Manal F. Abdelmalek, MD

Professor of Medicine
Campus mail 03119 Hosp South, Suite 03107, Room 03125, Durham, NC 27710
Phone (919) 684-3262
Email address manal.abdelmalek@duke.edu

My research interests include metabolic liver disease, particularly obesity-related liver disease and its association with complications of the insulin resistance syndrome. I am interested in studying the clinical, environmental, and genetic risk factors for nonalcoholic fatty liver disease, new therapeutic options for treatment, and evaluating the impact of NAFLD from a public health perspective.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Mayo School of Health Sciences, 1995 - 1998
  • Medical Resident, Medicine, Mayo School of Health Sciences, 1992 - 1995
  • M.D., University Missouri Kansas City, 1992

Publications

Klair, JS, Yang, JD, Abdelmalek, MF, Guy, CD, Gill, RM, Yates, KP, Unalp-Arida, A, Lavine, JE, Clark, JM, Diehl, AM, and Suzuki, A. "Risk of severe fibrosis is associated with age at menopause in nonalcoholic fatty liver disease (NAFLD)." 2014.

Scholars@Duke

Bohinc, B, Michelotti, GA, Xie, G, Pang, H, Suzuki, A, Guy, CD, Piercy, DL, Kruger, L, Swiderska-Syn, M, Machado, MV, Pereira, TA, Zavacki, AM, Abdelmalek, MF, and Diehl, AM. "Repair-related Activation of Hedgehog Signaling in Stromal Cells Promotes Intrahepatic Hypothyroidism." 2014.

Scholars@Duke

Sanyal, AJ, Abdelmalek, MF, Suzuki, A, Cummings, O, and Chojkier, M. "A Phase 2B Double-Blind Placebo Controlled Study of Two Doses of EPA-E in Patients With Nonalcoholic Steatohepatitis." HEPATOLOGY 58, no. 6 (December 2013): 1385A-1385A.

Scholars@Duke

Ishimoto, T, Lanaspa, MA, Rivard, CJ, Roncal-Jimenez, CA, Orlicky, DJ, Cicerchi, C, Mcmahan, RH, Abdelmalek, MF, Rosen, HR, Jackman, MR, Maclean, PS, Diggle, CP, Asipu, A, Inaba, S, Kosugi, T, Sato, W, Maruyama, S, Sánchez-Lozada, LG, Sautin, YY, Hill, JO, Bonthron, DT, and Johnson, RJ. "High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase." Hepatology 58, no. 5 (November 1, 2013): 1632-1643.

Full Text

Ishimoto, T, Lanaspa, MA, Rivard, CJ, Roncal-Jimenez, CA, Orlicky, DJ, Cicerchi, C, McMahan, RH, Abdelmalek, MF, Rosen, HR, Jackman, MR, MacLean, PS, Diggle, CP, Asipu, A, Inaba, S, Kosugi, T, Sato, W, Maruyama, S, Sánchez-Lozada, LG, Sautin, YY, Hill, JO, Bonthron, DT, and Johnson, RJ. "High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase." Hepatology 58, no. 5 (November 2013): 1632-1643.

PMID
23813872
Full Text

Murphy, SK, Yang, H, Moylan, CA, Pang, H, Dellinger, A, Abdelmalek, MF, Garrett, ME, Ashley-Koch, A, Suzuki, A, Tillmann, HL, Hauser, MA, and Diehl, AM. "Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease." Gastroenterology 145, no. 5 (November 2013): 1076-1087.

PMID
23916847
Full Text

Guy, CD, Suzuki, A, Abdelmalek, MF, Burchette, J, and Diehl, AM. "Hedgehog Pathway Targeted by Vitamin E Therapy in NASH." October 2013.

Scholars@Duke

Youssef, NA, Abdelmalek, MF, Binks, M, Guy, CD, Omenetti, A, Smith, AD, Diehl, AME, and Suzuki, A. "Associations of depression, anxiety and antidepressants with histological severity of nonalcoholic fatty liver disease." Liver Int 33, no. 7 (August 2013): 1062-1070.

PMID
23560860
Full Text

Swiderska-Syn, M, Suzuki, A, Guy, CD, Schwimmer, JB, Abdelmalek, MF, Lavine, JE, and Diehl, AM. "Hedgehog pathway and pediatric nonalcoholic fatty liver disease." Hepatology 57, no. 5 (May 2013): 1814-1825.

PMID
23300059
Full Text

Corbin, KD, Abdelmalek, MF, Spencer, MD, da Costa, K-A, Galanko, JA, Sha, W, Suzuki, A, Guy, CD, Cardona, DM, Torquati, A, Diehl, AM, and Zeisel, SH. "Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis." FASEB J 27, no. 4 (April 2013): 1674-1689.

PMID
23292069
Full Text

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