Manal F. Abdelmalek, MD

Professor of Medicine
Campus mail 03119 Hosp South, Suite 03107, Room 03125, Durham, NC 27710
Phone (919) 684-3262
Email address manal.abdelmalek@duke.edu

My research interests include metabolic liver disease, particularly obesity-related liver disease and its association with complications of the insulin resistance syndrome. I am interested in studying the clinical, environmental, and genetic risk factors for nonalcoholic fatty liver disease, new therapeutic options for treatment, and evaluating the impact of NAFLD from a public health perspective.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Mayo School of Health Sciences, 1995 - 1998
  • Medical Resident, Medicine, Mayo School of Health Sciences, 1992 - 1995
  • M.D., University Missouri Kansas City, 1992

Publications

Wegermann, K, Henao, R, Diehl, AM, Murphy, SK, Abdelmalek, MF, and Moylan, CA. "Branched chain amino acid transaminase 1 (BCAT1) is overexpressed and hypomethylated in patients with non-alcoholic fatty liver disease who experience adverse clinical events: A pilot study." Plos One 13, no. 9 (January 2018): e0204308-null.

PMID
30265706
Full Text

Rinella, ME, Trotter, JF, Neff, G, Ortiz-Lasanta, G, Abdelmalek, MF, Kugelmas, M, Paredes, AH, Connelly, MA, Ling, L, Rossi, SJ, DePaoli, AM, Loomba, R, and Harrison, SA. "NGM282 Induces Low Density Lipoprotein Cholesterol (LDLc) Changes, Consistent with Potent FGFR4 Signaling, which are Rapidly Mitigated with Statin Therapy in Patients with Biopsy-Confirmed Nonalcoholic Steatohepatitis (NASH)." October 2017.

Scholars@Duke

Loomba, R, Abdelmalek, MF, Trotter, JF, Paredes, AH, Jaros, M, Ling, L, Rossi, SJ, DePaoli, AM, Rinella, ME, and Harrison, SA. "NGM282 Significantly Reduces Hepatic Steatosis Independent of Baseline Patient Characteristics and Highly Correlates with Markers of FGFR4 Target Engagement: Results from a Phase 2 Trial in Biopsy-Confirmed NASH Patients." October 2017.

Scholars@Duke

Goodman, ZD, Alaparthi, L, Monge, F, Patel, K, Loomba, R, Caldwell, SH, Lawitz, E, Shiffman, ML, Abdelmalek, MF, Schall, REA, Jia, C, McColgan, BJ, Myers, RP, Ratziu, V, Afdhal, NH, Harrison, SA, and Sanyal, AJ. "Prospective validation of hepatic collagen content for the prediction of clinical disease progression." October 2017.

Scholars@Duke

Loomba, R, Lawitz, E, Ghalib, R, Elkhashab, M, Caldwell, SH, Abdelmalek, MF, Kowdley, KV, Xu, R, Han, L, Li, Y, Djedjos, CS, Myers, RP, Subramanian, M, Goodman, ZD, Charlton, M, Sirlin, CB, and Middleton, MS. "Reductions in liver stiffness by magnetic resonance elastography (MRE) predict fibrosis improvement in a multi-center clinical trial of subjects with nonalcoholic steatohepatitis (NASH)." October 2017.

Scholars@Duke

Li, X, Moylan, CA, Baker, SS, Liu, W, Baker, RD, Murphy, SK, Abdelmalek, MF, Zhu, R, Diehl, AM, and Zhu, L. "Altered liver methylome and transcriptome provide evidence for epigenetic contribution to NAFLD pathogenesis." October 2017.

Scholars@Duke

Younossi, ZM, Stepanova, M, Harrison, SA, Sanyal, AJ, Ratziu, V, McColgan, BJ, Myers, RP, Subramanian, M, McHutchison, JG, Afdhal, NH, Abdelmalek, MF, Bosch, J, and Goodman, ZD. "Subjects with Non-alcoholic Fatty Liver Disease and Severe Fibrosis Face a Significant Number of Adverse Events: Cryptogenic Cirrhosis and Severe Steatofibrosis." October 2017.

Scholars@Duke

Bosch, J, Abdelmalek, MF, Shiffman, ML, Diehl, AM, Caldwell, SH, Rockey, DC, Ghalib, R, Thuluvath, PJ, Harrison, SA, Schall, REA, Jia, C, McColgan, BJ, Myers, RP, Subramanian, M, McHutchison, JG, Afdhal, NH, Ratziu, V, Goodman, ZD, and Sanyal, AJ. "Variability in measurement of hepatic venous pressure gradient (HVPG) in patients with compensated cirrhosis due to NASH: Results from a randomized, controlled trial." October 2017.

Scholars@Duke

Sanyal, AJ, Charles, ED, Neuschwander-Tetri, BA, Loomba, R, Harrison, SA, Abdelmalek, MF, Lawitz, E, Halegoua-DeMarzio, D, Dong, Y, Noviello, S, Luo, Y, and Christian, R. "BMS-986036 (pegylated FGF21) in patients with non-alcoholic steatohepatitis: A phase 2 study." October 2017.

Scholars@Duke

Wegermann, K, Moylan, CA, Zheng, J, Abdelmalek, MF, Chow, S-C, Guy, CD, Diehl, AM, and Suzuki, A. "Gender and menopause significantly modify effects of metabolism-related SNPs on fibrosis stage in adult patients with nonalcoholic fatty liver disease (NAFLD)." October 2017.

Scholars@Duke

Pages