clin Invest 129, no. 12 (December 2, 2019): 5278–93. https://doi.org/10.1172/JCI128289.

PMID
31487267
Full Text

Sanyal, Arun J., Stephen A. Harrison, Vlad Ratziu, Manal F. Abdelmalek, Anna Mae Diehl, Stephen Caldwell, Mitchell L. Shiffman, et al. “The Natural History of Advanced Fibrosis Due to Nonalcoholic Steatohepatitis: Data From the Simtuzumab Trials..” Hepatology 70, no. 6 (December 2019): 1913–27. https://doi.org/10.1002/hep.30664.

PMID
30993748
Full Text

Samji, Naga Swetha, Rajanshu Verma, Krishna Chaitanya Keri, Ashwani K. Singal, Aijaz Ahmed, Mary Rinella, David Bernstein, Manal F. Abdelmalek, and Sanjaya K. Satapathy. “Liver Transplantation for Nonalcoholic Steatohepatitis: Pathophysiology of Recurrence and Clinical Challenges..” Dig Dis Sci 64, no. 12 (December 2019): 3413–30. https://doi.org/10.1007/s10620-019-05716-1.

PMID
31312990
Full Text

Rana, Rajashree, Andrew M. Shearer, Elizabeth K. Fletcher, Nga Nguyen, Srijoy Guha, Daniel H. Cox, Manal Abdelmalek, et al. “PAR2 controls cholesterol homeostasis and lipid metabolism in nonalcoholic fatty liver disease..” Mol Metab 29 (November 2019): 99–113. https://doi.org/10.1016/j.molmet.2019.08.019.

PMID
31668396
Full Text

Satapathy, Sanjaya K., Yu Jiang, Uchenna Agbim, Cen Wu, David E. Bernstein, Lewis W. Teperman, Satish K. Kedia, et al. “Post-transplant Outcome of Lean Compared to Obese Nonalcoholic Steatohepatitis in the United States: The Obesity Paradox..” In Liver Transpl, 2019. https://doi.org/10.1002/lt.25672.

PMID
31665561
Full Text

Wegermann, Kara, Catherine Howe, Ricardo Henao, Ying Wang, Anna Mae Diehl, Manal F. Abdelmalek, and Cynthia A. Moylan. “PRIMARY BILE ACID AND BRANCHED CHAIN AMINO ACID METABOLITES ASSOCIATE WITH DIASTOLIC HEART FAILURE IN NON-ALCOHOLIC FATTY LIVER DISEASE.” In Hepatology, 70:1039A-1039A. WILEY, 2019.

Scholars@Duke

Glass, Oliver, Ying Wang, Daniel Liu, Cynthia D. Guy, Anna Mae Diehl, and Manal F. Abdelmalek. “EXERCISE BEHAVIOR IN PATIENTS WITH BIOPSY-PROVEN NON-ALCOHOLIC FATTY LIVER DISEASE.” In Hepatology, 70:748A-748A. WILEY, 2019.

Scholars@Duke

Moylan, Cynthia A., Kuo Du, Jeongeun Hyun, Kara Wegermann, Manal F. Abdelmalek, Anna Mae Diehl, and Cynthia D. Guy. “EXPRESSION OF BRANCHED CHAIN AMINO ACID TRANSAMINASE 1 (BCAT1) IS INCREASED IN NAFLD FIBROSIS AND CIRRHOSIS AND HEPATOCELLULAR CARCINOMA.” In Hepatology, 70:1335A-1336A. WILEY, 2019.

Scholars@Duke

Harrison, Stephen A., Eric J. Lawitz, Vincent Wai-Sun Wong, Quentin M. Anstee, Michael H. Trauner, Manuel Romero-Gomez, Bal Bhandari, et al. “CURRENTLY AVAILABLE NONINVASIVE TESTS ACCURATELY STAGE FIBROSIS IN PATIENTS WITH NONALCOHOLIC STEATOHEPATITIS (NASH).” In Hepatology, 70:1349A-1350A. WILEY, 2019.

Scholars@Duke

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