Mary E Klotman, MD

Professor of Medicine
R.J. Reynolds Professor of Medicine
Dean, School of Medicine
Professor in Molecular Genetics and Microbiology
Professor of Pathology
Member of the Duke Human Vaccine Institute
Campus mail DUMC 2927, Davison Building Room 125, Durham, NC 27710
Phone (919) 684-2455
Email address mary.klotman@duke.edu

Dr. Klotman became dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

In Their Words

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
  • Resident, Medicine, Duke University, 1980 - 1983
  • M.D., Duke University, 1980

Publications

Feng, X, Lu, T-C, Chuang, PY, Fang, W, Ratnam, K, Xiong, H, Ouyang, X, Shen, Y, Levy, DE, Hyink, D, Klotman, M, D'Agati, V, Iyengar, R, Klotman, PE, and He, JC. "Reduction of Stat3 activity attenuates HIV-induced kidney injury." Journal of the American Society of Nephrology : Jasn 20, no. 10 (October 2009): 2138-2146.

PMID
19608706
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Rosenstiel, PE, Chan, J, Snyder, A, Planelles, V, D'Agati, VD, Klotman, PE, and Klotman, ME. "HIV-1 Vpr activates the DNA damage response in renal tubule epithelial cells." Aids (London, England) 23, no. 15 (September 2009): 2054-2056.

PMID
19657269
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Chen, W-H, Janout, V, Kondo, M, Mosoian, A, Mosoyan, G, Petrov, RR, Klotman, ME, and Regen, SL. "A fine line between molecular umbrella transport and ionophoric activity." Bioconjugate Chemistry 20, no. 9 (September 2009): 1711-1715.

PMID
19689127
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Michelini, Z, Negri, DRM, Baroncelli, S, Spada, M, Leone, P, Bona, R, Klotman, ME, and Cara, A. "Development and use of SIV-based Integrase defective lentiviral vector for immunization." Vaccine 27, no. 34 (July 2009): 4622-4629.

PMID
19523909
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Sachdev, DD, Zerhouni-Layachi, B, Ortigoza, M, Profy, AT, Tuen, M, Hioe, CE, and Klotman, ME. "The differential binding and activity of PRO 2000 against diverse HIV-1 envelopes." Journal of Acquired Immune Deficiency Syndromes (1999) 51, no. 2 (June 2009): 125-129.

PMID
19349871
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Wyatt, CM, Morgello, S, Katz-Malamed, R, Wei, C, Klotman, ME, Klotman, PE, and D'Agati, VD. "The spectrum of kidney disease in patients with AIDS in the era of antiretroviral therapy." Kidney International 75, no. 4 (February 2009): 428-434.

PMID
19052538
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Abbadessa, G, Accolla, R, Aiuti, F, Albini, A, Aldovini, A, Alfano, M, Antonelli, G, Bartholomew, C, Bentwich, Z, Bertazzoni, U, Berzofsky, JA, Biberfeld, P, Boeri, E, Buonaguro, L, Buonaguro, FM, Bukrinsky, M, Burny, A, Caruso, A, Cassol, S, Chandra, P, Ceccherini-Nelli, L, Chieco-Bianchi, L, Clerici, M, Colombini-Hatch, S, de Giuli Morghen, C, de Maria, A, de Rossi, A, Dierich, M, Della-Favera, R, Dolei, A, Douek, D, Erfle, V, Felber, B, Fiorentini, S, Franchini, G, Gershoni, JM, Gotch, F, Green, P, Greene, WC, Hall, W, Haseltine, W, Jacobson, S, Kallings, LO, Kalyanaraman, VS, Katinger, H, Khalili, K, Klein, G, Klein, E, Klotman, M, Klotman, P, Kotler, M, Kurth, R, Lafeuillade, A, La Placa, M, Lewis, J, Lillo, F, Lisziewicz, J, Lomonico, A, Lopalco, L, Lori, F, Lusso, P, Macchi, B, Malim, M, Margolis, L, Markham, PD, McClure, M, Miller, N, Mingari, MC, Moretta, L, Noonan, D, O'Brien, S, Okamoto, T, Pal, R, Palese, P, Panet, A, Pantaleo, G, Pavlakis, G, Pistello, M, Plotkin, S, Poli, G, Pomerantz, R, Radaelli, A, Robertguroff, M, Roederer, M, Sarngadharan, MG, Schols, D, Secchiero, P, Shearer, G, Siccardi, A, Stevenson, M, Svoboda, J, Tartaglia, J, Torelli, G, Tornesello, ML, Tschachler, E, Vaccarezza, M, Vallbracht, A, van Lunzen, J, Varnier, O, Vicenzi, E, von Melchner, H, Witz, I, Zagury, D, Zagury, J-F, Zauli, G, and Zipeto, D. "Unsung hero Robert C. Gallo." Science (New York, N.Y.) 323, no. 5911 (January 2009): 206-207. (Letter)

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19131607
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Radbill, BD, Wyatt, CM, Vassalotti, JA, Klotman, ME, and Klotman, PE. "Hepatitis B- and HIV-Related Renal Diseases." (December 1, 2008): 272-280. (Chapter)

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Vargas, J, Klotman, ME, and Cara, A. "Conditionally replicating lentiviral-hybrid episomal vectors for suicide gene therapy." Antiviral Research 80, no. 3 (December 2008): 288-294.

PMID
18647620
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Rosenstiel, PE, Gruosso, T, Letourneau, AM, Chan, JJ, LeBlanc, A, Husain, M, Najfeld, V, Planelles, V, D'Agati, VD, Klotman, ME, and Klotman, PE. "HIV-1 Vpr inhibits cytokinesis in human proximal tubule cells." Kidney International 74, no. 8 (October 2008): 1049-1058.

PMID
18614999
Full Text

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