Mary E Klotman, MD

Professor of Medicine
R.J. Reynolds Distinguished Professor of Medicine
Dean, School of Medicine
Professor in Molecular Genetics and Microbiology
Professor of Pathology
Member of the Duke Human Vaccine Institute
Campus mail DUMC 2927, Davison Building Room 125, Durham, NC 27710
Phone (919) 684-2455
Email address

Dr. Klotman became Dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

In Their Words

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
  • Resident, Medicine, Duke University, 1980 - 1983
  • M.D., Duke University, 1980


Peters, W. P., A. Stuart, M. Klotman, C. Gilbert, R. B. Jones, E. J. Shpall, J. Gockerman, R. C. Bast, and J. O. Moore. “High-dose combination cyclophosphamide, cisplatin, and melphalan with autologous bone marrow support. A clinical and pharmacologic study.” Cancer Chemother Pharmacol 23, no. 6 (1989): 377–83.

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Buchbinder, A., S. F. Josephs, D. Ablashi, S. Z. Salahuddin, M. E. Klotman, M. Manak, G. R. Krueger, F. Wong-Staal, and R. C. Gallo. “Polymerase chain reaction amplification and in situ hybridization for the detection of human B-lymphotropic virus.” J Virol Methods 21, no. 1–4 (September 1988): 191–97.

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Klotman, M. E., and J. D. Hamilton. “Cytomegalovirus pneumonia.” Semin Respir Infect 2, no. 2 (June 1987): 95–103.


Klotman, M. E. “Laboratory detection of urinary tract infections.” Kidney 18, no. 1 (January 1, 1985): 1–4.