Mark Neil Feinglos, MD

Professor of Medicine
Associate Professor of Psychiatry and Behavioral Sciences
Associate Professor of Pathology
Campus mail 270 Baker House, Durham, NC 27710
Phone (919) 684-4005
Email address mark.feinglos@duke.edu

I am interested in the etiology and treatment of type 2 diabetes mellitus. For many years, we have studied the role of the autonomic nervous system in the pathophysiology of type 2 diabetes in humans and a murine model. We have also studied the mechanism of action of dietary therapy and a variety of pharmacological agents in the treatment of type 2 diabetes.

Dr. Richard Surwit of the Department of Psychiatry and Behavioral Sciences and I are conducting a variety of human studies on the relationship of stress hormones and various food additives on the development and expression of type 2 diabetes. I am also engaged in a number of multicenter studies of the effect of various treatment plans on cardiovascular outcomes in type 2 diabetes patients. In addtion, my group continues to evaluate new treatment modalities for patients with type 2 diabetes, including new types of insulin, GLP-1 analogs, new classes of oral agents, and combinations of drugs.

I am frequently consulted by industry to evaluate new therapeutic modalities. I most frequently peer review scientific articles concerning the treatment of type 2 diabetes.

Key words: diabetes mellitus, stress, sulfonylureas, oral hypoglycemics, insulin, murine diabetes, diabetic diet

Education and Training

  • M.D., McGill University (Canada), 1973

Publications

Burt, T, MacLeod, D, Lee, K, Santoro, A, DeMasi, DK, Hawk, T, Feinglos, M, Rowland, M, and Noveck, RJ. "Intra-Target Microdosing - A Novel Drug Development Approach: Proof of Concept, Safety, and Feasibility Study in Humans." Clinical and translational science 10, no. 5 (September 2017): 351-359.

PMID
28689370
Full Text

Bress, AP, King, JB, Kreider, KE, Beddhu, S, Simmons, DL, Cheung, AK, Zhang, Y, Doumas, M, Nord, J, Sweeney, ME, Taylor, AA, Herring, C, Kostis, WJ, Powell, J, Rastogi, A, Roumie, CL, Wiggers, A, Williams, JS, Yunis, R, Zias, A, Evans, GW, Greene, T, Rocco, MV, Cushman, WC, Reboussin, DM, Feinglos, MN, Papademetriou, V, and SPRINT Research Group, . "Effect of Intensive Versus Standard Blood Pressure Treatment According to Baseline Prediabetes Status: A Post Hoc Analysis of a Randomized Trial." Diabetes care (August 9, 2017).

PMID
28793997
Full Text

Ikeno, F, Brooks, MM, Nakagawa, K, Kim, M-K, Kaneda, H, Mitsutake, Y, Vlachos, HA, Schwartz, L, Frye, RL, Kelsey, SF, Waseda, K, Hlatky, MA, and BARI-2D Study Group, . "SYNTAX Score and Long-Term Outcomes: The BARI-2D Trial." Journal of the American College of Cardiology 69, no. 4 (January 2017): 395-403.

PMID
28126156
Full Text

Luginbuhl, KM, Schaal, JL, Umstead, B, Mastria, EM, Li, X, Banskota, S, Arnold, S, Feinglos, M, D'Alessio, D, and Chilkoti, A. "One-week glucose control via zero-order release kinetics from an injectable depot of glucagon-like peptide-1 fused to a thermosensitive biopolymer." Nature biomedical engineering 1 (January 2017).

PMID
29062587
Full Text

Flynn, S, Barton, IF, and Feinglos, M. "Munakataite, Pb2Cu2(Se4+O3)(SO4)(OH)4, and Other Selenium Minerals from Tsumeb, Namibia." Rocks and Minerals 91, no. 6 (November 1, 2016): 548-553.

Full Text

Setji, TL, Hong, BD, and Feinglos, MN. "Technosphere insulin: inhaled prandial insulin." Expert opinion on biological therapy 16, no. 1 (January 2016): 111-117. (Review)

PMID
26567896
Full Text

Merwin, RM, Dmitrieva, NO, Honeycutt, LK, Moskovich, AA, Lane, JD, Zucker, NL, Surwit, RS, Feinglos, M, and Kuo, J. "Momentary Predictors of Insulin Restriction Among Adults With Type 1 Diabetes and Eating Disorder Symptomatology." Diabetes care 38, no. 11 (November 2015): 2025-2032.

PMID
26384389
Full Text

Hunter Buskey, RN, Mathieson, K, Leafman, JS, and Feinglos, MN. "The Effect of Blood Glucose Self-Monitoring Among Inmates With Diabetes." Journal of correctional health care : the official journal of the National Commission on Correctional Health Care 21, no. 4 (October 2015): 343-354.

PMID
26276137
Full Text

Spratt, SE, Feinglos, MN, and Willis, JM. "Barriers to care for patients with diabetes in Durham, North Carolina, why are we withholding life-sustaining medications from the patients who need them the most?." Expert Review of Endocrinology & Metabolism 10, no. 5 (September 3, 2015): 459-461.

Full Text

Espeland, MA, Probstfield, J, Hire, D, Redmon, JB, Evans, GW, Coday, M, Lewis, CE, Johnson, KC, Wilmoth, S, Bahnson, J, Dulin, MF, Green, JB, Knowler, WC, Kitabchi, A, Murillo, AL, Osei, K, Rehman, SU, Cushman, WC, Look AHEAD Research Group, , and ACCORD Study Group, . "Systolic Blood Pressure Control Among Individuals With Type 2 Diabetes: A Comparative Effectiveness Analysis of Three Interventions." American journal of hypertension 28, no. 8 (August 2015): 995-1009.

PMID
25666468
Full Text

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