Dr. Klotman became dean of the Duke School of Medicine in June 2017.
An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.
Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.
Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)
Education and Training
- Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
- Resident, Medicine, Duke University, 1980 - 1983
- M.D., Duke University, 1980
- Interdisciplinary Research Training Program in AIDS
- Medical Scientist Training Program
- Targeting the HIV-1 reservoir with a combination of an IDLV-SIVGag therapeutic vaccine and Fc-engineered bnAbs (R01)
- The Genitourinary Tract as a compartment and reservoir for HIV
- Persistent HIV Infection in the Kidney
- Integrase Defective Lentiviral Vector (IDLV) for HIV Vaccine Development
- Mentoring Patient Oriented Research in Antibiotic-Resistant Bacteria