Manal F. Abdelmalek, MD

Professor of Medicine
Campus mail 03119 Hosp South, Suite 03107, Room 03125, Durham, NC 27710
Phone (919) 684-3262
Email address manal.abdelmalek@duke.edu

My research interests include metabolic liver disease, particularly obesity-related liver disease and its association with complications of the insulin resistance syndrome. I am interested in studying the clinical, environmental, and genetic risk factors for nonalcoholic fatty liver disease, new therapeutic options for treatment, and evaluating the impact of NAFLD from a public health perspective.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Mayo School of Health Sciences, 1995 - 1998
  • Medical Resident, Medicine, Mayo School of Health Sciences, 1992 - 1995
  • M.D., University Missouri Kansas City, 1992

Publications

Harrison, SA, Sanyal, AJ, Francque, SM, Bedossa, P, Serfaty, L, Romero-Gomez, M, Cales, P, Abdelmalek, MF, Caldwell, SH, Drenth, J, Anstee, QM, Hum, DW, Hanf, R, Roudot, A, Megnien, S, Staels, B, and Ratziu, V. "Beneficial effects of the dual PPAR alpha-delta agonist, GFT505, on hepatic and cardiometabolic markers in adult NASH patients." October 2015.

Scholars@Duke

Chalasani, NP, Loomba, R, Terrault, N, McCullough, AJ, Abdelmalek, MF, Kowdley, KV, Neuschwander-Tetri, BA, Hazra, S, Yan, X, Shringarpure, R, MacConell, L, and Sanyal, AJ. "Longitudinal changes in FIB-4 and improvement in fibrosis stage with obeticholic acid: A secondary analysis of FLINT Trial." October 2015.

Scholars@Duke

Harrison, SA, Goodman, ZD, Ratziu, V, Loomba, R, Diehl, AM, Lawitz, E, Hinrichsen, H, Bambha, K, Abdelmalek, MF, Myers, RP, Schall, REA, Subramanian, M, McHutchison, JG, Afdhal, NH, and Muir, AJ. "Serum lysyl oxidase-like-2 (sLOXL2) levels correlate with fibrosis stage in patients with nonalcoholic steatohepatitis (NASH)." October 2015.

Scholars@Duke

Henao, R, Hasanaliyeva, N, Bell, LN, Wulff, J, Perichon, R, Moylan, CA, Lu, JT, Guy, CD, Diehl, AM, and Abdelmalek, MF. "Plasma Metabolomic Profiles Predict Advanced Hepatic Fibrosis in Patients with Nonalcoholic Fatty Liver Disease." October 2015.

Scholars@Duke

Moylan, CA, Murphy, SK, Grenier, C, Abdelmalek, MF, and Diehl, AM. "DNA Methylation Profiles of Fibrosis-Associated Gene in Blood Reflects Liver Fibrosis Severity in Human Nonalcoholic Fatty Liver Disease." October 2015.

Scholars@Duke

Hasanaliyeva, N, Patel, K, Guy, CD, Gruss, HJ, Streilein, R, Hall, R, Diehl, AM, and Abdelmalek, MF. "IL-8 and MCP1 are Independently Associated with Hepatic Fibrosis in Patients with Nonalcoholic Fatty Liver Disease." October 2015.

Scholars@Duke

Sanyal, AJ, Goodman, ZD, Abdelmalek, MF, Harrison, SA, Rockey, DC, Diehl, AM, Caldwell, SH, Shiffman, ML, Myers, RP, Schall, REA, Subramanian, M, McHutchison, JG, Ratziu, V, Afdhal, NH, and Bosch, J. "Clinical and histologic correlates of the hepatic venous pressure gradient (HVPG) in patients with compensated cirrhosis due to nonalcoholic steatohepatitis (NASH)." October 2015.

Scholars@Duke

Ratziu, V, Harrison, SA, Francque, SM, Bedossa, P, Serfaty, L, Romero-Gomez, M, Cales, P, Abdelmalek, MF, Caldwell, SH, Drenth, J, Anstee, QM, Hum, DW, Hanf, R, Roudot, A, Megnien, S, Staels, B, and Sanyal, AJ. "An international, phase 2 randomized controlled trial of the dual PPAR alpha-delta agonist GFT505 in adult patients with NASH." October 2015.

Scholars@Duke

Ratziu, V, Sanyal, AJ, Loomba, R, Caldwell, SH, Ghalib, RH, Torres, DM, McCullough, AJ, Muir, AJ, Myers, RP, Schall, REA, Subramanian, M, McHutchison, JG, Bosch, J, Harrison, SA, and Abdelmalek, MF. "Characterization of insulin resistance in patients with advanced fibrosis due to nonalcoholic steatohepatitis (NASH)." October 2015.

Scholars@Duke

Loomba, R, Sanyal, AJ, Kowdley, KV, Terrault, N, Chalasani, NP, Abdelmalek, MF, McCullough, AJ, Yan, X, Shringarpure, R, Ferguson, B, Shapiro, D, and Neuschwander-Tetri, BA. "Predictors of improvement in NAFLD Activity Score to obeticholic acid: A secondary analysis of FLINT Trial." October 2015.

Scholars@Duke

Pages