Mary E Klotman, MD

Professor of Medicine
R.J. Reynolds Professor of Medicine
Dean, School of Medicine
Professor in Molecular Genetics and Microbiology
Professor of Pathology
Member of the Duke Human Vaccine Institute
Campus mail DUMC 2927, Davison Building Room 125, Durham, NC 27710
Phone (919) 684-2455
Email address mary.klotman@duke.edu

Dr. Klotman became dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

In Their Words

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
  • Resident, Medicine, Duke University, 1980 - 1983
  • M.D., Duke University, 1980

Publications

Chen, P, Chen, BK, Mosoian, A, Hays, T, Ross, MJ, Klotman, PE, and Klotman, ME. "Virological synapses allow HIV-1 uptake and gene expression in renal tubular epithelial cells." Journal of the American Society of Nephrology : Jasn 22, no. 3 (March 2011): 496-507.

PMID
21335514
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Ding, J, Rapista, A, Teleshova, N, Lu, W, Klotman, ME, and Chang, TL. "Mucosal human defensins 5 and 6 antagonize the anti-HIV activity of candidate polyanion microbicides." Journal of Innate Immunity 3, no. 2 (January 2011): 208-212.

PMID
21160168
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Chang, TL, and Klotman, M. "Defensins and HIV infection." (December 1, 2010): 51-63. (Chapter)

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Tuyama, AC, Hong, F, Saiman, Y, Wang, C, Ozkok, D, Mosoian, A, Chen, P, Chen, BK, Klotman, ME, and Bansal, MB. "Human immunodeficiency virus (HIV)-1 infects human hepatic stellate cells and promotes collagen I and monocyte chemoattractant protein-1 expression: implications for the pathogenesis of HIV/hepatitis C virus-induced liver fibrosis." Hepatology (Baltimore, Md.) 52, no. 2 (August 2010): 612-622.

PMID
20683959
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Negri, DRM, Bona, R, Michelini, Z, Leone, P, Macchia, I, Klotman, ME, Salvatore, M, and Cara, A. "Transduction of human antigen-presenting cells with integrase-defective lentiviral vector enables functional expansion of primed antigen-specific CD8(+) T cells." Human Gene Therapy 21, no. 8 (August 2010): 1029-1035.

PMID
20210625
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Mosoian, A, Teixeira, A, Burns, CS, Sander, LE, Gusella, GL, He, C, Blander, JM, Klotman, P, and Klotman, ME. "Prothymosin-alpha inhibits HIV-1 via Toll-like receptor 4-mediated type I interferon induction." Proceedings of the National Academy of Sciences of the United States of America 107, no. 22 (June 2010): 10178-10183.

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20479248
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Snyder, A, Alsauskas, ZC, Leventhal, JS, Rosenstiel, PE, Gong, P, Chan, JJK, Barley, K, He, JC, Klotman, ME, Ross, MJ, and Klotman, PE. "HIV-1 viral protein r induces ERK and caspase-8-dependent apoptosis in renal tubular epithelial cells." Aids (London, England) 24, no. 8 (May 2010): 1107-1119.

PMID
20404718
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Ding, J, Rapista, A, Teleshova, N, Mosoyan, G, Jarvis, GA, Klotman, ME, and Chang, TL. "Neisseria gonorrhoeae enhances HIV-1 infection of primary resting CD4+ T cells through TLR2 activation." Journal of Immunology (Baltimore, Md. : 1950) 184, no. 6 (March 2010): 2814-2824.

PMID
20147631
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Negri, DRM, Michelini, Z, Baroncelli, S, Spada, M, Vendetti, S, Bona, R, Leone, P, Klotman, ME, and Cara, A. "Nonintegrating Lentiviral Vector-Based Vaccine Efficiently Induces Functional and Persistent CD8+ T Cell Responses in Mice." Journal of Biomedicine & Biotechnology 2010 (January 2010): 534501-null.

PMID
20508727
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Snyder, A, Alsauskas, Z, Gong, P, Rosenstiel, PE, Klotman, ME, Klotman, PE, and Ross, MJ. "FAT10: a novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy." Journal of Virology 83, no. 22 (November 2009): 11983-11988.

PMID
19726511
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