Manal F. Abdelmalek, MD

Professor of Medicine
Campus mail 03119 Hosp South, Suite 03107, Room 03125, Durham, NC 27710
Phone (919) 684-3262
Email address manal.abdelmalek@duke.edu

My research interests include metabolic liver disease, particularly obesity-related liver disease and its association with complications of the insulin resistance syndrome. I am interested in studying the clinical, environmental, and genetic risk factors for nonalcoholic fatty liver disease, new therapeutic options for treatment, and evaluating the impact of NAFLD from a public health perspective.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Mayo School of Health Sciences, 1995 - 1998
  • Medical Resident, Medicine, Mayo School of Health Sciences, 1992 - 1995
  • M.D., University Missouri Kansas City, 1992

Publications

Moylan, CA, Giraldo, RH, Murphy, SK, Diehl, AM, and Abdelmalek, MF. "Differential DNA Methylation in Whole Blood Reflects that in Liver and Distinguishes Patients with Advanced NAFLD Fibrosis from Those with Normal Histology: A Potential Non-Invasive Tool." April 2017.

Full Text

Sanyal, A, Harrison, SA, Ratziu, V, Abdelmalek, MF, Diehl, AM, Caldwell, SH, Shiffman, ML, Aguilar, R, Jia, C, McColgan, BJ, Natha, M, Myers, RP, Subramanian, M, McHutchison, J, Muir, AJ, Afdhal, NH, Bosch, J, and Goodman, Z. "Changes in Fibrosis, but not the Nafld Activity Score (NAS), are Associated with Disease Progression in Patients with Nonalcoholic Steatohepatitis (NASH) and Advanced Fibrosis." April 2017.

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Yang, JD, AbdelmaleK, MF, Guy, CD, Diehl, AM, and Suzuki, A. "Reply(Accepted)." Clinical Gastroenterology and Hepatology (January 1, 2017).

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Yang, JD, Abdelmalek, MF, Guy, CD, Gill, RM, Lavine, JE, Yates, K, Klair, J, Terrault, NA, Clark, JM, Unalp-Arida, A, Diehl, AM, Suzuki, A, and Nonalcoholic Steatohepatitis Clinical Research Network, . "Patient Sex, Reproductive Status, and Synthetic Hormone Use Associate With Histologic Severity of Nonalcoholic Steatohepatitis." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association 15, no. 1 (January 2017): 127-131.e2.

PMID
27523635
Full Text

Nelson, JE, Handa, P, Aouizerat, B, Wilson, L, Vemulakonda, LA, Yeh, MM, Kowdley, KV, and NASH Clinical Research Network, . "Increased parenchymal damage and steatohepatitis in Caucasian non-alcoholic fatty liver disease patients with common IL1B and IL6 polymorphisms." Alimentary pharmacology & therapeutics 44, no. 11-12 (December 2016): 1253-1264.

PMID
27730688
Full Text

Abdelmalek, MF. "NAFLD: The clinical and economic burden of NAFLD: time to turn the tide." Nature reviews. Gastroenterology & hepatology 13, no. 12 (December 2016): 685-686.

PMID
27826139
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Sanyal, AJ, Ratziu, V, Harrison, S, Abdelmalek, MF, Aithal, GP, Caballeria, J, Francque, SM, Farrell, GC, Kowdley, KV, Craxi, A, Simon, K, Fischer, L, Melchor-Khan, L, Vest, J, Wiens, BL, Vig, P, Seyedkazemi, S, Goodman, ZD, Wong, VW, Loomba, R, Tacke, F, Friedman, SL, and Lefebvre, E. "Cenicriviroc placebo for the treatment of non-alcoholic steatohepatitis with liver fibrosis: Results from the Year 1 primary analysis of the Phase 2b CENTAUR study Abstracts." December 2016.

Scholars@Duke

Patel, YA, Henao, R, Moylan, CA, Guy, CD, Piercy, DL, Diehl, AM, and Abdelmalek, MF. "Vitamin D is Not Associated With Severity in NAFLD: Results of a Paired Clinical and Gene Expression Profile Analysis." The American Journal of Gastroenterology 111, no. 11 (November 2016): 1591-1598.

PMID
27644736
Full Text

Suzuki, A, Spencer, HJ, Moylan, CA, Dranoff, JA, Abdelmalek, MF, Guy, CD, and Diehl, AM. "Hepatic estrogen transcriptional activity and estrogen receptor a gene expression are negatively correlated with fibrosis stage in patients with nonalcoholic fatty liver disease (NAFLD)." October 2016.

Scholars@Duke

Wegermann, K, Henao, R, Pan, Y, Diehl, AM, Abdelmalek, MF, and Moylan, CA. "BCAT1 is Associated with Clinical Decompensation in NAFLD: A Pilot Study." October 2016.

Scholars@Duke

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