Manal F. Abdelmalek, MD

Professor of Medicine
Campus mail 03119 Hosp South, Suite 03107, Room 03125, Durham, NC 27710
Phone (919) 684-3262
Email address manal.abdelmalek@duke.edu

My research interests include metabolic liver disease, particularly obesity-related liver disease and its association with complications of the insulin resistance syndrome. I am interested in studying the clinical, environmental, and genetic risk factors for nonalcoholic fatty liver disease, new therapeutic options for treatment, and evaluating the impact of NAFLD from a public health perspective.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Mayo School of Health Sciences, 1995 - 1998
  • Medical Resident, Medicine, Mayo School of Health Sciences, 1992 - 1995
  • M.D., University Missouri Kansas City, 1992

Publications

Wegermann, K, Henao, R, Diehl, AM, Murphy, SK, Abdelmalek, MF, and Moylan, CA. "Branched chain amino acid transaminase 1 (BCAT1) is overexpressed and hypomethylated in patients with non-alcoholic fatty liver disease who experience adverse clinical events: A pilot study." Plos One 13, no. 9 (January 2018): e0204308-null.

PMID
30265706
Full Text

Younossi, ZM, Stepanova, M, Sanyal, AJ, Harrison, SA, Ratziu, V, McColgan, BJ, Myers, RP, Subramanian, M, McHutchison, JG, Afdhal, NH, Abdelmalek, MF, Bosch, J, and Goodman, ZD. "Predictors of Fibrosis Progression and Regression by Histology and Morphometrically Quantified Collagen in Patients with Nonalcoholic Steatohepatitis (NASH) and Advanced Fibrosis." October 2017.

Scholars@Duke

Abdelmalek, MF, Thompson, M, Gathe, JC, Lefebvre, E, Seyedkazemi, S, Utay, NS, and Francque, S. "Favorable safety and tolerability of the dual CCR2/5 antagonist cenicriviroc in over 1000 subjects treated to date." October 2017.

Scholars@Duke

Abdelmalek, MF, Diehl, AM, Guy, CD, Portenier, D, Sudan, R, Li, X, Mimms, L, and Jain, A. "Serum-Based Biomarker Accurately Stratifies Hepatic Fibrosis in Patients with Nonalcoholic Steatohepatitis." October 2017.

Scholars@Duke

Guy, CD, Suzuki, A, Swiderska-Syn, M, Abdelmalek, MF, and Diehl, AM. "Hepatocellular injury and senescence in NASH are linked to Hedgehog and Hippo pathway activity and accumulation of hepatic progenitor cells." October 2017.

Scholars@Duke

Moylan, CA, Mavis, AM, Bashir, MR, Malik, D, Bozdogan, E, Buie, S, Hoyo, C, Diehl, AM, Murphy, SK, and Abdelmalek, MF. "Visceral and subcutaneous adipose tissue measurements associate with increased metabolic risk for NAFLD in pre-pubertal obese children." October 2017.

Scholars@Duke

Abdelmalek, MF, Henao, R, Wang, Y, Guy, CD, Bashir, MR, Johnson, R, Diehl, AM, and Soher, B. "Fructose-Related Hepatic ATP Depletion Induces Hyperuricemia in Healthy Volunteers and Patients with Biopsy-Proven Nonalcoholic Fatty Liver Disease." October 2017.

Scholars@Duke

Bosch, J, Harrison, SA, Abdelmalek, MF, Shiffman, ML, Diehl, AM, Caldwell, SH, Rockey, DC, Ghalib, R, Thuluvath, PJ, Schall, REA, Jia, C, McColgan, BJ, Myers, RP, Subramanian, M, McHutchison, JG, Afdhal, NH, Ratziu, V, Goodman, ZD, and Sanyal, AJ. "Hepatic venous pressure gradient (HVPG) predicts clinical disease progression in patients with compensated cirrhosis due to NASH." October 2017.

Scholars@Duke

Abdelmalek, MF, Charles, ED, Neuschwander-Tetri, BA, Halegoua-DeMarzio, D, Sanyal, AJ, Herring, RW, Lawitz, E, Dong, Y, Du, S, Gagnon, RC, Luo, Y, and Christian, R. "Baseline Serum Pro-C3 Predicts Response to BMS-986036 (peg-FGF21): A Secondary Analysis of a Multi-Center Clinical Trial in Non-Alcoholic Steatohepatitis (NASH)." October 2017.

Scholars@Duke

Vuppalanchi, R, Lawitz, E, Abdelmalek, MF, Rinella, ME, Harrison, SA, Ryan, MJ, Traber, PG, Garcia-Tsao, G, and Chalasani, NP. "Liver Stiffness Measured By Vibration Controlled Transient Elastography Is An Excellent Surrogate for Identifying Clinically Significant Portal Hypertension In Patients With Compensated NASH Cirrhosis." October 2017.

Scholars@Duke

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