Manal F. Abdelmalek, MD

Professor of Medicine
Campus mail 03119 Hosp South, Suite 03107, Room 03125, Durham, NC 27710
Phone (919) 684-3262
Email address manal.abdelmalek@duke.edu

My research interests include metabolic liver disease, particularly obesity-related liver disease and its association with complications of the insulin resistance syndrome. I am interested in studying the clinical, environmental, and genetic risk factors for nonalcoholic fatty liver disease, new therapeutic options for treatment, and evaluating the impact of NAFLD from a public health perspective.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Mayo School of Health Sciences, 1995 - 1998
  • Medical Resident, Medicine, Mayo School of Health Sciences, 1992 - 1995
  • M.D., University Missouri Kansas City, 1992

Publications

Vuppalanchi, R, Siddiqui, MS, Hallinan, EK, Abdelmalek, MF, Neuschwander-Tetri, BA, Loomba, R, Kowdley, KV, Terrault, N, McCullough, AJ, Tonascia, J, Brunt, EM, Kleiner, DE, Doo, E, Chalasani, NP, and Sanyal, AJ. "Transient Elastography is Feasible with High Success Rate for Evaluation of Non-Alcoholic Fatty Liver Disease (NAFLD) in a Multicenter Setting." October 2015.

Scholars@Duke

Abdelmalek, MF, Kowdley, KV, Terrault, N, Neuschwander-Tetri, BA, Sanyal, AJ, Loomba, R, Yan, X, Shringarpure, R, Shapiro, D, and McCullough, AJ. "Effect of biopsy length on histological response assessment in NASH trials: A secondary analysis of FLINT Trial." October 2015.

Scholars@Duke

Goodman, ZD, Alaparthi, L, Monge, F, Patel, K, Loomba, R, Caldwell, SH, Lawitz, E, Harrison, SA, Shiffman, ML, Abdelmalek, MF, Myers, RP, Schall, REA, Subramanian, M, McHutchison, JG, Ratziu, V, Sanyal, AJ, and Afdhal, NH. "Correlations between hepatic morphometric collagen content, histologic fibrosis staging, and serum markers in patients with advanced fibrosis due to nonalcoholic steatohepatitis (NASH)." October 2015.

Scholars@Duke

Harrison, SA, Sanyal, AJ, Francque, SM, Bedossa, P, Serfaty, L, Romero-Gomez, M, Cales, P, Abdelmalek, MF, Caldwell, SH, Drenth, J, Anstee, QM, Hum, DW, Hanf, R, Roudot, A, Megnien, S, Staels, B, and Ratziu, V. "Beneficial effects of the dual PPAR alpha-delta agonist, GFT505, on hepatic and cardiometabolic markers in adult NASH patients." October 2015.

Scholars@Duke

Chalasani, NP, Loomba, R, Terrault, N, McCullough, AJ, Abdelmalek, MF, Kowdley, KV, Neuschwander-Tetri, BA, Hazra, S, Yan, X, Shringarpure, R, MacConell, L, and Sanyal, AJ. "Longitudinal changes in FIB-4 and improvement in fibrosis stage with obeticholic acid: A secondary analysis of FLINT Trial." October 2015.

Scholars@Duke

Abdelmalek, MF, and Day, C. "Sugar sweetened beverages and fatty liver disease: Rising concern and call to action." Journal of hepatology 63, no. 2 (August 2015): 306-308.

PMID
26036988
Full Text

Deng, Y, Palmeri, ML, Rouze, NC, Rosenzweig, SJ, Abdelmalek, MF, and Nightingale, KR. "Analyzing the Impact of Increasing Mechanical Index and Energy Deposition on Shear Wave Speed Reconstruction in Human Liver." Ultrasound in medicine & biology 41, no. 7 (July 2015): 1948-1957.

PMID
25896024
Full Text

Guy, C, Suzuki, A, Abdelmalek, M, Burchette, J, and Diehl, AM. "Reply." Hepatology 61, no. 5 (May 2015): 1770-1771.

Full Text

Zhu, R, Baker, SS, Moylan, CA, Abdelmalek, MF, Guy, CD, Zamboni, F, Wu, D, Lin, W, Liu, W, Baker, RD, Govindarajan, S, Cao, Z, Farci, P, Diehl, AM, and Zhu, L. "Systematic Analysis of NAFLD Transcriptome Revealed Elevated Expression of Alcohol Metabolizing Genes in Mild and Severe NAFLD Livers." April 2015.

Scholars@Duke

Neuschwander-Tetri, BA, Loomba, R, Sanyal, AJ, Lavine, JE, Van Natta, ML, Abdelmalek, MF, Chalasani, N, Dasarathy, S, Diehl, AM, Hameed, B, Kowdley, KV, McCullough, A, Terrault, N, Clark, JM, Tonascia, J, Brunt, EM, Kleiner, DE, Doo, E, and NASH Clinical Research Network, . "Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial." Lancet (London, England) 385, no. 9972 (March 2015): 956-965.

PMID
25468160
Full Text

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