Mary E Klotman, MD

Professor of Medicine
R.J. Reynolds Professor of Medicine
Dean, School of Medicine
Professor in Molecular Genetics and Microbiology
Professor of Pathology
Member of the Duke Human Vaccine Institute
Campus mail DUMC 2927, Davison Building Room 125, Durham, NC 27710
Phone (919) 684-2455
Email address mary.klotman@duke.edu

Dr. Klotman became dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

In Their Words

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
  • Resident, Medicine, Duke University, 1980 - 1983
  • M.D., Duke University, 1980

Publications

Kaufman, L, Yang, G, Hayashi, K, Ashby, JR, Huang, L, Ross, MJ, Klotman, ME, and Klotman, PE. "The homophilic adhesion molecule sidekick-1 contributes to augmented podocyte aggregation in HIV-associated nephropathy." FASEB J 21, no. 7 (May 2007): 1367-1375.

PMID
17307840
Full Text

Mosoian, A, Teixeira, A, Burns, CS, Khitrov, G, Zhang, W, Gusella, L, Klotman, P, and Klotman, M. "Influence of prothymosin-α on HIV-1 target cells." Annals of the New York Academy of Sciences 1112 (2007): 269-285.

PMID
17600282
Full Text

Bhadelia, N, Klotman, M, and Caplivski, D. "The HIV-Positive Traveler." American Journal of Medicine 120, no. 7 (2007): 574-580.

PMID
17602926
Full Text

Cara, A, and Klotman, ME. "Retroviral E-DNA: persistence and gene expression in nondividing immune cells." J Leukoc Biol 80, no. 5 (November 2006): 1013-1017. (Review)

PMID
16923918
Full Text

Tuyama, ACG, Cheshenko, N, Carlucci, MJ, Li, J-H, Goldberg, CL, Waller, DP, Anderson, RA, Profy, AT, Klotman, ME, Keller, MJ, and Herold, BC. "ACIDFORM inactivates herpes simplex virus and prevents genital herpes in a mouse model: optimal candidate for microbicide combinations." J Infect Dis 194, no. 6 (September 15, 2006): 795-803.

PMID
16941346
Full Text

Liu, X, Mosoian, A, Li-Yun Chang, T, Zerhouni-Layachi, B, Snyder, A, Jarvis, GA, and Klotman, ME. "Gonococcal lipooligosaccharide suppresses HIV infection in human primary macrophages through induction of innate immunity." J Infect Dis 194, no. 6 (September 15, 2006): 751-759.

PMID
16941340
Full Text

Klotman, ME, and Chang, TL. "Defensins in innate antiviral immunity." Nat Rev Immunol 6, no. 6 (June 2006): 447-456. (Review)

PMID
16724099
Full Text

Ross, MJ, Fan, C, Ross, MD, Chu, T-H, Shi, Y, Kaufman, L, Zhang, W, Klotman, ME, and Klotman, PE. "HIV-1 infection initiates an inflammatory cascade in human renal tubular epithelial cells." J Acquir Immune Defic Syndr 42, no. 1 (May 2006): 1-11.

PMID
16763488
Full Text

Ross, MJ, Wosnitzer, MS, Ross, MD, Granelli, B, Gusella, GL, Husain, M, Kaufman, L, Vasievich, M, D'Agati, VD, Wilson, PD, Klotman, ME, and Klotman, PE. "Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease." J Am Soc Nephrol 17, no. 4 (April 2006): 996-1004.

PMID
16495380
Full Text

Dhawan, D, Keller, M, and Klotman, ME. "Topical microbicides: the time has come." AIDS Read 16, no. 3 (March 2006): 144-161. (Review)

PMID
16538955
Scholars@Duke

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