Marilyn Jo Telen, MD

Professor of Medicine
Wellcome Clinical Distinguished Professor of Medicine in Honor of R. Wayne Rundles, M.D.
Associate Professor of Pathology
Member of the Duke Cancer Institute
Affiliate, Duke Global Health Institute
Campus mail 333 Med Sci Res Bldg, Durham, NC 27710
Phone (919) 684-5378
Email address marilyn.telen@duke.edu

Dr. Telen is recognized as an expert in the biochemistry and molecular genetics of blood group antigens and the pathophysiological mechanisms of vaso-occlusion in sickle cell disease. She is the Director of the Duke Comprehensive Sickle Cell Center.

Dr. Telen's laboratory focuses on structure/function analysis of membrane proteins expressed by erythroid cells, as well as the role of these proteins in non-erythroid cells. Proteins are also studied in transfectant systems, and research focuses especially on adhesion receptors. The goals of this work are (1) to understand the mechanism and role of red cell adhesion to leukocytes and endothelium in sickle cell disease; (2) to understand the signaling mechanisms leading to activation (and inactivation) of red cell adhesion molecules; (3) to understand the molecular basis of blood group antigen expression, and (4) to understand the interactions of erythroid membrane proteins with other cells and with extracellular matrix..

Recent investigations have focused on the role of signaling pathways in the upregulation of sickle red cell adhesion. Present studies include (1) investigation of beta-adrenergic signaling pathway responsible for activation of B-CAM/LU and LW adhesion receptors; (2) understanding how nitric oxide and ATP downregulate sickle red cell adhesion; (3) studying the effect of these processes in animal models.

Dr. Telen is also involved in a large multicenter study looking for genetic polymorphisms that affect clinical outcomes in sickle cell disease, as well as a multi-center study investigating the mechanisms and treatment of pulmonary hypertension in sickle cell disease.

Key Words:

Adhesion molecules
Erythrocyte membrane
Sickle cell disease
Transfusion medicine
Immunohematology
CD44
B-CAM/LU
Genetic polymorphisms

Education and Training

  • Fellowship, Hematology/ Oncology, Duke University School of Medicine, 1980 - 1983
  • Resident, Medicine, State University of New York - Buffalo, 1977 - 1980
  • Intern, Medicine, State University of New York - Buffalo, 1977 - 1978
  • M.D., New York University, 1977

Publications

Zekavat, Seyedeh M., Sanni Ruotsalainen, Robert E. Handsaker, Maris Alver, Jonathan Bloom, Timothy Poterba, Cotton Seed, et al. “Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.” Nat Commun 9, no. 1 (August 23, 2018): 3493. https://doi.org/10.1038/s41467-018-05975-y.

PMID
30140049
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Natarajan, Pradeep, Gina M. Peloso, Seyedeh Maryam Zekavat, May Montasser, Andrea Ganna, Mark Chaffin, Amit V. Khera, et al. “Deep-coverage whole genome sequences and blood lipids among 16,324 individuals.” Nat Commun 9, no. 1 (August 23, 2018): 3391. https://doi.org/10.1038/s41467-018-05747-8.

PMID
30140000
Full Text

Zekavat, Seyedeh M., Sanni Ruotsalainen, Robert E. Handsaker, Maris Alver, Jonathan Bloom, Timothy Poterba, Cotton Seed, et al. “Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.” Nat Commun 9, no. 1 (July 4, 2018): 2606. https://doi.org/10.1038/s41467-018-04668-w.

PMID
29973585
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Adam, Soheir S., Charlene M. Flahiff, Shital Kamble, Marilyn J. Telen, Shelby D. Reed, and Laura M. De Castro. “Depression, quality of life, and medical resource utilization in sickle cell disease.” Blood Adv 1, no. 23 (October 24, 2017): 1983–92. https://doi.org/10.1182/bloodadvances.2017006940.

PMID
29296845
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Jacob, Seethal A., Enrico M. Novelli, Jeffrey S. Isenberg, Melanie E. Garrett, Yanxia Chu, Karen Soldano, Kenneth I. Ataga, et al. “Thrombospondin-1 gene polymorphism is associated with estimated pulmonary artery pressure in patients with sickle cell anemia.” Am J Hematol 92, no. 3 (March 2017): E31–34. https://doi.org/10.1002/ajh.24635.

PMID
28033687
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Alther, R. A., P. Arndt, D. Bailey, C. Barron, N. Benitez, J. S. Boyd, B. J. Bryant, et al. “Communications: To contributors to the 2017 issues.” Immunohematology 33, no. 4 (January 1, 2017): 173–172.

Scholars@Duke

Anderson, Blair R., Melanie E. Garrett, Karen L. Soldano, Eugene P. Orringer, James R. Eckman, Ludmila Francescatto, Erica E. Davis, et al. “GWAS Meta-Analysis of Glomerular Filtration Rate in Three Cohorts of Sickle Cell Disease Patients and In Vivo Functional Analysis Reveals Potential Nephropathy Candidate Genes.” In Blood, 128:269–269. American Society of Hematology, 2016. https://doi.org/10.1182/blood.v128.22.269.269.

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Narine, Kalindi Yajnik, Jennifer Minjia Chang, Jude Jonassaint, Marilyn J. Telen, and Nirmish Shah. “Use of Mobile Technology to Monitor Pain and Reduce Outpatient, Emergency Department (ED), and Hospital Visits for Sickle Cell Pain Crisis.” In Blood, 128:2390–2390. American Society of Hematology, 2016. https://doi.org/10.1182/blood.v128.22.2390.2390.

Full Text

Chang, Jennifer Minjia, Martha Delahunty, Milena Batchvarova, Karen L. Soldano, J Michael Cook, and Marilyn J. Telen. “Effect of FXIII Polymorphism on Formation of Heterocellular Aggregates in SCD.” In Blood, 128:3648–3648. American Society of Hematology, 2016. https://doi.org/10.1182/blood.v128.22.3648.3648.

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