Manal F. Abdelmalek, MD

Professor of Medicine
Campus mail 03119 Hosp South, Suite 03107, Room 03125, Durham, NC 27710
Phone (919) 684-3262
Email address manal.abdelmalek@duke.edu

My research interests include metabolic liver disease, particularly obesity-related liver disease and its association with complications of the insulin resistance syndrome. I am interested in studying the clinical, environmental, and genetic risk factors for nonalcoholic fatty liver disease, new therapeutic options for treatment, and evaluating the impact of NAFLD from a public health perspective.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Mayo School of Health Sciences, 1995 - 1998
  • Medical Resident, Medicine, Mayo School of Health Sciences, 1992 - 1995
  • M.D., University Missouri Kansas City, 1992

Publications

Vuppalanchi, R, Abdelmalek, MF, Lawitz, E, Traber, PG, Allgood, AE, Harrison, SA, Goodman, ZD, Chalasani, NP, and Garcia-Tsao, G. "Vibration-Controlled Transient Elastography (VCTE) is Useful in Identifying Clinically Significant Portal Hypertension in Patients with NASH Cirrhosis." October 2016.

Scholars@Duke

Corey, KE, Yates, KP, Abdelmalek, MF, Sanyal, AJ, Tetri, BA, Kowdley, KV, Cummings, O, Tonascia, J, and Chalasani, NP. "Longitudinal relationship between changes in liver histology and renal function in adults with NASH: The NASH Clinical Research Network Experience." October 2016.

Scholars@Duke

Patel, YA, Henao, R, Moylan, CA, Guy, CD, Piercy, DL, Diehl, AM, and Abdelmalek, MF. "Vitamin D is Not Associated with Histologic Severity in NAFLD: Results of a Paired Clinical and Hepatic Gene Expression Profile Analysis." October 2016.

Scholars@Duke

Klair, JS, Yang, JD, Abdelmalek, MF, Guy, CD, Gill, RM, Yates, K, Unalp-Arida, A, Lavine, JE, Clark, JM, Diehl, AM, Suzuki, A, and Nonalcoholic Steatohepatitis Clinical Research Network, . "A longer duration of estrogen deficiency increases fibrosis risk among postmenopausal women with nonalcoholic fatty liver disease." Hepatology (Baltimore, Md.) 64, no. 1 (July 2016): 85-91.

PMID
26919573
Full Text

Ratziu, V, Harrison, SA, Francque, S, Bedossa, P, Lehert, P, Serfaty, L, Romero-Gomez, M, Boursier, J, Abdelmalek, M, Caldwell, S, Drenth, J, Anstee, QM, Hum, D, Hanf, R, Roudot, A, Megnien, S, Staels, B, Sanyal, A, and GOLDEN-505 Investigator Study Group, . "Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening." Gastroenterology 150, no. 5 (May 2016): 1147-1159.e5.

PMID
26874076
Full Text

Thrasher, T, and Abdelmalek, MF. "Nonalcoholic Fatty Liver Disease." North Carolina medical journal 77, no. 3 (May 2016): 216-219.

PMID
27154894
Full Text

Zhu, R, Baker, SS, Moylan, CA, Abdelmalek, MF, Guy, CD, Zamboni, F, Wu, D, Lin, W, Liu, W, Baker, RD, Govindarajan, S, Cao, Z, Farci, P, Diehl, AM, and Zhu, L. "Systematic transcriptome analysis reveals elevated expression of alcohol-metabolizing genes in NAFLD livers." The Journal of pathology 238, no. 4 (March 2016): 531-542.

PMID
26415102
Full Text

Goodman, ZD, Alaparthi, L, Monge, F, Patel, K, Loomba, R, Caldwell, SH, Lawitz, E, Harrison, SA, Shiffman, ML, Abdelmalek, MF, Myers, RP, Schall, REA, Subramanian, M, McHutchison, JG, Ratziu, V, Sanyal, AJ, and Afdhal, NH. "Correlations between hepatic morphometric collagen content, histologic fibrosis staging, and serum markers in patients with advanced fibrosis due to nonalcoholic steatohepatitis (NASH)." October 2015.

Scholars@Duke

Harrison, SA, Sanyal, AJ, Francque, SM, Bedossa, P, Serfaty, L, Romero-Gomez, M, Cales, P, Abdelmalek, MF, Caldwell, SH, Drenth, J, Anstee, QM, Hum, DW, Hanf, R, Roudot, A, Megnien, S, Staels, B, and Ratziu, V. "Beneficial effects of the dual PPAR alpha-delta agonist, GFT505, on hepatic and cardiometabolic markers in adult NASH patients." October 2015.

Scholars@Duke

Chalasani, NP, Loomba, R, Terrault, N, McCullough, AJ, Abdelmalek, MF, Kowdley, KV, Neuschwander-Tetri, BA, Hazra, S, Yan, X, Shringarpure, R, MacConell, L, and Sanyal, AJ. "Longitudinal changes in FIB-4 and improvement in fibrosis stage with obeticholic acid: A secondary analysis of FLINT Trial." October 2015.

Scholars@Duke

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