Marc G. Caron, PhD

Professor of Cell Biology
James B. Duke Professor of Cell Biology
Vice Chair for Science and Research in the Department of Cell Biology
Professor in Neurobiology
Professor in Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Affiliate of the Regeneration Next Initiative
Campus mail CARL Building Room 487, Durham, NC 27710
Phone (919) 684-5433
Email address marc.caron@duke.edu

Studies of the mechanisms of action and regulation of hormones and neurotransmitters at the cellular and molecular levels constitute the main goals our of research activities. G protein-coupled receptors (GPCR) mediate the actions of signaling molecules from unicellular organisms to man. We have used adrenergic and dopamine receptors to characterize the structure/function and regulation mechanisms of these prototypes of G protein-coupled receptors. Another approach has been to characterize the nature of neurotransmitter transporters for dopamine, serotonin and other neurotransmitters in an attempt to understand their function in normal and pathological neurotransmission. Another goal of our laboratory is to define the genes and pathways involved in the reinforcing properties of drugs of abuse using both forward and reverse genetic approaches. Our laboratory uses biochemical, molecular biology and gene targeting approaches to examine these questions.

Education and Training

  • Ph.D., University of Miami, 1973

Publications

Toth, K, Slosky, LM, Pack, TF, Urs, NM, Boone, P, Mao, L, Abraham, D, Caron, MG, and Barak, LS. "Ghrelin receptor antagonism of hyperlocomotion in cocaine-sensitized mice requires βarrestin-2. (Accepted)" Synapse (New York, N.Y.) 72, no. 1 (January 2018).

PMID
28941296
Full Text

Zhu, L, Rossi, M, Cui, Y, Lee, RJ, Sakamoto, W, Perry, NA, Urs, NM, Caron, MG, Gurevich, VV, Godlewski, G, Kunos, G, Chen, M, Chen, W, and Wess, J. "Hepatic β-arrestin 2 is essential for maintaining euglycemia." Journal of Clinical Investigation 127, no. 8 (August 2017): 2941-2945.

PMID
28650340
Full Text

Fakhouri, L, Cook, CD, Al-Huniti, MH, Console-Bram, LM, Hurst, DP, Spano, MBS, Nasrallah, DJ, Caron, MG, Barak, LS, Reggio, PH, Abood, ME, and Croatt, MP. "Design, synthesis and biological evaluation of GPR55 agonists." Bioorganic & medicinal chemistry 25, no. 16 (August 2017): 4355-4367.

PMID
28673732
Full Text

Le Gonidec, S, Chaves-Almagro, C, Bai, Y, Kang, HJ, Smith, A, Wanecq, E, Huang, X-P, Prats, H, Knibiehler, B, Roth, BL, Barak, LS, Caron, MG, Valet, P, Audigier, Y, and Masri, B. "Protamine is an antagonist of apelin receptor, and its activity is reversed by heparin." FASEB journal : official publication of the Federation of American Societies for Experimental Biology 31, no. 6 (June 2017): 2507-2519.

PMID
28242772
Full Text

Snyder, JC, Rochelle, LK, Ray, C, Pack, TF, Bock, CB, Lubkov, V, Lyerly, HK, Waggoner, AS, Barak, LS, and Caron, MG. "Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness." The Journal of biological chemistry 292, no. 17 (April 2017): 7208-7222.

PMID
28275053
Full Text

Ray, C, Soderblom, EJ, Bai, Y, Carroll, FI, Caron, MG, and Barak, LS. "Probing the Allosteric Role of the α5 Subunit of α3β4α5 Nicotinic Acetylcholine Receptors by Functionally Selective Modulators and Ligands." ACS chemical biology 12, no. 3 (March 2017): 702-714.

PMID
28045487
Full Text

Zhu, L, Almaça, J, Dadi, PK, Hong, H, Sakamoto, W, Rossi, M, Lee, RJ, Vierra, NC, Lu, H, Cui, Y, McMillin, SM, Perry, NA, Gurevich, VV, Lee, A, Kuo, B, Leapman, RD, Matschinsky, FM, Doliba, NM, Urs, NM, Caron, MG, Jacobson, DA, Caicedo, A, and Wess, J. "β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions." Nature communications 8 (February 2017): 14295-.

PMID
28145434
Full Text

Urs, NM, Peterson, SM, and Caron, MG. "New Concepts in Dopamine D2 Receptor Biased Signaling and Implications for Schizophrenia Therapy." Biological psychiatry 81, no. 1 (January 2017): 78-85. (Review)

PMID
27832841
Full Text

Urs, NM, Gee, SM, Pack, TF, McCorvy, JD, Evron, T, Snyder, JC, Yang, X, Rodriguiz, RM, Borrelli, E, Wetsel, WC, Jin, J, Roth, BL, O'Donnell, P, and Caron, MG. "Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties." Proceedings of the National Academy of Sciences of the United States of America 113, no. 50 (December 2016): E8178-E8186.

PMID
27911814
Full Text

Jacobsen, JPR, Krystal, AD, Krishnan, KRR, and Caron, MG. "Adjunctive 5-Hydroxytryptophan Slow-Release for Treatment-Resistant Depression: Clinical and Preclinical Rationale." Trends in pharmacological sciences 37, no. 11 (November 2016): 933-944. (Review)

PMID
27692695
Full Text

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