Marilyn Jo Telen, MD

Professor of Medicine
Wellcome Clinical Distinguished Professor of Medicine in Honor of R. Wayne Rundles, M.D.
Associate Professor of Pathology
Member of the Duke Cancer Institute
Affiliate, Duke Global Health Institute
Campus mail 333 Med Sci Res Bldg, Durham, NC 27710
Phone (919) 684-5378
Email address marilyn.telen@duke.edu

Dr. Telen is recognized as an expert in the biochemistry and molecular genetics of blood group antigens and the pathophysiological mechanisms of vaso-occlusion in sickle cell disease. She is the Director of the Duke Comprehensive Sickle Cell Center.

Dr. Telen's laboratory focuses on structure/function analysis of membrane proteins expressed by erythroid cells, as well as the role of these proteins in non-erythroid cells. Proteins are also studied in transfectant systems, and research focuses especially on adhesion receptors. The goals of this work are (1) to understand the mechanism and role of red cell adhesion to leukocytes and endothelium in sickle cell disease; (2) to understand the signaling mechanisms leading to activation (and inactivation) of red cell adhesion molecules; (3) to understand the molecular basis of blood group antigen expression, and (4) to understand the interactions of erythroid membrane proteins with other cells and with extracellular matrix..

Recent investigations have focused on the role of signaling pathways in the upregulation of sickle red cell adhesion. Present studies include (1) investigation of beta-adrenergic signaling pathway responsible for activation of B-CAM/LU and LW adhesion receptors; (2) understanding how nitric oxide and ATP downregulate sickle red cell adhesion; (3) studying the effect of these processes in animal models.

Dr. Telen is also involved in a large multicenter study looking for genetic polymorphisms that affect clinical outcomes in sickle cell disease, as well as a multi-center study investigating the mechanisms and treatment of pulmonary hypertension in sickle cell disease.

Key Words:

Adhesion molecules
Erythrocyte membrane
Sickle cell disease
Transfusion medicine
Immunohematology
CD44
B-CAM/LU
Genetic polymorphisms

Education and Training

  • Fellowship, Hematology/ Oncology, Duke University School of Medicine, 1980 - 1983
  • Resident, Medicine, State University of New York - Buffalo, 1977 - 1980
  • Intern, Medicine, State University of New York - Buffalo, 1977 - 1978
  • M.D., New York University, 1977

Publications

Telen, Marilyn J., Araba Afenyi-Annan, Melanie E. Garrett, Martha R. Combs, Eugene P. Orringer, and Allison E. Ashley-Koch. “Alloimmunization in sickle cell disease: changing antibody specificities and association with chronic pain and decreased survival.” Transfusion 55, no. 6 Pt 2 (June 2015): 1378–87. https://doi.org/10.1111/trf.12940.

PMID
25444611
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Telen, Marilyn J., Ted Wun, Timothy L. McCavit, Laura M. De Castro, Lakshmanan Krishnamurti, Sophie Lanzkron, Lewis L. Hsu, et al. “Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use.” Blood 125, no. 17 (April 23, 2015): 2656–64. https://doi.org/10.1182/blood-2014-06-583351.

PMID
25733584
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Elmariah, Hany, Melanie E. Garrett, Karen L. Soldano, Kenneth I. Ataga, James R. Eckman, Marilyn J. Telen, and Allison E. Ashley-Koch. “Genes Associated with Survival in Adult Sickle Cell Disease.” In Blood, Vol. 124. AMER SOC HEMATOLOGY, 2014.

Scholars@Duke

Anderson, Blair R., Erica E. Davis, Marilyn J. Telen, and Allison E. Ashley-Koch. “Evidence for a Dominant Negative Effect Conferred By the APOL1 G2 Sickle Cell Nephropathy Risk Allele in an in Vivo Model.” In Blood, Vol. 124. AMER SOC HEMATOLOGY, 2014.

Scholars@Duke

Garrett, Melanie E., Karen L. Soldano, Blair R. Anderson, Eugene P. Orringer, James R. Eckman, Marilyn J. Telen, and Allison E. Ashley-Koch. “Genome-Wide Association Study of Glomerular Filtration Rate in a Cohort of Sickle Cell Disease Patients.” In Blood, Vol. 124. AMER SOC HEMATOLOGY, 2014.

Scholars@Duke

Milton, Jacqueline N., Allison E. Ashley-Koch, Melanie E. Garrett, Karen L. Soldano, Eugene P. Orringer, Paola Sebastiani, Daniel A. Dworkis, Karen Quillen, Martin H. Steinberg, and Marilyn J. Telen. “Genes Associated with Alloimmunization to Blood Group Antigens in Sickle Cell Disease.” In Blood, Vol. 124. AMER SOC HEMATOLOGY, 2014.

Scholars@Duke

Doss, Jennifer, Jude Jonassaint, Nirmish Shah, Marilyn J. Telen, and Jen-Tsan A. Chi. “Effects of Sulforaphane Obtained from Broccoli Sprout Homogenate in Patients with Sickle Cell Disease (SCD).” In Blood, Vol. 124. AMER SOC HEMATOLOGY, 2014.

Scholars@Duke

Wun, Ted, Marilyn J. Telen, Lakshmanan Krishnamurti, Timothy L. McCavit, Laura M. DeCastro, Henry Flanner, Frans A. Kuypers, et al. “Pan-Selectin Antagonist Rivipansel (GMI-1070) Reduces Soluble E-Selectin Levels While Improving Clinical Outcomes in SCD Vaso-Occlusive Crisis.” In Blood, 124:2704–2704. American Society of Hematology, 2014. https://doi.org/10.1182/blood.v124.21.2704.2704.

Full Text

Wun, T., L. Styles, L. DeCastro, M. J. Telen, and F. Kuypers. “Erratum: Phase 1 study of the E-selectin inhibitor GMI 1070 in patients with sickle cell anemia (PLoS ONE (2014) 9, 7 (e101301) DOI:10.1371/journal.pone.0101301).” Plos One 9, no. 10 (October 17, 2014). https://doi.org/10.1371/journal.pone.0111690.

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