Marc G. Caron, PhD

Professor of Cell Biology
James B. Duke Professor of Cell Biology
Vice Chair for Science and Research in the Department of Cell Biology
Professor in Neurobiology
Professor in Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Affiliate of the Regeneration Next Initiative
Campus mail CARL Building Room 487, Durham, NC 27710
Phone (919) 684-5433
Email address marc.caron@duke.edu

Studies of the mechanisms of action and regulation of hormones and neurotransmitters at the cellular and molecular levels constitute the main goals our of research activities. G protein-coupled receptors (GPCR) mediate the actions of signaling molecules from unicellular organisms to man. We have used adrenergic and dopamine receptors to characterize the structure/function and regulation mechanisms of these prototypes of G protein-coupled receptors. Another approach has been to characterize the nature of neurotransmitter transporters for dopamine, serotonin and other neurotransmitters in an attempt to understand their function in normal and pathological neurotransmission. Another goal of our laboratory is to define the genes and pathways involved in the reinforcing properties of drugs of abuse using both forward and reverse genetic approaches. Our laboratory uses biochemical, molecular biology and gene targeting approaches to examine these questions.

Education and Training

  • Ph.D., University of Miami, 1973

Publications

Rose, SJ, Pack, TF, Peterson, SM, Payne, K, Borrelli, E, and Caron, MG. "Engineered D2R Variants Reveal the Balanced and Biased Contributions of G-Protein and β-Arrestin to Dopamine-Dependent Functions." Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 43, no. 5 (April 2018): 1164-1173.

PMID
29068002
Full Text

Beraldo, FH, Ostapchenko, VG, Xu, JZ, Di Guglielmo, GM, Fan, J, Nicholls, PJ, Caron, MG, Prado, VF, and Prado, MAM. "Mechanisms of neuroprotection against ischemic insult by stress-inducible phosphoprotein-1/prion protein complex." Journal of Neurochemistry 145, no. 1 (April 2018): 68-79.

PMID
29265373
Full Text

Pack, TF, Orlen, MI, Ray, C, Peterson, SM, and Caron, MG. "The dopamine D2 receptor can directly recruit and activate GRK2 without G protein activation." The Journal of biological chemistry 293, no. 16 (April 2018): 6161-6171.

PMID
29487132
Full Text

Sachs, BD, Tran, HL, Folse, E, and Caron, MG. "Brain-region-specific Molecular Responses to Maternal Separation and Social Defeat Stress in Mice." Neuroscience 373 (March 2018): 122-136.

PMID
29341883
Full Text

Hultman, R, Ulrich, K, Sachs, BD, Blount, C, Carlson, DE, Ndubuizu, N, Bagot, RC, Parise, EM, Vu, M-AT, Gallagher, NM, Wang, J, Silva, AJ, Deisseroth, K, Mague, SD, Caron, MG, Nestler, EJ, Carin, L, and Dzirasa, K. "Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability." Cell 173, no. 1 (March 2018): 166-180.e14.

PMID
29502969
Full Text

Toth, K, Slosky, LM, Pack, TF, Urs, NM, Boone, P, Mao, L, Abraham, D, Caron, MG, and Barak, LS. "Ghrelin receptor antagonism of hyperlocomotion in cocaine-sensitized mice requires βarrestin-2." Synapse (New York, N.Y.) 72, no. 1 (January 2018).

PMID
28941296
Full Text

Zhu, L, Rossi, M, Cui, Y, Lee, RJ, Sakamoto, W, Perry, NA, Urs, NM, Caron, MG, Gurevich, VV, Godlewski, G, Kunos, G, Chen, M, Chen, W, and Wess, J. "Hepatic β-arrestin 2 is essential for maintaining euglycemia." The Journal of Clinical Investigation 127, no. 8 (August 2017): 2941-2945.

PMID
28650340
Full Text

Fakhouri, L, Cook, CD, Al-Huniti, MH, Console-Bram, LM, Hurst, DP, Spano, MBS, Nasrallah, DJ, Caron, MG, Barak, LS, Reggio, PH, Abood, ME, and Croatt, MP. "Design, synthesis and biological evaluation of GPR55 agonists." Bioorganic & Medicinal Chemistry 25, no. 16 (August 2017): 4355-4367.

PMID
28673732
Full Text

Le Gonidec, S, Chaves-Almagro, C, Bai, Y, Kang, HJ, Smith, A, Wanecq, E, Huang, X-P, Prats, H, Knibiehler, B, Roth, BL, Barak, LS, Caron, MG, Valet, P, Audigier, Y, and Masri, B. "Protamine is an antagonist of apelin receptor, and its activity is reversed by heparin." Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 31, no. 6 (June 2017): 2507-2519.

PMID
28242772
Full Text

Snyder, JC, Rochelle, LK, Ray, C, Pack, TF, Bock, CB, Lubkov, V, Lyerly, HK, Waggoner, AS, Barak, LS, and Caron, MG. "Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness." The Journal of biological chemistry 292, no. 17 (April 2017): 7208-7222.

PMID
28275053
Full Text

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