Manal F. Abdelmalek, MD

Professor of Medicine
Campus mail 03119 Hosp South, Suite 03107, Room 03125, Durham, NC 27710
Phone (919) 684-3262
Email address manal.abdelmalek@duke.edu

My research interests include metabolic liver disease, particularly obesity-related liver disease and its association with complications of the insulin resistance syndrome. I am interested in studying the clinical, environmental, and genetic risk factors for nonalcoholic fatty liver disease, new therapeutic options for treatment, and evaluating the impact of NAFLD from a public health perspective.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Mayo School of Health Sciences, 1995 - 1998
  • Medical Resident, Medicine, Mayo School of Health Sciences, 1992 - 1995
  • M.D., University Missouri Kansas City, 1992

Publications

Younossi, ZM, Loomba, R, Rinella, ME, Bugianesi, E, Marchesini, G, Neuschwander-Tetri, BA, Serfaty, L, Negro, F, Caldwell, SH, Ratziu, V, Corey, KE, Friedman, SL, Abdelmalek, MF, Harrison, SA, Sanyal, AJ, Lavine, JE, Mathurin, P, Charlton, MR, Chalasani, NP, Anstee, QM, Kowdley, KV, George, J, Goodman, ZD, and Lindor, K. "Current and future therapeutic regimens for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis." Hepatology (Baltimore, Md.) 68, no. 1 (July 2018): 361-371.

PMID
29222911
Full Text

Friedman, SL, Ratziu, V, Harrison, SA, Abdelmalek, MF, Aithal, GP, Caballeria, J, Francque, S, Farrell, G, Kowdley, KV, Craxi, A, Simon, K, Fischer, L, Melchor-Khan, L, Vest, J, Wiens, BL, Vig, P, Seyedkazemi, S, Goodman, Z, Wong, VW-S, Loomba, R, Tacke, F, Sanyal, A, and Lefebvre, E. "A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis." Hepatology (Baltimore, Md.) 67, no. 5 (May 2018): 1754-1767.

PMID
28833331
Full Text

Siddiqui, MS, Harrison, SA, Abdelmalek, MF, Anstee, QM, Bedossa, P, Castera, L, Dimick-Santos, L, Friedman, SL, Greene, K, Kleiner, DE, Megnien, S, Neuschwander-Tetri, BA, Ratziu, V, Schabel, E, Miller, V, Sanyal, AJ, and Liver Forum Case Definitions Working Group, . "Case definitions for inclusion and analysis of endpoints in clinical trials for nonalcoholic steatohepatitis through the lens of regulatory science." Hepatology (Baltimore, Md.) 67, no. 5 (May 2018): 2001-2012.

PMID
29059456
Full Text

Jensen, T, Abdelmalek, MF, Sullivan, S, Nadeau, KJ, Green, M, Roncal, C, Nakagawa, T, Kuwabara, M, Sato, Y, Kang, D-H, Tolan, DR, Sanchez-Lozada, LG, Rosen, HR, Lanaspa, MA, Diehl, AM, and Johnson, RJ. "Fructose and sugar: A major mediator of non-alcoholic fatty liver disease." Journal of Hepatology 68, no. 5 (May 2018): 1063-1075. (Review)

PMID
29408694
Full Text

Harrison, SA, Rinella, ME, Abdelmalek, MF, Trotter, JF, Paredes, AH, Arnold, HL, Kugelmas, M, Bashir, MR, Jaros, MJ, Ling, L, Rossi, SJ, DePaoli, AM, and Loomba, R. "NGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial." Lancet (London, England) 391, no. 10126 (March 5, 2018): 1174-1185.

PMID
29519502
Full Text

de Ridder, G, Suzuki, A, Xu, L, Cardona, D, Groth, J, Ray, R, Abdelmalek, MF, Pizzo, SV, and Guy, C. "GRP78 Immunohistochemistry Outperforms HSP70 for the Diagnosis of Cirrhotic- and Noncirrhotic-HCC." 107th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP). Vancouver, CANADA. March 17, 2018 - March 23, 2018.: NATURE PUBLISHING GROUP, March 1, 2018.

Scholars@Duke

de Ridder, G, Suzuki, A, Xu, L, Cardona, D, Groth, J, Ray, R, Abdelmalek, MF, Pizzo, SV, and Guy, C. "GRP78 Immunohistochemistry Outperforms HSP70 for the Diagnosis of Cirrhotic- and Noncirrhotic-HCC." 107th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP). Vancouver, CANADA. March 17, 2018 - March 23, 2018.: NATURE PUBLISHING GROUP, March 1, 2018.

Scholars@Duke

Schild, M, Xu, L, Suzuki, A, Cardona, D, Clinton, L, McCall, S, Pendse, A, Zhang, X, Abdelmalek, MF, Diehl, AM, and Guy, C. "Sonic Hedgehog Immunohistochemistry Improves Inter-observer Agreement for Ballooning and the Diagnosis of Nonalcoholic Steatohepatitis (NASH) among Less Experienced Liver Pathologists." 107th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP). Vancouver, CANADA. March 17, 2018 - March 23, 2018.: NATURE PUBLISHING GROUP, March 1, 2018.

Scholars@Duke

Schild, M, Xu, L, Suzuki, A, Cardona, D, Clinton, L, McCall, S, Pendse, A, Zhang, X, Abdelmalek, MF, Diehl, AM, and Guy, C. "Sonic Hedgehog Immunohistochemistry Improves Inter-observer Agreement for Ballooning and the Diagnosis of Nonalcoholic Steatohepatitis (NASH) among Less Experienced Liver Pathologists." 107th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP). Vancouver, CANADA. March 17, 2018 - March 23, 2018.: NATURE PUBLISHING GROUP, March 1, 2018.

Scholars@Duke

Vuppalanchi, R, Siddiqui, MS, Van Natta, ML, Hallinan, E, Brandman, D, Kowdley, K, Neuschwander-Tetri, BA, Loomba, R, Dasarathy, S, Abdelmalek, M, Doo, E, Tonascia, JA, Kleiner, DE, Sanyal, AJ, Chalasani, N, and NASH Clinical Research Network, . "Performance characteristics of vibration-controlled transient elastography for evaluation of nonalcoholic fatty liver disease." Hepatology (Baltimore, Md.) 67, no. 1 (January 2018): 134-144.

PMID
28859228
Full Text

Pages