Manal F. Abdelmalek, MD

Professor of Medicine
Campus mail 03119 Hosp South, Suite 03107, Room 03125, Durham, NC 27710
Phone (919) 684-3262
Email address manal.abdelmalek@duke.edu

My research interests include metabolic liver disease, particularly obesity-related liver disease and its association with complications of the insulin resistance syndrome. I am interested in studying the clinical, environmental, and genetic risk factors for nonalcoholic fatty liver disease, new therapeutic options for treatment, and evaluating the impact of NAFLD from a public health perspective.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Mayo School of Health Sciences, 1995 - 1998
  • Medical Resident, Medicine, Mayo School of Health Sciences, 1992 - 1995
  • M.D., University Missouri Kansas City, 1992

Publications

Patel, YA, Henao, R, Moylan, CA, Guy, CD, Piercy, DL, Diehl, AM, and Abdelmalek, MF. "Vitamin D is Not Associated with Histologic Severity in NAFLD: Results of a Paired Clinical and Hepatic Gene Expression Profile Analysis." October 2016.

Scholars@Duke

Moylan, CA, Wegermann, KJ, Henao, RG, Murphy, SK, Diehl, AM, and Abdelmalek, MF. "BCAT1 Is Associated with Clinical Decompensation in Nonalcoholic Fatty Liver Disease: a Pilot Study." October 2016.

Scholars@Duke

Suzuki, A, Spencer, HJ, Moylan, CA, Dranoff, JA, Abdelmalek, MF, Guy, CD, and Diehl, AM. "Hepatic estrogen transcriptional activity and estrogen receptor a gene expression are negatively correlated with fibrosis stage in patients with nonalcoholic fatty liver disease (NAFLD)." October 2016.

Scholars@Duke

Wegermann, K, Henao, R, Pan, Y, Diehl, AM, Abdelmalek, MF, and Moylan, CA. "BCAT1 is Associated with Clinical Decompensation in NAFLD: A Pilot Study." October 2016.

Scholars@Duke

Klair, JS, Yang, JD, Abdelmalek, MF, Guy, CD, Gill, RM, Yates, K, Unalp-Arida, A, Lavine, JE, Clark, JM, Diehl, AM, Suzuki, A, and Nonalcoholic Steatohepatitis Clinical Research Network, . "A longer duration of estrogen deficiency increases fibrosis risk among postmenopausal women with nonalcoholic fatty liver disease." Hepatology (Baltimore, Md.) 64, no. 1 (July 2016): 85-91.

PMID
26919573
Full Text

Ratziu, V, Harrison, SA, Francque, S, Bedossa, P, Lehert, P, Serfaty, L, Romero-Gomez, M, Boursier, J, Abdelmalek, M, Caldwell, S, Drenth, J, Anstee, QM, Hum, D, Hanf, R, Roudot, A, Megnien, S, Staels, B, Sanyal, A, and GOLDEN-505 Investigator Study Group, . "Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening." Gastroenterology 150, no. 5 (May 2016): 1147-1159.e5.

PMID
26874076
Full Text

Thrasher, T, and Abdelmalek, MF. "Nonalcoholic Fatty Liver Disease." North Carolina medical journal 77, no. 3 (May 2016): 216-219.

PMID
27154894
Full Text

Kowdley, KV, Abdelmalek, MF, McCullough, A, Loomba, R, Hameed, B, Chalasani, NP, Neuschwander-Tetri, B, Hazra, S, Chen, J, Shringapure, R, Shapiro, D, and Sanyal, AJ. "Mo1557 Evaluation of Effects of Concomitant Medications for NASH and Associated Comorbidities on Histological Improvements With Obeticholic Acid." April 2016.

Full Text

Zhu, R, Baker, SS, Moylan, CA, Abdelmalek, MF, Guy, CD, Zamboni, F, Wu, D, Lin, W, Liu, W, Baker, RD, Govindarajan, S, Cao, Z, Farci, P, Diehl, AM, and Zhu, L. "Systematic transcriptome analysis reveals elevated expression of alcohol-metabolizing genes in NAFLD livers." The Journal of pathology 238, no. 4 (March 2016): 531-542.

PMID
26415102
Full Text

Ratziu, V, Sanyal, AJ, Loomba, R, Caldwell, SH, Ghalib, RH, Torres, DM, McCullough, AJ, Muir, AJ, Myers, RP, Schall, REA, Subramanian, M, McHutchison, JG, Bosch, J, Harrison, SA, and Abdelmalek, MF. "Characterization of insulin resistance in patients with advanced fibrosis due to nonalcoholic steatohepatitis (NASH)." October 2015.

Scholars@Duke

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