Mary E Klotman, MD

Professor of Medicine
R.J. Reynolds Professor of Medicine
Dean, School of Medicine
Professor in Molecular Genetics and Microbiology
Professor of Pathology
Member of the Duke Human Vaccine Institute
Campus mail DUMC 2927, Davison Building Room 125, Durham, NC 27710
Phone (919) 684-2455
Email address mary.klotman@duke.edu

Dr. Klotman became dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

In Their Words

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
  • Resident, Medicine, Duke University, 1980 - 1983
  • M.D., Duke University, 1980

Publications

Tuyama, Ana C. G., Natalia Cheshenko, Maria J. Carlucci, Jin-Hua Li, Cindy L. Goldberg, Donald P. Waller, Robert A. Anderson, et al. “ACIDFORM inactivates herpes simplex virus and prevents genital herpes in a mouse model: optimal candidate for microbicide combinations..” J Infect Dis 194, no. 6 (September 15, 2006): 795–803. https://doi.org/10.1086/506948.

PMID
16941346
Full Text

Liu, Xinyan, Arevik Mosoian, Theresa Li-Yun Chang, Bouchra Zerhouni-Layachi, Alexandra Snyder, Gary A. Jarvis, and Mary E. Klotman. “Gonococcal lipooligosaccharide suppresses HIV infection in human primary macrophages through induction of innate immunity..” J Infect Dis 194, no. 6 (September 15, 2006): 751–59. https://doi.org/10.1086/506360.

PMID
16941340
Full Text

Mosoian, Arevik, Avelino Teixeira, Anthony A. High, Robert E. Christian, Donald F. Hunt, Jeffrey Shabanowitz, Xinyan Liu, and Mary Klotman. “Novel function of prothymosin alpha as a potent inhibitor of human immunodeficiency virus type 1 gene expression in primary macrophages..” J Virol 80, no. 18 (September 2006): 9200–9206. https://doi.org/10.1128/JVI.00589-06.

PMID
16940531
Full Text

Ross, Michael J., Cheng Fan, Michael D. Ross, Te-Huatearina Chu, Yueyue Shi, Lewis Kaufman, Weijia Zhang, Mary E. Klotman, and Paul E. Klotman. “HIV-1 infection initiates an inflammatory cascade in human renal tubular epithelial cells..” J Acquir Immune Defic Syndr 42, no. 1 (May 2006): 1–11. https://doi.org/10.1097/01.qai.0000218353.60099.4f.

PMID
16763488
Full Text

Ross, Michael J., Matthew S. Wosnitzer, Michael D. Ross, Benedetta Granelli, G Luca Gusella, Mohammad Husain, Lewis Kaufman, et al. “Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease..” J Am Soc Nephrol 17, no. 4 (April 2006): 996–1004. https://doi.org/10.1681/ASN.2005070692.

PMID
16495380
Full Text

Dhawan, Darpun, Marla Keller, and Mary E. Klotman. “Topical microbicides: the time has come..” Aids Read 16, no. 3 (March 2006): 144–61.

PMID
16538955
Scholars@Duke

Zerhouni-Layachi, Bouchra, Mohammad Husain, Michael J. Ross, Daniele Marras, Masaaki Sunamoto, Xinyan Liu, Paul E. Klotman, and Mary E. Klotman. “Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy..” Aids 20, no. 4 (February 28, 2006): 621–24. https://doi.org/10.1097/01.aids.0000210618.68083.8e.

PMID
16470129
Full Text

Wyatt, Christina M., Raymond R. Arons, Paul E. Klotman, and Mary E. Klotman. “Acute renal failure in hospitalized patients with HIV: risk factors and impact on in-hospital mortality..” Aids (London, England) 20, no. 4 (February 2006): 561–65. https://doi.org/10.1097/01.aids.0000210610.52836.07.

PMID
16470120
Full Text

Pages