Mary E Klotman, MD

Professor of Medicine
R.J. Reynolds Distinguished Professor of Medicine
Dean, School of Medicine
Professor in Molecular Genetics and Microbiology
Professor of Pathology
Member of the Duke Human Vaccine Institute
Campus mail DUMC 2927, Davison Building Room 125, Durham, NC 27710
Phone (919) 684-2455
Email address mary.klotman@duke.edu

Dr. Klotman became dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

In Their Words

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
  • Resident, Medicine, Duke University, 1980 - 1983
  • M.D., Duke University, 1980

Publications

Hughes, Kelly, Guray Akturk, Sacha Gnjatic, Benjamin Chen, Mary Klotman, and Maria Blasi. “Proliferation of HIV-infected renal epithelial cells following virus acquisition from infected macrophages.” Aids 34, no. 11 (September 1, 2020): 1581–91. https://doi.org/10.1097/QAD.0000000000002589.

PMID
32701578
Full Text

Lin, Yi-Yu, Ian Belle, Maria Blasi, Min-Nung Huang, Anne F. Buckley, Wes Rountree, Mary E. Klotman, Andrea Cara, and Donatella Negri. “Skeletal Muscle Is an Antigen Reservoir in Integrase-Defective Lentiviral Vector-Induced Long-Term Immunity.” Mol Ther Methods Clin Dev 17 (June 12, 2020): 532–44. https://doi.org/10.1016/j.omtm.2020.03.008.

PMID
32258216
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Blasi, Maria, Hannah Stadtler, Jerry Chang, Marion Hemmersbach-Miller, Christina Wyatt, Paul Klotman, Feng Gao, Cameron Wolfe, and Mary Klotman. “Detection of Donor's HIV Strain in HIV-Positive Kidney-Transplant Recipient.” N Engl J Med 382, no. 2 (January 9, 2020): 195–97. https://doi.org/10.1056/NEJMc1910189.

PMID
31914248
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Blasi, Maria, Elizabeth C. Wescott, Erich J. Baker, Benjamin Mildenberg, Celia LaBranche, Wes Rountree, Barton F. Haynes, et al. “Therapeutic vaccination with IDLV-SIV-Gag results in durable viremia control in chronically SHIV-infected macaques.” Npj Vaccines 5 (2020): 36. https://doi.org/10.1038/s41541-020-0186-5.

PMID
32411399
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Blasi, Maria, Donatella Negri, Celia LaBranche, S Munir Alam, Erich J. Baker, Elizabeth C. Brunner, Morgan A. Gladden, et al. “IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cells.” Commun Biol 1 (2018): 134. https://doi.org/10.1038/s42003-018-0131-6.

PMID
30272013
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Negri, Donatella, Maria Blasi, Celia LaBranche, Robert Parks, Harikrishnan Balachandran, Michelle Lifton, Xiaoying Shen, et al. “Immunization with an SIV-based IDLV Expressing HIV-1 Env 1086 Clade C Elicits Durable Humoral and Cellular Responses in Rhesus Macaques.” Mol Ther 24, no. 11 (November 2016): 2021–32. https://doi.org/10.1038/mt.2016.123.

PMID
27455880
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Chen, Ping, Zhengzi Yi, Weijia Zhang, Mary E. Klotman, and Benjamin K. Chen. “HIV infection-induced transcriptional program in renal tubular epithelial cells activates a CXCR2-driven CD4+ T-cell chemotactic response.” Aids 30, no. 12 (July 31, 2016): 1877–88. https://doi.org/10.1097/QAD.0000000000001153.

PMID
27163710
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Blasi, Maria, J Harris Carpenter, Bala Balakumaran, Andrea Cara, Feng Gao, and Mary E. Klotman. “Identification of HIV-1 genitourinary tract compartmentalization by analyzing the env gene sequences in urine.” Aids 29, no. 13 (August 24, 2015): 1651–57. https://doi.org/10.1097/QAD.0000000000000757.

PMID
26372275
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