Manal F. Abdelmalek, MD

Professor of Medicine
Campus mail 03119 Hosp South, Suite 03107, Room 03125, Durham, NC 27710
Phone (919) 684-3262
Email address manal.abdelmalek@duke.edu

My research interests include metabolic liver disease, particularly obesity-related liver disease and its association with complications of the insulin resistance syndrome. I am interested in studying the clinical, environmental, and genetic risk factors for nonalcoholic fatty liver disease, new therapeutic options for treatment, and evaluating the impact of NAFLD from a public health perspective.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Mayo School of Health Sciences, 1995 - 1998
  • Medical Resident, Medicine, Mayo School of Health Sciences, 1992 - 1995
  • M.D., University Missouri Kansas City, 1992

Publications

Moylan, CA, Mavis, AM, Bashir, MR, Malik, D, Bozdogan, E, Buie, S, Hoyo, C, Diehl, AM, Murphy, SK, and Abdelmalek, MF. "Visceral and subcutaneous adipose tissue measurements associate with increased metabolic risk for NAFLD in pre-pubertal obese children." October 2017.

Scholars@Duke

Abdelmalek, MF, Henao, R, Wang, Y, Guy, CD, Bashir, MR, Johnson, R, Diehl, AM, and Soher, B. "Fructose-Related Hepatic ATP Depletion Induces Hyperuricemia in Healthy Volunteers and Patients with Biopsy-Proven Nonalcoholic Fatty Liver Disease." October 2017.

Scholars@Duke

Bosch, J, Harrison, SA, Abdelmalek, MF, Shiffman, ML, Diehl, AM, Caldwell, SH, Rockey, DC, Ghalib, R, Thuluvath, PJ, Schall, REA, Jia, C, McColgan, BJ, Myers, RP, Subramanian, M, McHutchison, JG, Afdhal, NH, Ratziu, V, Goodman, ZD, and Sanyal, AJ. "Hepatic venous pressure gradient (HVPG) predicts clinical disease progression in patients with compensated cirrhosis due to NASH." October 2017.

Scholars@Duke

Abdelmalek, MF, Charles, ED, Neuschwander-Tetri, BA, Halegoua-DeMarzio, D, Sanyal, AJ, Herring, RW, Lawitz, E, Dong, Y, Du, S, Gagnon, RC, Luo, Y, and Christian, R. "Baseline Serum Pro-C3 Predicts Response to BMS-986036 (peg-FGF21): A Secondary Analysis of a Multi-Center Clinical Trial in Non-Alcoholic Steatohepatitis (NASH)." October 2017.

Scholars@Duke

Vuppalanchi, R, Lawitz, E, Abdelmalek, MF, Rinella, ME, Harrison, SA, Ryan, MJ, Traber, PG, Garcia-Tsao, G, and Chalasani, NP. "Liver Stiffness Measured By Vibration Controlled Transient Elastography Is An Excellent Surrogate for Identifying Clinically Significant Portal Hypertension In Patients With Compensated NASH Cirrhosis." October 2017.

Scholars@Duke

Rinella, ME, Trotter, JF, Neff, G, Ortiz-Lasanta, G, Abdelmalek, MF, Kugelmas, M, Paredes, AH, Connelly, MA, Ling, L, Rossi, SJ, DePaoli, AM, Loomba, R, and Harrison, SA. "NGM282 Induces Low Density Lipoprotein Cholesterol (LDLc) Changes, Consistent with Potent FGFR4 Signaling, which are Rapidly Mitigated with Statin Therapy in Patients with Biopsy-Confirmed Nonalcoholic Steatohepatitis (NASH)." October 2017.

Scholars@Duke

Loomba, R, Abdelmalek, MF, Trotter, JF, Paredes, AH, Jaros, M, Ling, L, Rossi, SJ, DePaoli, AM, Rinella, ME, and Harrison, SA. "NGM282 Significantly Reduces Hepatic Steatosis Independent of Baseline Patient Characteristics and Highly Correlates with Markers of FGFR4 Target Engagement: Results from a Phase 2 Trial in Biopsy-Confirmed NASH Patients." October 2017.

Scholars@Duke

Goodman, ZD, Alaparthi, L, Monge, F, Patel, K, Loomba, R, Caldwell, SH, Lawitz, E, Shiffman, ML, Abdelmalek, MF, Schall, REA, Jia, C, McColgan, BJ, Myers, RP, Ratziu, V, Afdhal, NH, Harrison, SA, and Sanyal, AJ. "Prospective validation of hepatic collagen content for the prediction of clinical disease progression." October 2017.

Scholars@Duke

Loomba, R, Lawitz, E, Ghalib, R, Elkhashab, M, Caldwell, SH, Abdelmalek, MF, Kowdley, KV, Xu, R, Han, L, Li, Y, Djedjos, CS, Myers, RP, Subramanian, M, Goodman, ZD, Charlton, M, Sirlin, CB, and Middleton, MS. "Reductions in liver stiffness by magnetic resonance elastography (MRE) predict fibrosis improvement in a multi-center clinical trial of subjects with nonalcoholic steatohepatitis (NASH)." October 2017.

Scholars@Duke

Newton, KP, Feldman, HS, Chambers, CD, Wilson, L, Behling, C, Clark, JM, Molleston, JP, Chalasani, N, Sanyal, AJ, Fishbein, MH, Lavine, JE, Schwimmer, JB, and Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), . "Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children." The Journal of Pediatrics 187 (August 2017): 141-146.e1.

PMID
28366357
Full Text

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