Manal F. Abdelmalek, MD

Professor of Medicine
Campus mail 03119 Hosp South, Suite 03107, Room 03125, Durham, NC 27710
Phone (919) 684-3262
Email address manal.abdelmalek@duke.edu

My research interests include metabolic liver disease, particularly obesity-related liver disease and its association with complications of the insulin resistance syndrome. I am interested in studying the clinical, environmental, and genetic risk factors for nonalcoholic fatty liver disease, new therapeutic options for treatment, and evaluating the impact of NAFLD from a public health perspective.

In Their Words

Education and Training

  • Fellow in Gastroenterology, Medicine, Mayo School of Health Sciences, 1995 - 1998
  • Medical Resident, Medicine, Mayo School of Health Sciences, 1992 - 1995
  • M.D., University Missouri Kansas City, 1992

Publications

Palmeri, ML, Wang, MH, Rouze, NC, Abdelmalek, MF, Guy, CD, Moser, B, Diehl, AM, and Nightingale, KR. "Noninvasive evaluation of hepatic fibrosis using acoustic radiation force-based shear stiffness in patients with nonalcoholic fatty liver disease." J Hepatol 55, no. 3 (September 2011): 666-672.

PMID
21256907
Full Text

Rangwala, F, Guy, CD, Lu, J, Suzuki, A, Burchette, JL, Abdelmalek, MF, Chen, W, and Diehl, AM. "Increased production of sonic hedgehog by ballooned hepatocytes." J Pathol 224, no. 3 (July 2011): 401-410.

PMID
21547909
Full Text

Moylan, CA, Dellinger, A, Pang, H, Suzuki, A, Tillmann, HL, Hampton, D, Chen, Y, Choi, SS, Hauser, MA, Abdelmalek, MF, and Diehl, AM. "Modest Alcohol Consumption Attenuates Expression of Fibrosis-Associated Genes in Patients With Non-Alcoholic Fatty Liver Disease (NAFLD)." May 2011.

Scholars@Duke

Zdanowicz, M, Suzuki, A, Guy, CD, Schwimmer, J, Abdelmalek, MF, Lavine, JE, and Diehl, AM. "Hedgehog Pathway Activation is Associated With Advanced Fibrosis in Pediatric NAFLD." May 2011.

Scholars@Duke

Corbin, KD, da Costa, K-A, Sha, W, Abdelmalek, MF, Diehl, AM, and Zeisel, SH. "Single nucleotide polymorphisms affecting phosphatidylcholine transport are associated with obesity." April 2011.

Scholars@Duke

Syn, W-K, Choi, SS, Liaskou, E, Karaca, GF, Agboola, KM, Oo, YH, Mi, Z, Pereira, TA, Zdanowicz, M, Malladi, P, Chen, Y, Moylan, C, Jung, Y, Bhattacharya, SD, Teaberry, V, Omenetti, A, Abdelmalek, MF, Guy, CD, Adams, DH, Kuo, PC, Michelotti, GA, Whitington, PF, and Diehl, AM. "Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis." Hepatology 53, no. 1 (January 2011): 106-115.

PMID
20967826
Full Text

Suzuki, A, Abdelmalek, MF, Unalp-Arida, A, Yates, K, Sanyal, A, Guy, C, and Diehl, AM. "Regional anthropometric measures and hepatic fibrosis in patients with nonalcoholic Fatty liver disease." Clin Gastroenterol Hepatol 8, no. 12 (December 2010): 1062-1069.

PMID
20728571
Full Text

Abdelmalek, MF, Suzuki, A, Schmidt, S, Rimmler, J, Unalp, A, Guy, CD, Johnson, R, Hauser, MA, and Diehl, AM. "FRUCTOKINASE POLYMORPHISMS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE ARE ASSOCIATED WITH DECREASED URIC ACID AND THE PRESENCE OF HEPATIC FIBROSIS." October 2010.

Scholars@Duke

Moylan, CA, Choi, SS, Dellinger, A, Pang, H, Abdelmalek, MF, Hampton, D, Chen, Y, Omenetti, A, Suzuki, A, Tillmann, HL, Acharya, CR, Potti, A, Hauser, MA, and Diehl, AM. "CONSERVED GENE EXPRESSION PATTERNS IN MYOFIBROBLASTIC MURINE AND HUMAN HEPATIC STELLATE CELLS AND NAFLD PATIENTS WITH LIVER FIBROSIS COMPATIBLE WITH EPITHELIAL-TO-MESENCHYMAL LIKE TRANSITION." October 2010.

Scholars@Duke

Moylan, CA, Abdelmalek, MF, Pang, H, Dellinger, A, Choi, SS, Omenetti, A, Chen, Y, Hampton, D, Syn, W-K, Suzuki, A, Tillmann, HL, Acharya, CR, Potti, A, Hauser, MA, and Diehl, AM. "SIGNALS FROM THE FIBROTIC LIVER IN PATIENTS WITH NAFLD MAY PROMOTE DIABETES AND OBESITY." October 2010.

Scholars@Duke

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