Mary E Klotman, MD

Professor of Medicine
R.J. Reynolds Professor of Medicine
Dean, School of Medicine
Professor in Molecular Genetics and Microbiology
Professor of Pathology
Member of the Duke Human Vaccine Institute
Campus mail DUMC 2927, Davison Building Room 125, Durham, NC 27710
Phone (919) 684-2455
Email address mary.klotman@duke.edu

Dr. Klotman became dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

In Their Words

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
  • Resident, Medicine, Duke University, 1980 - 1983
  • M.D., Duke University, 1980

Publications

Mosoian, A, Teixeira, A, Burns, CS, Khitrov, G, Zhang, W, Gusella, L, Klotman, P, and Klotman, M. "Influence of prothymosin-alpha on HIV-1 target cells." Annals of the New York Academy of Sciences 1112 (September 2007): 269-285. (Review)

PMID
17600282
Full Text

Salvatore, M, Garcia-Sastre, A, Ruchala, P, Lehrer, RI, Chang, T, and Klotman, ME. "alpha-Defensin inhibits influenza virus replication by cell-mediated mechanism(s)." The Journal of Infectious Diseases 196, no. 6 (September 2007): 835-843.

PMID
17703413
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Negri, DRM, Michelini, Z, Baroncelli, S, Spada, M, Vendetti, S, Buffa, V, Bona, R, Leone, P, Klotman, ME, and Cara, A. "Successful immunization with a single injection of non-integrating lentiviral vector." Molecular Therapy : the Journal of the American Society of Gene Therapy 15, no. 9 (September 2007): 1716-1723.

PMID
17593926
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Bhadelia, N, Klotman, M, and Caplivski, D. "The HIV-positive traveler." The American Journal of Medicine 120, no. 7 (July 2007): 574-580. (Review)

PMID
17602926
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Kaufman, L, Yang, G, Hayashi, K, Ashby, JR, Huang, L, Ross, MJ, Klotman, ME, and Klotman, PE. "The homophilic adhesion molecule sidekick-1 contributes to augmented podocyte aggregation in HIV-associated nephropathy." Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 21, no. 7 (May 2007): 1367-1375.

PMID
17307840
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Cara, A, and Klotman, ME. "Retroviral E-DNA: persistence and gene expression in nondividing immune cells." Journal of Leukocyte Biology 80, no. 5 (November 2006): 1013-1017. (Review)

PMID
16923918
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Tuyama, ACG, Cheshenko, N, Carlucci, MJ, Li, J-H, Goldberg, CL, Waller, DP, Anderson, RA, Profy, AT, Klotman, ME, Keller, MJ, and Herold, BC. "ACIDFORM inactivates herpes simplex virus and prevents genital herpes in a mouse model: optimal candidate for microbicide combinations." The Journal of Infectious Diseases 194, no. 6 (September 2006): 795-803.

PMID
16941346
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Liu, X, Mosoian, A, Li-Yun Chang, T, Zerhouni-Layachi, B, Snyder, A, Jarvis, GA, and Klotman, ME. "Gonococcal lipooligosaccharide suppresses HIV infection in human primary macrophages through induction of innate immunity." The Journal of Infectious Diseases 194, no. 6 (September 2006): 751-759.

PMID
16941340
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Mosoian, A, Teixeira, A, High, AA, Christian, RE, Hunt, DF, Shabanowitz, J, Liu, X, and Klotman, M. "Novel function of prothymosin alpha as a potent inhibitor of human immunodeficiency virus type 1 gene expression in primary macrophages." Journal of Virology 80, no. 18 (September 2006): 9200-9206.

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16940531
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Klotman, ME, and Chang, TL. "Defensins in innate antiviral immunity." Nature Reviews. Immunology 6, no. 6 (June 2006): 447-456. (Review)

PMID
16724099
Full Text

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