Mary E Klotman, MD

Professor of Medicine
R.J. Reynolds Professor of Medicine
Dean, School of Medicine
Professor in Molecular Genetics and Microbiology
Professor of Pathology
Member of the Duke Human Vaccine Institute
Campus mail DUMC 2927, Davison Building Room 125, Durham, NC 27710
Phone (919) 684-2455
Email address mary.klotman@duke.edu

Dr. Klotman became dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

In Their Words

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
  • Resident, Medicine, Duke University, 1980 - 1983
  • M.D., Duke University, 1980

Publications

Blasi, Maria, Donatella Negri, Celia LaBranche, S Munir Alam, Erich J. Baker, Elizabeth C. Brunner, Morgan A. Gladden, et al. “IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cells..” Commun Biol 1 (2018). https://doi.org/10.1038/s42003-018-0131-6.

PMID
30272013
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Negri, Donatella, Maria Blasi, Celia LaBranche, Robert Parks, Harikrishnan Balachandran, Michelle Lifton, Xiaoying Shen, et al. “Immunization with an SIV-based IDLV Expressing HIV-1 Env 1086 Clade C Elicits Durable Humoral and Cellular Responses in Rhesus Macaques..” Mol Ther 24, no. 11 (November 2016): 2021–32. https://doi.org/10.1038/mt.2016.123.

PMID
27455880
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Chen, Ping, Zhengzi Yi, Weijia Zhang, Mary E. Klotman, and Benjamin K. Chen. “HIV infection-induced transcriptional program in renal tubular epithelial cells activates a CXCR2-driven CD4+ T-cell chemotactic response..” Aids 30, no. 12 (July 31, 2016): 1877–88. https://doi.org/10.1097/QAD.0000000000001153.

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27163710
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Blasi, Maria, J Harris Carpenter, Bala Balakumaran, Andrea Cara, Feng Gao, and Mary E. Klotman. “Identification of HIV-1 genitourinary tract compartmentalization by analyzing the env gene sequences in urine..” Aids 29, no. 13 (August 24, 2015): 1651–57. https://doi.org/10.1097/QAD.0000000000000757.

PMID
26372275
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Michelini, Zuleika, Donatella Negri, Mirella Biava, Silvia Baroncelli, Massimo Spada, Pasqualina Leone, Roberta Bona, et al. “Murine granulocyte-macrophage colony-stimulating factor expressed from a bicistronic simian immunodeficiency virus-based integrase-defective lentiviral vector does not enhance T-cell responses in mice..” Viral Immunol 27, no. 10 (December 2014): 512–20. https://doi.org/10.1089/vim.2014.0062.

PMID
25343523
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Carethers, J. M., S. Coughlin, B. Diamond, S. Erzurum, L. P. Fried, J. L. Jameson, K. Kaushansky, et al. “The imperative to invest in science has never been greater..” J Clin Invest 124, no. 11 (November 3, 2014). https://doi.org/10.1172/JCI79469.

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25365077
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Blasi, Maria, Bala Balakumaran, Ping Chen, Donatella R. M. Negri, Andrea Cara, Benjamin K. Chen, and Mary E. Klotman. “Renal epithelial cells produce and spread HIV-1 via T-cell contact..” Aids 28, no. 16 (October 23, 2014): 2345–53. https://doi.org/10.1097/QAD.0000000000000398.

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25062092
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Carethers, John M., Shaun Coughlin, Betty Diamond, Serpil Erzurum, Linda P. Fried, J Larry Jameson, Kenneth Kaushansky, et al. “The imperative to invest in science has never been greater..” J Clin Invest 124, no. 9 (September 2014): 3680–81. https://doi.org/10.1172/JCI77894.

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25180532
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Rossi, Alessandra, Zuleika Michelini, Pasqualina Leone, Martina Borghi, Maria Blasi, Roberta Bona, Massimo Spada, et al. “Optimization of mucosal responses after intramuscular immunization with integrase defective lentiviral vector..” Plos One 9, no. 9 (2014). https://doi.org/10.1371/journal.pone.0107377.

PMID
25210766
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Micsenyi, Amanda M., Chati Zony, Raymond A. Alvarez, Natasha D. Durham, Benjamin K. Chen, and Mary E. Klotman. “Postintegration HIV-1 infection of cervical epithelial cells mediates contact-dependent productive infection of T cells..” J Infect Dis 208, no. 11 (December 1, 2013): 1756–67. https://doi.org/10.1093/infdis/jit362.

PMID
23908485
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