Mary E Klotman, MD

Professor of Medicine
R.J. Reynolds Professor of Medicine
Dean, School of Medicine
Professor in Molecular Genetics and Microbiology
Professor of Pathology
Member of the Duke Human Vaccine Institute
Campus mail DUMC 2927, Davison Building Room 125, Durham, NC 27710
Phone (919) 684-2455
Email address mary.klotman@duke.edu

Dr. Klotman became dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

In Their Words

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
  • Resident, Medicine, Duke University, 1980 - 1983
  • M.D., Duke University, 1980

Publications

Micsenyi, AM, Zony, C, Alvarez, RA, Durham, ND, Chen, BK, and Klotman, ME. "Postintegration HIV-1 infection of cervical epithelial cells mediates contact-dependent productive infection of T cells." J Infect Dis 208, no. 11 (December 1, 2013): 1756-1767.

PMID
23908485
Full Text

Hutter, R, Huang, L, Speidl, WS, Giannarelli, C, Trubin, P, Bauriedel, G, Klotman, ME, Fuster, V, Badimon, JJ, and Klotman, PE. "Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheroma." Circulation 128, no. 22 (November 26, 2013): 2351-2363.

Full Text

Hutter, R, Huang, L, Speidl, WS, Giannarelli, C, Trubin, P, Bauriedel, G, Klotman, ME, Fuster, V, Badimon, JJ, and Klotman, PE. "Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheroma." Circulation 128, no. 22 (November 26, 2013): 2351-2363.

PMID
24043300
Full Text

Blasi, M, Negri, D, Santra, S, Parks, R, Shen, X, Tomaras, G, Permar, S, Montefiori, D, LaBranche, C, Ferrari, G, Alam, M, Liao, H, Moody, AM, Haynes, BF, Klotman, ME, and Cara, A. "A Single Immunization with Integrase Defective Lentiviral Vector Expressing gp140 Induces Persistent and Functional Immune Response in Rhesus Monkeys." November 1, 2013.

Scholars@Duke

Todd, RF, Salata, RA, Klotman, ME, Weisfeldt, ML, Katz, JT, Xian, SX, Hearn, DP, and Lipner, RS. "Career outcomes of the graduates of the American Board of Internal Medicine Research Pathway, 1995-2007." Acad Med 88, no. 11 (November 2013): 1747-1753.

PMID
24072121
Full Text

Todd, RF, Salata, RA, Klotman, ME, Weisfeldt, ML, Katz, JT, Xian, SX, Hearn, DP, and Lipner, RS. "Career outcomes of the graduates of the American board of internal medicine research pathway, 1995-2007." Academic Medicine 88, no. 11 (January 1, 2013): 1747-1753.

Full Text

Blasi, M, Rossi, A, Michelini, Z, Leone, P, Perretta, G, Cimarelli, A, Klotman, ME, Negri, D, and Cara, A. "Simian immunodeficiency virus-Vpx as an adjuvant for integrase defective lentiviral vector-based vaccines." RETROVIROLOGY 9 (September 13, 2012).

Full Text

Negri, DRM, Rossi, A, Blasi, M, Michelini, Z, Leone, P, Chiantore, MV, Baroncelli, S, Perretta, G, Cimarelli, A, Klotman, ME, and Cara, A. "Simian immunodeficiency virus-Vpx for improving integrase defective lentiviral vector-based vaccines. (Published online)" Retrovirology 9 (August 22, 2012): 69-.

PMID
22913641
Full Text

Papeta, N, Kiryluk, K, Patel, A, Sterken, R, Kacak, N, Snyder, HJ, Imus, PH, Mhatre, AN, Lawani, AK, Julian, BA, Wyatt, RJ, Novak, J, Wyatt, CM, Ross, MJ, Winston, JA, Klotman, ME, Cohen, DJ, Appel, GB, D'Agati, VD, Klotman, PE, and Gharavi, AG. "APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy." J Am Soc Nephrol 22, no. 11 (November 2011): 1991-1996.

PMID
21997397
Full Text

Chen, P, Chen, BK, Mosoian, A, Hays, T, Ross, MJ, Klotman, PE, and Klotman, ME. "Virological synapses allow HIV-1 uptake and gene expression in renal tubular epithelial cells." J Am Soc Nephrol 22, no. 3 (March 2011): 496-507.

PMID
21335514
Full Text

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