Mary E Klotman, MD

Professor of Medicine
R.J. Reynolds Professor of Medicine
Dean, School of Medicine
Professor in Molecular Genetics and Microbiology
Professor of Pathology
Member of the Duke Human Vaccine Institute
Campus mail DUMC 2927, Davison Building Room 125, Durham, NC 27710
Phone (919) 684-2455
Email address mary.klotman@duke.edu

Dr. Klotman became dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

In Their Words

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
  • Resident, Medicine, Duke University, 1980 - 1983
  • M.D., Duke University, 1980

Publications

Michelini, Zuleika, Donatella R. M. Negri, Silvia Baroncelli, Massimo Spada, Pasqualina Leone, Roberta Bona, Mary E. Klotman, and Andrea Cara. “Development and use of SIV-based Integrase defective lentiviral vector for immunization..” Vaccine 27, no. 34 (July 23, 2009): 4622–29. https://doi.org/10.1016/j.vaccine.2009.05.070.

PMID
19523909
Full Text

Sachdev, Darpun D., Bouchra Zerhouni-Layachi, Mila Ortigoza, Albert T. Profy, Michael Tuen, Catarina E. Hioe, and Mary E. Klotman. “The differential binding and activity of PRO 2000 against diverse HIV-1 envelopes..” Journal of Acquired Immune Deficiency Syndromes (1999) 51, no. 2 (June 2009): 125–29. https://doi.org/10.1097/QAI.0b013e31819f9e31.

PMID
19349871
Full Text

Wyatt, Christina M., Susan Morgello, Rebecca Katz-Malamed, Catherine Wei, Mary E. Klotman, Paul E. Klotman, and Vivette D. D’Agati. “The spectrum of kidney disease in patients with AIDS in the era of antiretroviral therapy..” Kidney Int 75, no. 4 (February 2009): 428–34. https://doi.org/10.1038/ki.2008.604.

PMID
19052538
Full Text

Abbadessa, Giovanni, Roberto Accolla, Fernando Aiuti, Adriana Albini, Anna Aldovini, Massimo Alfano, Guido Antonelli, et al. “Unsung hero Robert C. Gallo..” Science 323, no. 5911 (January 9, 2009): 206–7. https://doi.org/10.1126/science.323.5911.206.

PMID
19131607
Full Text

Rosenstiel, Paul E., Tina Gruosso, Audrey M. Letourneau, Justin J. Chan, Amanda LeBlanc, Mohammad Husain, Vesna Najfeld, et al. “HIV-1 Vpr inhibits cytokinesis in human proximal tubule cells..” Kidney Int 74, no. 8 (October 2008): 1049–58. https://doi.org/10.1038/ki.2008.303.

PMID
18614999
Full Text

Klotman, Mary E., Aprille Rapista, Natalia Teleshova, Amanda Micsenyi, Gary A. Jarvis, Wuyuan Lu, Edith Porter, and Theresa L. Chang. “Neisseria gonorrhoeae-induced human defensins 5 and 6 increase HIV infectivity: role in enhanced transmission..” J Immunol 180, no. 9 (May 1, 2008): 6176–85. https://doi.org/10.4049/jimmunol.180.9.6176.

PMID
18424739
Full Text

Teleshova, Natalia, Theresa Chang, Albert Profy, and Mary E. Klotman. “Inhibitory effect of PRO 2000, a candidate microbicide, on dendritic cell-mediated human immunodeficiency virus transfer..” Antimicrobial Agents and Chemotherapy 52, no. 5 (May 2008): 1751–58. https://doi.org/10.1128/AAC.00707-07.

PMID
18332174
Full Text

Eugenin, Eliseo A., Susan Morgello, Mary E. Klotman, Arevik Mosoian, Patrick A. Lento, Joan W. Berman, and Alison D. Schecter. “Human immunodeficiency virus (HIV) infects human arterial smooth muscle cells in vivo and in vitro: implications for the pathogenesis of HIV-mediated vascular disease..” Am J Pathol 172, no. 4 (April 2008): 1100–1111. https://doi.org/10.2353/ajpath.2008.070457.

PMID
18310503
Full Text

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