Gastroenterology

Manal F. Abdelmalek, MD

Professor of Medicine
Campus mail 03119 Hosp South, Suite 03107, Room 03125, Durham, NC 27710
Phone (919) 684-3262
Email address manal.abdelmalek@duke.edu

My research interests include metabolic liver disease, particularly obesity-related liver disease and its association with complications of the insulin resistance syndrome. I am interested in studying the clinical, environmental, and genetic risk factors for nonalcoholic fatty liver disease, new therapeutic options for treatment, and evaluating the impact of NAFLD from a public health perspective.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Mayo School of Health Sciences, 1995 - 1998
  • Medical Resident, Medicine, Mayo School of Health Sciences, 1992 - 1995
  • M.D., University Missouri Kansas City, 1992

Grants

Publications

Younossi, ZM, Stepanova, M, Harrison, SA, Sanyal, AJ, Ratziu, V, McColgan, BJ, Myers, RP, Subramanian, M, McHutchison, JG, Afdhal, NH, Abdelmalek, MF, Bosch, J, and Goodman, ZD. "Subjects with Non-alcoholic Fatty Liver Disease and Severe Fibrosis Face a Significant Number of Adverse Events: Cryptogenic Cirrhosis and Severe Steatofibrosis." October 2017.

Scholars@Duke

Bosch, J, Abdelmalek, MF, Shiffman, ML, Diehl, AM, Caldwell, SH, Rockey, DC, Ghalib, R, Thuluvath, PJ, Harrison, SA, Schall, REA, Jia, C, McColgan, BJ, Myers, RP, Subramanian, M, McHutchison, JG, Afdhal, NH, Ratziu, V, Goodman, ZD, and Sanyal, AJ. "Variability in measurement of hepatic venous pressure gradient (HVPG) in patients with compensated cirrhosis due to NASH: Results from a randomized, controlled trial." October 2017.

Scholars@Duke

Sanyal, AJ, Charles, ED, Neuschwander-Tetri, BA, Loomba, R, Harrison, SA, Abdelmalek, MF, Lawitz, E, Halegoua-DeMarzio, D, Dong, Y, Noviello, S, Luo, Y, and Christian, R. "BMS-986036 (pegylated FGF21) in patients with non-alcoholic steatohepatitis: A phase 2 study." October 2017.

Scholars@Duke

Wegermann, K, Moylan, CA, Zheng, J, Abdelmalek, MF, Chow, S-C, Guy, CD, Diehl, AM, and Suzuki, A. "Gender and menopause significantly modify effects of metabolism-related SNPs on fibrosis stage in adult patients with nonalcoholic fatty liver disease (NAFLD)." October 2017.

Scholars@Duke

Harrison, SA, Abdelmalek, MF, Diehl, AM, Caldwell, S, Shiffman, ML, Ghalib, R, Lawitz, E, Rockey, DC, Schall, REA, Jia, C, McColgan, BJ, Myers, RP, Subramanian, M, McHutchison, JG, Muir, AJ, Ratziu, V, Afdhal, NH, Goodman, ZD, Bosch, J, and Sanyal, AJ. "Prospective validation of the Enhanced Liver Fibrosis (ELF) test for the prediction of disease progression in patients with nonalcoholic steatohepatitis (NASH) and advanced fibrosis." October 2017.

Scholars@Duke

Younossi, ZM, Stepanova, M, Sanyal, AJ, Harrison, SA, Ratziu, V, McColgan, BJ, Myers, RP, Subramanian, M, McHutchison, JG, Afdhal, NH, Abdelmalek, MF, Bosch, J, and Goodman, ZD. "Predictors of Fibrosis Progression and Regression by Histology and Morphometrically Quantified Collagen in Patients with Nonalcoholic Steatohepatitis (NASH) and Advanced Fibrosis." October 2017.

Scholars@Duke

Abdelmalek, MF, Thompson, M, Gathe, JC, Lefebvre, E, Seyedkazemi, S, Utay, NS, and Francque, S. "Favorable safety and tolerability of the dual CCR2/5 antagonist cenicriviroc in over 1000 subjects treated to date." October 2017.

Scholars@Duke

Abdelmalek, MF, Diehl, AM, Guy, CD, Portenier, D, Sudan, R, Li, X, Mimms, L, and Jain, A. "Serum-Based Biomarker Accurately Stratifies Hepatic Fibrosis in Patients with Nonalcoholic Steatohepatitis." October 2017.

Scholars@Duke

Guy, CD, Suzuki, A, Swiderska-Syn, M, Abdelmalek, MF, and Diehl, AM. "Hepatocellular injury and senescence in NASH are linked to Hedgehog and Hippo pathway activity and accumulation of hepatic progenitor cells." October 2017.

Scholars@Duke

Moylan, CA, Mavis, AM, Bashir, MR, Malik, D, Bozdogan, E, Buie, S, Hoyo, C, Diehl, AM, Murphy, SK, and Abdelmalek, MF. "Visceral and subcutaneous adipose tissue measurements associate with increased metabolic risk for NAFLD in pre-pubertal obese children." October 2017.

Scholars@Duke

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