Manal F. Abdelmalek, MD

Professor of Medicine
Campus mail 03119 Hosp South, Suite 03107, Room 03125, Durham, NC 27710
Phone (919) 684-3262
Email address manal.abdelmalek@duke.edu

My research interests include metabolic liver disease, particularly obesity-related liver disease and its association with complications of the insulin resistance syndrome. I am interested in studying the clinical, environmental, and genetic risk factors for nonalcoholic fatty liver disease, new therapeutic options for treatment, and evaluating the impact of NAFLD from a public health perspective.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Mayo School of Health Sciences, 1995 - 1998
  • Medical Resident, Medicine, Mayo School of Health Sciences, 1992 - 1995
  • M.D., University Missouri Kansas City, 1992

Publications

Guy, CD, Suzuki, A, Burchette, JL, Brunt, EM, Abdelmalek, MF, Cardona, D, McCall, SJ, Ünalp, A, Belt, P, Ferrell, LD, Diehl, AM, and Nonalcoholic Steatohepatitis Clinical Research Network, . "Costaining for keratins 8/18 plus ubiquitin improves detection of hepatocyte injury in nonalcoholic fatty liver disease." Hum Pathol 43, no. 6 (June 2012): 790-800.

PMID
22036053
Full Text

Guy, CD, Suzuki, A, Zdanowicz, M, Abdelmalek, MF, Burchette, J, Unalp, A, Diehl, AM, and NASH CRN, . "Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease." Hepatology 55, no. 6 (June 2012): 1711-1721.

PMID
22213086
Full Text

Moylan, CA, Yang, H, Pang, H, Dellinger, A, Suzuki, A, Tillmann, HL, Guy, CD, Ashley-Koch, AE, Garrett, ME, Abdelmalek, MF, Hauser, MA, Murphy, SK, and Diehl, AM. "Epigenetic Regulation of Gene Expression in NAFLD." May 2012.

Scholars@Duke

Corbin, KD, Spencer, MD, da Costa, K-A, Sha, W, Abdelmalek, MF, Pan, Y, Suzuki, A, Guy, CD, Cardona, DM, Torquati, A, Diehl, AM, and Zeisel, SH. "Genotype-based hierarchical clustering reveals a panel of polymorphisms in one carbon metabolism that are associated with obesity." April 2012.

Scholars@Duke

Abdelmalek, MF, Humar, A, Stickel, F, Andreone, P, Pascher, A, Barroso, E, Neff, GW, Ranjan, D, Toselli, LT, Gane, EJ, Scarola, J, Alberts, RG, Maller, ES, Lo, C-M, and Sirolimus Liver Conversion Trial Study Group, . "Sirolimus conversion regimen versus continued calcineurin inhibitors in liver allograft recipients: a randomized trial." Am J Transplant 12, no. 3 (March 2012): 694-705.

PMID
22233522
Full Text

Ratziu, V, Sheikh, MY, Sanyal, AJ, Lim, JK, Conjeevaram, H, Chalasani, N, Abdelmalek, M, Bakken, A, Renou, C, Palmer, M, Levine, RA, Bhandari, BR, Cornpropst, M, Liang, W, King, B, Mondou, E, Rousseau, FS, Mchutchison, J, and Chojkier, M. "A phase 2, randomized, double-blind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitis." Hepatology 55, no. 2 (2012): 419-428.

PMID
22006541
Full Text

Nelson, JE, Brunt, EM, Kowdley, KV, Abrams, SH, Fairly, LA, McCullough, AJ, Brandt, P, Bringman, D, Dasarathy, S, Dasarathy, J, Hawkins, C, Liu, Y-C, Rogers, N, Stager, M, Whitwell, J, McCullough, AJ, Dasarathy, S, Pagadala, M, Sargent, R, Yerian, L, Zein, C, Merriman, R, Nguyen, A, Mohan, P, Nair, K, DeVore, S, Kohli, R, Lake, K, Xanthakos, S, Cosme, Y, Lavine, JE, Mencin, A, Ovchinsky, N, Abdelmalek, MF, Buie, S, Diehl, AM, Gottfried, M, Guy, C, Hanna, M, Kigongo, C, Killenberg, P, and Kwan, S et al. "Lower serum hepcidin and greater parenchymal iron in nonalcoholic fatty liver disease patients with C282Y HFE mutations." Hepatology 56, no. 5 (2012): 1730-1740.

PMID
22611049
Full Text

Palmeri, ML, Abdelmalek, MF, and Nightingale, KR. "Reply to: The use of acoustic radiation force-based shear stiffness in non-alcoholic fatty liver disease." Journal of Hepatology 56, no. 4 (2012): 996--.

Full Text

Syn, W-K, Agboola, KM, Swiderska, M, Michelotti, GA, Liaskou, E, Pang, H, Xie, G, Philips, G, Chan, IS, Karaca, GF, Pereira, TDA, Chen, Y, Mi, Z, Kuo, PC, Choi, SS, Guy, CD, Abdelmalek, MF, and Diehl, AM. "NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease." Gut (2012).

Full Text

Shah, KK, Suzuki, A, Schwimmer, JB, Unalp, A, Guy, CD, Molleston, JP, Whitington, PF, Johnson, R, Diehl, AM, and Abdelmalek, MF. "DOSE DEPENDENT ASSOCIATION OF FRUCTOSE CONSUMPTION WITH HYPERURICEMIA AND INSULIN RESISTANCE IN CHILDREN WITH NAFLD." October 2011.

Scholars@Duke

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