Mary E Klotman, MD

Professor of Medicine
R.J. Reynolds Professor of Medicine
Dean, School of Medicine
Professor in Molecular Genetics and Microbiology
Professor of Pathology
Member of the Duke Human Vaccine Institute
Campus mail DUMC 2927, Davison Building Room 125, Durham, NC 27710
Phone (919) 684-2455
Email address mary.klotman@duke.edu

Dr. Klotman became dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

In Their Words

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
  • Resident, Medicine, Duke University, 1980 - 1983
  • M.D., Duke University, 1980

Publications

Rosenstiel, PE, Gruosso, T, Letourneau, AM, Chan, JJ, LeBlanc, A, Husain, M, Najfeld, V, Planelles, V, D'Agati, VD, Klotman, ME, and Klotman, PE. "HIV-1 Vpr inhibits cytokinesis in human proximal tubule cells." Kidney International 74, no. 8 (October 2008): 1049-1058.

PMID
18614999
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Klotman, ME, Rapista, A, Teleshova, N, Micsenyi, A, Jarvis, GA, Lu, W, Porter, E, and Chang, TL. "Neisseria gonorrhoeae-induced human defensins 5 and 6 increase HIV infectivity: role in enhanced transmission." Journal of Immunology (Baltimore, Md. : 1950) 180, no. 9 (May 2008): 6176-6185.

PMID
18424739
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Teleshova, N, Chang, T, Profy, A, and Klotman, ME. "Inhibitory effect of PRO 2000, a candidate microbicide, on dendritic cell-mediated human immunodeficiency virus transfer." Antimicrobial Agents and Chemotherapy 52, no. 5 (May 2008): 1751-1758.

PMID
18332174
Full Text

Eugenin, EA, Morgello, S, Klotman, ME, Mosoian, A, Lento, PA, Berman, JW, and Schecter, AD. "Human immunodeficiency virus (HIV) infects human arterial smooth muscle cells in vivo and in vitro: implications for the pathogenesis of HIV-mediated vascular disease." The American Journal of Pathology 172, no. 4 (April 2008): 1100-1111.

PMID
18310503
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Tuyama, AC, Hong, F, Schecter, AD, Mosoian, A, Chen, BK, Chen, P, Klotman, ME, and Bansal, MB. "HIV entry and replication stellate cells promotes cellular activation and fibrogenesis: Implications for hepatic fibrosis in HIV/HCV co-infection." 58th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases. Boston, MA. November 2, 2007 - November 6, 2007.: JOHN WILEY & SONS INC, October 1, 2007.

Scholars@Duke

Tuyama, AC, Hong, F, Schecter, AD, Mosoian, A, Chen, BK, Chen, P, Klotman, ME, and Bansal, MB. "HIV entry and replication stellate cells promotes cellular activation and fibrogenesis: Implications for hepatic fibrosis in HIV/HCV co-infection." 58th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases. Boston, MA. November 2, 2007 - November 6, 2007.: JOHN WILEY & SONS INC, October 1, 2007.

Scholars@Duke

Wyatt, CM, Winston, JA, Malvestutto, CD, Fishbein, DA, Barash, I, Cohen, AJ, Klotman, ME, and Klotman, PE. "Chronic kidney disease in HIV infection: an urban epidemic." Aids (London, England) 21, no. 15 (October 2007): 2101-2103.

PMID
17885301
Full Text

Chang, TL, Teleshova, N, Rapista, A, Paluch, M, Anderson, RA, Waller, DP, Zaneveld, LJD, Granelli-Piperno, A, and Klotman, ME. "SAMMA, a mandelic acid condensation polymer, inhibits dendritic cell-mediated HIV transmission." Febs Letters 581, no. 24 (October 2007): 4596-4602.

PMID
17825297
Full Text

Negri, DRM, Michelini, Z, Baroncelli, S, Spada, M, Vendetti, S, Buffa, V, Bona, R, Leone, P, Klotman, ME, and Cara, A. "Successful immunization with a single injection of non-integrating lentiviral vector." Molecular Therapy 15, no. 9 (September 1, 2007): 1716-1723. (Academic Article)

Full Text

Negri, DRM, Michelini, Z, Baroncelli, S, Spada, M, Vendetti, S, Buffa, V, Bona, R, Leone, P, Klotman, ME, and Cara, A. "Successful immunization with a single injection of non-integrating lentiviral vector." Molecular Therapy 15, no. 9 (September 1, 2007): 1716-1723. (Academic Article)

Full Text

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