Mary E Klotman, MD

Professor of Medicine
R.J. Reynolds Professor of Medicine
Dean, School of Medicine
Professor in Molecular Genetics and Microbiology
Professor of Pathology
Member of the Duke Human Vaccine Institute
Campus mail DUMC 2927, Davison Building Room 125, Durham, NC 27710
Phone (919) 684-2455
Email address mary.klotman@duke.edu

Dr. Klotman became dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

In Their Words

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
  • Resident, Medicine, Duke University, 1980 - 1983
  • M.D., Duke University, 1980

Publications

Jao, J, Palmer, D, Leus, I, Tih, P, Baweja, M, Klotman, M, Sperling, R, and Wyatt, C. "Prevalence and predictors of proteinuria in HIV-infected and uninfected pregnant women in Cameroon." Nephrology Dialysis Transplantation 26, no. 9 (2011): 3051-3053.

PMID
21719713
Full Text

Ding, J, Rapista, A, Teleshova, N, Lu, W, Klotman, ME, and Chang, TL. "Mucosal human defensins 5 and 6 antagonize the anti-HIV activity of candidate polyanion microbicides." J Innate Immun 3, no. 2 (2011): 208-212.

PMID
21160168
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Tuyama, AC, Hong, F, Saiman, Y, Wang, C, Ozkok, D, Mosoian, A, Chen, P, Chen, BK, Klotman, ME, and Bansal, MB. "Human immunodeficiency virus (HIV)-1 infects human hepatic stellate cells and promotes collagen I and monocyte chemoattractant protein-1 expression: implications for the pathogenesis of HIV/hepatitis C virus-induced liver fibrosis." Hepatology 52, no. 2 (August 2010): 612-622.

PMID
20683959
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Negri, DRM, Bona, R, Michelini, Z, Leone, P, Macchia, I, Klotman, ME, Salvatore, M, and Cara, A. "Transduction of human antigen-presenting cells with integrase-defective lentiviral vector enables functional expansion of primed antigen-specific CD8(+) T cells." Hum Gene Ther 21, no. 8 (August 2010): 1029-1035.

PMID
20210625
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Mosoian, A, Teixeira, A, Burns, CS, Sander, LE, Gusella, GL, He, C, Blander, JM, Klotman, P, and Klotman, ME. "Prothymosin-alpha inhibits HIV-1 via Toll-like receptor 4-mediated type I interferon induction." Proc Natl Acad Sci U S A 107, no. 22 (June 1, 2010): 10178-10183.

PMID
20479248
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Snyder, A, Alsauskas, ZC, Leventhal, JS, Rosenstiel, PE, Gong, P, Chan, JJK, Barley, K, He, JC, Klotman, ME, Ross, MJ, and Klotman, PE. "HIV-1 viral protein r induces ERK and caspase-8-dependent apoptosis in renal tubular epithelial cells." AIDS 24, no. 8 (May 15, 2010): 1107-1119.

PMID
20404718
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Ding, J, Rapista, A, Teleshova, N, Mosoyan, G, Jarvis, GA, Klotman, ME, and Chang, TL. "Neisseria gonorrhoeae enhances HIV-1 infection of primary resting CD4+ T cells through TLR2 activation." J Immunol 184, no. 6 (March 15, 2010): 2814-2824.

PMID
20147631
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Negri, DRM, Michelini, Z, Baroncelli, S, Spada, M, Vendetti, S, Bona, R, Leone, P, Klotman, ME, and Cara, A. "Nonintegrating Lentiviral Vector-Based Vaccine Efficiently Induces Functional and Persistent CD8+ T Cell Responses in Mice." J Biomed Biotechnol 2010 (2010): 534501-.

PMID
20508727
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Chang, TL, and Klotman, M. "Defensins and HIV infection." Soluble Factors Mediating Innate Immune Responses to HIV Infection (2010): 51-63.

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Snyder, A, Alsauskas, Z, Gong, P, Rosenstiel, PE, Klotman, ME, Klotman, PE, and Ross, MJ. "FAT10: a novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy." J Virol 83, no. 22 (November 2009): 11983-11988.

PMID
19726511
Full Text

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