Mary E Klotman, MD

Professor of Medicine
R.J. Reynolds Distinguished Professor of Medicine
Dean, School of Medicine
Professor in Molecular Genetics and Microbiology
Professor of Pathology
Member of the Duke Human Vaccine Institute
Campus mail DUMC 2927, Davison Building Room 125, Durham, NC 27710
Phone (919) 684-2455
Email address

Dr. Klotman became Dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

In Their Words

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
  • Resident, Medicine, Duke University, 1980 - 1983
  • M.D., Duke University, 1980


Kaufman, Lewis, Guozhe Yang, Kayo Hayashi, James R. Ashby, Li Huang, Michael J. Ross, Mary E. Klotman, and Paul E. Klotman. “The homophilic adhesion molecule sidekick-1 contributes to augmented podocyte aggregation in HIV-associated nephropathy.” Faseb J 21, no. 7 (May 2007): 1367–75.

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Cara, Andrea, and Mary E. Klotman. “Retroviral E-DNA: persistence and gene expression in nondividing immune cells.” J Leukoc Biol 80, no. 5 (November 2006): 1013–17.

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Tuyama, Ana C. G., Natalia Cheshenko, Maria J. Carlucci, Jin-Hua Li, Cindy L. Goldberg, Donald P. Waller, Robert A. Anderson, et al. “ACIDFORM inactivates herpes simplex virus and prevents genital herpes in a mouse model: optimal candidate for microbicide combinations.” J Infect Dis 194, no. 6 (September 15, 2006): 795–803.

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Liu, Xinyan, Arevik Mosoian, Theresa Li-Yun Chang, Bouchra Zerhouni-Layachi, Alexandra Snyder, Gary A. Jarvis, and Mary E. Klotman. “Gonococcal lipooligosaccharide suppresses HIV infection in human primary macrophages through induction of innate immunity.” J Infect Dis 194, no. 6 (September 15, 2006): 751–59.

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Mosoian, Arevik, Avelino Teixeira, Anthony A. High, Robert E. Christian, Donald F. Hunt, Jeffrey Shabanowitz, Xinyan Liu, and Mary Klotman. “Novel function of prothymosin alpha as a potent inhibitor of human immunodeficiency virus type 1 gene expression in primary macrophages.” J Virol 80, no. 18 (September 2006): 9200–9206.

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Ross, Michael J., Cheng Fan, Michael D. Ross, Te-Huatearina Chu, Yueyue Shi, Lewis Kaufman, Weijia Zhang, Mary E. Klotman, and Paul E. Klotman. “HIV-1 infection initiates an inflammatory cascade in human renal tubular epithelial cells.” J Acquir Immune Defic Syndr 42, no. 1 (May 2006): 1–11.

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Ross, Michael J., Matthew S. Wosnitzer, Michael D. Ross, Benedetta Granelli, G Luca Gusella, Mohammad Husain, Lewis Kaufman, et al. “Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease.” J Am Soc Nephrol 17, no. 4 (April 2006): 996–1004.

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Dhawan, Darpun, Marla Keller, and Mary E. Klotman. “Topical microbicides: the time has come.” Aids Read 16, no. 3 (March 2006): 144–61.