Mary E Klotman, MD

Professor of Medicine
R.J. Reynolds Distinguished Professor of Medicine
Dean, School of Medicine
Professor in Molecular Genetics and Microbiology
Professor of Pathology
Member of the Duke Human Vaccine Institute
Campus mail DUMC 2927, Davison Building Room 125, Durham, NC 27710
Phone (919) 684-2455
Email address

Dr. Klotman became Dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

In Their Words

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
  • Resident, Medicine, Duke University, 1980 - 1983
  • M.D., Duke University, 1980


Chang, Theresa L., Natalia Teleshova, Aprille Rapista, Maciej Paluch, Robert A. Anderson, Donald P. Waller, Lourens J. D. Zaneveld, Angela Granelli-Piperno, and Mary E. Klotman. “SAMMA, a mandelic acid condensation polymer, inhibits dendritic cell-mediated HIV transmission.” Febs Lett 581, no. 24 (October 2, 2007): 4596–4602.

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Wyatt, Christina M., Jonathan A. Winston, Carlos D. Malvestutto, Dawn A. Fishbein, Irina Barash, Alan J. Cohen, Mary E. Klotman, and Paul E. Klotman. “Chronic kidney disease in HIV infection: an urban epidemic.” Aids 21, no. 15 (October 1, 2007): 2101–3.

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Tuyama, Ana C., Feng Hong, Alison D. Schecter, Arevik Mosoian, Benjamin K. Chen, Ping Chen, Mary E. Klotman, and Meena B. Bansal. “HIV entry and replication stellate cells promotes cellular activation and fibrogenesis: Implications for hepatic fibrosis in HIV/HCV co-infection.” In Hepatology, 46:291A-291A. JOHN WILEY & SONS INC, 2007.


Salvatore, Mirella, Adolfo Garcia-Sastre, Piotr Ruchala, Robert I. Lehrer, Theresa Chang, and Mary E. Klotman. “alpha-Defensin inhibits influenza virus replication by cell-mediated mechanism(s).” J Infect Dis 196, no. 6 (September 15, 2007): 835–43.

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Mosoian, Arevik, Avelino Teixeira, Colin S. Burns, Gregory Khitrov, Weijia Zhang, Luca Gusella, Paul Klotman, and Mary Klotman. “Influence of prothymosin-alpha on HIV-1 target cells.” Ann N Y Acad Sci 1112 (September 2007): 269–85.

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Negri, Donatella R. M., Zuleika Michelini, Silvia Baroncelli, Massimo Spada, Silvia Vendetti, Viviana Buffa, Roberta Bona, Pasqualina Leone, Mary E. Klotman, and Andrea Cara. “Successful immunization with a single injection of non-integrating lentiviral vector.” Mol Ther 15, no. 9 (September 2007): 1716–23.

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Kaufman, Lewis, Guozhe Yang, Kayo Hayashi, James R. Ashby, Li Huang, Michael J. Ross, Mary E. Klotman, and Paul E. Klotman. “The homophilic adhesion molecule sidekick-1 contributes to augmented podocyte aggregation in HIV-associated nephropathy.” Faseb J 21, no. 7 (May 2007): 1367–75.

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Cara, Andrea, and Mary E. Klotman. “Retroviral E-DNA: persistence and gene expression in nondividing immune cells.” J Leukoc Biol 80, no. 5 (November 2006): 1013–17.

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Tuyama, Ana C. G., Natalia Cheshenko, Maria J. Carlucci, Jin-Hua Li, Cindy L. Goldberg, Donald P. Waller, Robert A. Anderson, et al. “ACIDFORM inactivates herpes simplex virus and prevents genital herpes in a mouse model: optimal candidate for microbicide combinations.” J Infect Dis 194, no. 6 (September 15, 2006): 795–803.

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