Mary E Klotman, MD

Professor of Medicine
R.J. Reynolds Professor of Medicine
Dean, School of Medicine
Professor in Molecular Genetics and Microbiology
Professor of Pathology
Member of the Duke Human Vaccine Institute
Campus mail DUMC 2927, Davison Building Room 125, Durham, NC 27710
Phone (919) 684-2455
Email address mary.klotman@duke.edu

Dr. Klotman became dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

In Their Words

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
  • Resident, Medicine, Duke University, 1980 - 1983
  • M.D., Duke University, 1980

Publications

Negri, Donatella R. M., Roberta Bona, Zuleika Michelini, Pasqualina Leone, Iole Macchia, Mary E. Klotman, Mirella Salvatore, and Andrea Cara. “Transduction of human antigen-presenting cells with integrase-defective lentiviral vector enables functional expansion of primed antigen-specific CD8(+) T cells..” Hum Gene Ther 21, no. 8 (August 2010): 1029–35. https://doi.org/10.1089/hum.2009.200.

PMID
20210625
Full Text

Mosoian, Arevik, Avelino Teixeira, Colin S. Burns, Leif E. Sander, G Luca Gusella, Cijiang He, J Magarian Blander, Paul Klotman, and Mary E. Klotman. “Prothymosin-alpha inhibits HIV-1 via Toll-like receptor 4-mediated type I interferon induction..” Proc Natl Acad Sci U S A 107, no. 22 (June 1, 2010): 10178–83. https://doi.org/10.1073/pnas.0914870107.

PMID
20479248
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Snyder, Alexandra, Zygimantas C. Alsauskas, Jeremy S. Leventhal, Paul E. Rosenstiel, Pengfei Gong, Justin J. K. Chan, Kevin Barley, et al. “HIV-1 viral protein r induces ERK and caspase-8-dependent apoptosis in renal tubular epithelial cells..” Aids (London, England) 24, no. 8 (May 2010): 1107–19. https://doi.org/10.1097/QAD.0b013e328337b0ab.

PMID
20404718
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Ding, Jian, Aprille Rapista, Natalia Teleshova, Goar Mosoyan, Gary A. Jarvis, Mary E. Klotman, and Theresa L. Chang. “Neisseria gonorrhoeae enhances HIV-1 infection of primary resting CD4+ T cells through TLR2 activation..” J Immunol 184, no. 6 (March 15, 2010): 2814–24. https://doi.org/10.4049/jimmunol.0902125.

PMID
20147631
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Negri, Donatella R. M., Zuleika Michelini, Silvia Baroncelli, Massimo Spada, Silvia Vendetti, Roberta Bona, Pasqualina Leone, Mary E. Klotman, and Andrea Cara. “Nonintegrating Lentiviral Vector-Based Vaccine Efficiently Induces Functional and Persistent CD8+ T Cell Responses in Mice..” J Biomed Biotechnol 2010 (2010). https://doi.org/10.1155/2010/534501.

PMID
20508727
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Snyder, Alexandra, Zygimantas Alsauskas, Pengfei Gong, Paul E. Rosenstiel, Mary E. Klotman, Paul E. Klotman, and Michael J. Ross. “FAT10: a novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy..” Journal of Virology 83, no. 22 (November 2009): 11983–88. https://doi.org/10.1128/JVI.00034-09.

PMID
19726511
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Factor, Stephanie H., and Mary E. Klotman. “Zoonotic infections: an emerging threat to human health..” Mt Sinai J Med 76, no. 5 (October 2009): 419–20. https://doi.org/10.1002/msj.20141.

PMID
19787651
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Feng, Xiaobei, Ting-Chi Lu, Peter Y. Chuang, Wei Fang, Krishna Ratnam, Huabao Xiong, Xinshou Ouyang, et al. “Reduction of Stat3 activity attenuates HIV-induced kidney injury..” J Am Soc Nephrol 20, no. 10 (October 2009): 2138–46. https://doi.org/10.1681/ASN.2008080879.

PMID
19608706
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Rosenstiel, Paul E., Justin Chan, Alexander Snyder, Vicente Planelles, Vivette D. D’Agati, Paul E. Klotman, and Mary E. Klotman. “HIV-1 Vpr activates the DNA damage response in renal tubule epithelial cells..” Aids 23, no. 15 (September 24, 2009): 2054–56. https://doi.org/10.1097/QAD.0b013e32833088a0.

PMID
19657269
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Chen, Wen-Hua, Vaclav Janout, Masaharu Kondo, Arevik Mosoian, Goar Mosoyan, Ravil R. Petrov, Mary E. Klotman, and Steven L. Regen. “A fine line between molecular umbrella transport and ionophoric activity..” Bioconjug Chem 20, no. 9 (September 2009): 1711–15. https://doi.org/10.1021/bc900246u.

PMID
19689127
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