Manal F. Abdelmalek, MD

Professor of Medicine
Campus mail 03119 Hosp South, Suite 03107, Room 03125, Durham, NC 27710
Phone (919) 684-3262
Email address manal.abdelmalek@duke.edu

My research interests include metabolic liver disease, particularly obesity-related liver disease and its association with complications of the insulin resistance syndrome. I am interested in studying the clinical, environmental, and genetic risk factors for nonalcoholic fatty liver disease, new therapeutic options for treatment, and evaluating the impact of NAFLD from a public health perspective.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Mayo School of Health Sciences, 1995 - 1998
  • Medical Resident, Medicine, Mayo School of Health Sciences, 1992 - 1995
  • M.D., University of Missouri Kansas City, School of Medicine, 1992

Grants

Publications

Bosch, Jaime, Chuhan Chung, Oscar M. Carrasco-Zevallos, Stephen A. Harrison, Manal F. Abdelmalek, Mitchell L. Shiffman, Don C. Rockey, et al. “A Machine Learning Approach to Liver Histological Evaluation Predicts Clinically Significant Portal Hypertension in NASH Cirrhosis.” Hepatology 74, no. 6 (December 2021): 3146–60. https://doi.org/10.1002/hep.32087.

PMID
34333790
Full Text

Abdelmalek, Manal F., Arun J. Sanyal, Atsushi Nakajima, Brent A. Neuschwander-Tetri, Zachary Goodman, Eric J. Lawitz, Stephen A. Harrison, et al. “EFFICACY AND SAFETY OF PEGBELFERMIN IN PATIENTS WITH NONALCOHOLIC STEATOHEPATITIS AND COMPENSATED CIRRHOSIS: RESULTS FROM THE PHASE 2b, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED FALCON 2 STUDY.” In Hepatology, 74:1396A-1397A, 2021.

Scholars@Duke

Harrison, Stephen A., Vlad Ratziu, Alexander White, Gary M. Reiss, William Kelly Bowman, Nadege Gunn, Veronique Loustaud Ratti, et al. “VONAFEXOR, A FXR AGONIST, INDUCED HEPATIC AND RENAL IMPROVEMENT IN THE RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED LIVIFY NASH TRIAL.” In Hepatology, 74:1383A-1384A, 2021.

Scholars@Duke

Loomba, Rohit, Arun J. Sanyal, Atsushi Nakajima, Brent A. Neuschwander-Tetri, Zachary Goodman, Stephen A. Harrison, Eric J. Lawitz, et al. “EFFICACY AND SAFETY OF PEGBELFERMIN IN PATIENTS WITH NONALCOHOLIC STEATOHEPATITIS AND STAGE 3 FIBROSIS: RESULTS FROM THE PHASE 2b, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED FALCON 1 STUDY.” In Hepatology, 74:1385A-1386A, 2021.

Scholars@Duke

Fudim, Marat, Lin Zhong, Kershaw V. Patel, Rohan Khera, Manal F. Abdelmalek, Anna Mae Diehl, Robert W. McGarrah, et al. “Nonalcoholic Fatty Liver Disease and Risk of Heart Failure Among Medicare Beneficiaries.” J Am Heart Assoc 10, no. 22 (November 16, 2021): e021654. https://doi.org/10.1161/JAHA.121.021654.

PMID
34755544
Full Text

Kanwal, Fasiha, Jay H. Shubrook, Leon A. Adams, Kim Pfotenhauer, Vincent Wai-Sun Wong, Eugene Wright, Manal F. Abdelmalek, et al. “Clinical Care Pathway for the Risk Stratification and Management of Patients With Nonalcoholic Fatty Liver Disease.” Gastroenterology 161, no. 5 (November 2021): 1657–69. https://doi.org/10.1053/j.gastro.2021.07.049.

PMID
34602251
Full Text

Salah, Husam M., Ambarish Pandey, Anzhela Soloveva, Manal F. Abdelmalek, Anna Mae Diehl, Cynthia A. Moylan, Kara Wegermann, et al. “Relationship of Nonalcoholic Fatty Liver Disease and Heart Failure With Preserved Ejection Fraction.” Jacc Basic Transl Sci 6, no. 11 (November 2021): 918–32. https://doi.org/10.1016/j.jacbts.2021.07.010.

PMID
34869957
Full Text

Glass, Oliver, Daniel Liu, Elizabeth Bechard, Cynthia D. Guy, Jane Pendergast, Anna Mae Diehl, and Manal F. Abdelmalek. “Perceptions of Exercise and Its Challenges in Patients With Nonalcoholic Fatty Liver Disease: A Survey-Based Study.” Hepatology Communications, October 26, 2021. https://doi.org/10.1002/hep4.1808.

PMID
34697917
Full Text

Francque, Sven M., Pierre Bedossa, Vlad Ratziu, Quentin M. Anstee, Elisabetta Bugianesi, Arun J. Sanyal, Rohit Loomba, et al. “A Randomized, Controlled Trial of the Pan-PPAR Agonist Lanifibranor in NASH.” N Engl J Med 385, no. 17 (October 21, 2021): 1547–58. https://doi.org/10.1056/NEJMoa2036205.

PMID
34670042
Full Text

Sanyal, Arun J., Quentin M. Anstee, Michael Trauner, Eric J. Lawitz, Manal F. Abdelmalek, Dora Ding, Ling Han, et al. “Cirrhosis Regression is Associated with Improved Clinical Outcomes in Patients with Nonalcoholic Steatohepatitis.” In Hepatology, 2021. https://doi.org/10.1002/hep.32204.

PMID
34662449
Full Text

Pages