Infectious Diseases

Mary E Klotman, MD

Professor of Medicine
R.J. Reynolds Distinguished Professor of Medicine
Dean, School of Medicine
Professor in Molecular Genetics and Microbiology
Professor of Pathology
Member of the Duke Human Vaccine Institute
Campus mail DUMC 2927, Davison Building Room 125, Durham, NC 27710
Phone (919) 684-2455
Email address mary.klotman@duke.edu

Dr. Klotman became dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

In Their Words

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
  • Resident, Medicine, Duke University, 1980 - 1983
  • M.D., Duke University, 1980

Grants

Publications

Carethers, John M., Shaun Coughlin, Betty Diamond, Serpil Erzurum, Linda P. Fried, J Larry Jameson, Kenneth Kaushansky, et al. “The imperative to invest in science has never been greater.” J Clin Invest 124, no. 9 (September 2014): 3680–81. https://doi.org/10.1172/JCI77894.

PMID
25180532
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Rossi, Alessandra, Zuleika Michelini, Pasqualina Leone, Martina Borghi, Maria Blasi, Roberta Bona, Massimo Spada, et al. “Optimization of mucosal responses after intramuscular immunization with integrase defective lentiviral vector.” Plos One 9, no. 9 (2014): e107377. https://doi.org/10.1371/journal.pone.0107377.

PMID
25210766
Full Text

Micsenyi, Amanda M., Chati Zony, Raymond A. Alvarez, Natasha D. Durham, Benjamin K. Chen, and Mary E. Klotman. “Postintegration HIV-1 infection of cervical epithelial cells mediates contact-dependent productive infection of T cells.” J Infect Dis 208, no. 11 (December 1, 2013): 1756–67. https://doi.org/10.1093/infdis/jit362.

PMID
23908485
Full Text

Hutter, Randolph, Li Huang, Walter S. Speidl, Chiara Giannarelli, Paul Trubin, Gerhard Bauriedel, Mary E. Klotman, Valentin Fuster, Juan J. Badimon, and Paul E. Klotman. “Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheroma.” Circulation 128, no. 22 (November 26, 2013): 2351–63. https://doi.org/10.1161/CIRCULATIONAHA.113.004634.

PMID
24043300
Full Text

Blasi, M., D. Negri, S. Santra, R. Parks, X. Shen, G. Tomaras, S. Permar, et al. “A Single Immunization with Integrase Defective Lentiviral Vector Expressing gp140 Induces Persistent and Functional Immune Response in Rhesus Monkeys.” In Aids Research and Human Retroviruses, 29:A161–A161. MARY ANN LIEBERT, INC, 2013.

Scholars@Duke

Todd, Robert F., Robert A. Salata, Mary E. Klotman, Myron L. Weisfeldt, Joel T. Katz, Sherry X. Xian, Darren P. Hearn, and Rebecca S. Lipner. “Career outcomes of the graduates of the American Board of Internal Medicine Research Pathway, 1995-2007.” Acad Med 88, no. 11 (November 2013): 1747–53. https://doi.org/10.1097/ACM.0b013e3182a7f627.

PMID
24072121
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Blasi, M., A. Rossi, Z. Michelini, P. Leone, G. Perretta, A. Cimarelli, M. E. Klotman, D. Negri, and A. Cara. “Simian immunodeficiency virus-Vpx as an adjuvant for integrase defective lentiviral vector-based vaccines.” Retrovirology 9, no. S2 (September 2012). https://doi.org/10.1186/1742-4690-9-s2-p293.

Full Text

Negri, Donatella R. M., Alessandra Rossi, Maria Blasi, Zuleika Michelini, Pasqualina Leone, Maria Vincenza Chiantore, Silvia Baroncelli, et al. “Simian immunodeficiency virus-Vpx for improving integrase defective lentiviral vector-based vaccines.” Retrovirology 9 (August 22, 2012): 69. https://doi.org/10.1186/1742-4690-9-69.

PMID
22913641
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Papeta, Natalia, Krzysztof Kiryluk, Ami Patel, Roel Sterken, Nilgun Kacak, Holly J. Snyder, Phil H. Imus, et al. “APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy.” J Am Soc Nephrol 22, no. 11 (November 2011): 1991–96. https://doi.org/10.1681/ASN.2011040434.

PMID
21997397
Full Text

Jao, Jennifer, Dennis Palmer, Ine Leus, Pius Tih, Mukta Baweja, Mary Klotman, Rhoda Sperling, and Christina Wyatt. “Prevalence and predictors of proteinuria in HIV-infected and uninfected pregnant women in Cameroon.” Nephrol Dial Transplant 26, no. 9 (September 2011): 3051–53. https://doi.org/10.1093/ndt/gfr310.

PMID
21719713
Full Text

Pages