Manal F. Abdelmalek, MD

Professor of Medicine
Campus mail 03119 Hosp South, Suite 03107, Room 03125, Durham, NC 27710
Phone (919) 684-3262
Email address manal.abdelmalek@duke.edu

My research interests include metabolic liver disease, particularly obesity-related liver disease and its association with complications of the insulin resistance syndrome. I am interested in studying the clinical, environmental, and genetic risk factors for nonalcoholic fatty liver disease, new therapeutic options for treatment, and evaluating the impact of NAFLD from a public health perspective.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Mayo School of Health Sciences, 1995 - 1998
  • Medical Resident, Medicine, Mayo School of Health Sciences, 1992 - 1995
  • M.D., University Missouri Kansas City, 1992

Publications

Bohinc, BN, Michelotti, G, Xie, G, Pang, H, Suzuki, A, Guy, CD, Piercy, D, Kruger, L, Swiderska-Syn, M, Machado, M, Pereira, T, Zavacki, AM, Abdelmalek, M, and Diehl, AM. "Repair-related activation of hedgehog signaling in stromal cells promotes intrahepatic hypothyroidism." Endocrinology 155, no. 11 (November 2014): 4591-4601.

PMID
25121996
Full Text

Sanyal, AJ, Abdelmalek, MF, Suzuki, A, Cummings, OW, Chojkier, M, and EPE-A Study Group, . "No significant effects of ethyl-eicosapentanoic acid on histologic features of nonalcoholic steatohepatitis in a phase 2 trial." Gastroenterology 147, no. 2 (August 2014): 377-84.e1.

PMID
24818764
Full Text

Siddique, A, Nelson, JE, Aouizerat, B, Yeh, MM, Kowdley, KV, and NASH Clinical Research Network, . "Iron deficiency in patients with nonalcoholic Fatty liver disease is associated with obesity, female gender, and low serum hepcidin." Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 12, no. 7 (July 2014): 1170-1178.

PMID
24269922
Full Text

Kochhar, S, Abdelmalek, MF, Guy, CD, Piercy, D, Pan, Y, Diehl, AM, and Suzuki, A. "Associations of Sleep Duration and Sleep Quality With Clinical and Histologic Features of Nonalcoholic Fatty Liver Disease (NAFLD)." May 2014.

Scholars@Duke

Yang, JD, Abdelmalek, MF, Guy, CD, Gill, RM, Yates, KP, Unalp, A, Lavine, JE, Diehl, AM, and Suzuki, A. "Associations of Sex and Menopause With Histologic Severity of Necroinflammation and Portal Inflammation Among Patients With Nonalcoholic Fatty Liver Disease (NAFLD)." May 2014.

Scholars@Duke

Gadd, VL, Skoien, R, Powell, EE, Fagan, KJ, Winterford, C, Horsfall, L, Irvine, K, and Clouston, AD. "The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease." Hepatology 59, no. 4 (April 2014): 1393-1405.

Full Text

Moylan, CA, Pang, H, Dellinger, A, Suzuki, A, Garrett, ME, Guy, CD, Murphy, SK, Ashley-Koch, AE, Choi, SS, Michelotti, GA, Hampton, DD, Chen, Y, Tillmann, HL, Hauser, MA, Abdelmalek, MF, and Diehl, AM. "Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease." Hepatology 59, no. 2 (February 2014): 471-482.

PMID
23913408
Full Text

Urban, TJ, Moylan, CA, Rein, M, Abdelmalek, MF, Goldstein, DB, and Diehl, AM. "Whole Exome Sequencing of Extreme Phenotypes of NAFLD Identifies Potential Genetic Risk Factors for Advanced Hepatic Fibrosis." 2014.

Scholars@Duke

Klair, JS, Yang, JD, Abdelmalek, MF, Guy, CD, Gill, RM, Yates, KP, Unalp-Arida, A, Lavine, JE, Clark, JM, Diehl, AM, and Suzuki, A. "Risk of severe fibrosis is associated with age at menopause in nonalcoholic fatty liver disease (NAFLD)." 2014.

Scholars@Duke

Bohinc, B, Michelotti, GA, Xie, G, Pang, H, Suzuki, A, Guy, CD, Piercy, DL, Kruger, L, Swiderska-Syn, M, Machado, MV, Pereira, TA, Zavacki, AM, Abdelmalek, MF, and Diehl, AM. "Repair-related Activation of Hedgehog Signaling in Stromal Cells Promotes Intrahepatic Hypothyroidism." 2014.

Scholars@Duke

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