Mary E Klotman, MD

Professor of Medicine
R.J. Reynolds Professor of Medicine
Dean, School of Medicine
Professor in Molecular Genetics and Microbiology
Professor of Pathology
Member of the Duke Human Vaccine Institute
Campus mail DUMC 2927, Davison Building Room 125, Durham, NC 27710
Phone (919) 684-2455
Email address

Dr. Klotman became dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

In Their Words

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
  • Resident, Medicine, Duke University, 1980 - 1983
  • M.D., Duke University, 1980


Ross, Michael J., Matthew S. Wosnitzer, Michael D. Ross, Benedetta Granelli, G Luca Gusella, Mohammad Husain, Lewis Kaufman, et al. “Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease..” J Am Soc Nephrol 17, no. 4 (April 2006): 996–1004.

Full Text

Dhawan, Darpun, Marla Keller, and Mary E. Klotman. “Topical microbicides: the time has come..” The Aids Reader 16, no. 3 (March 2006): 144–57.


Zerhouni-Layachi, Bouchra, Mohammad Husain, Michael J. Ross, Daniele Marras, Masaaki Sunamoto, Xinyan Liu, Paul E. Klotman, and Mary E. Klotman. “Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy..” Aids (London, England) 20, no. 4 (February 2006): 621–24.

Full Text

Wyatt, Christina M., Raymond R. Arons, Paul E. Klotman, and Mary E. Klotman. “Acute renal failure in hospitalized patients with HIV: risk factors and impact on in-hospital mortality..” Aids (London, England) 20, no. 4 (February 2006): 561–65.

Full Text

Keller, Marla J., Bouchra Zerhouni-Layachi, Natalia Cheshenko, Minnie John, Kathleen Hogarty, Andrea Kasowitz, Cindy L. Goldberg, et al. “PRO 2000 gel inhibits HIV and herpes simplex virus infection following vaginal application: a double-blind placebo-controlled trial..” J Infect Dis 193, no. 1 (January 1, 2006): 27–35.

Full Text

John, Minnie, Marla J. Keller, Ehsan H. Fam, Natalia Cheshenko, Kathleen Hogarty, Andrea Kasowitz, Sylvan Wallenstein, et al. “Cervicovaginal secretions contribute to innate resistance to herpes simplex virus infection..” J Infect Dis 192, no. 10 (November 15, 2005): 1731–40.

Full Text

Husain, Mohammad, Vivette D. D’Agati, John Cijiang He, Mary E. Klotman, and Paul E. Klotman. “HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN..” Aids (London, England) 19, no. 17 (November 2005): 1975–80.

Full Text

Scordi-Bello, Irini A., Arevik Mosoian, Cejiang He, Yiban Chen, Yang Cheng, Gary A. Jarvis, Marla J. Keller, et al. “Candidate sulfonated and sulfated topical microbicides: comparison of anti-human immunodeficiency virus activities and mechanisms of action..” Antimicrob Agents Chemother 49, no. 9 (September 2005): 3607–15.

Full Text

Schwartz, Elissa J., Lynda A. Szczech, Michael J. Ross, Mary E. Klotman, Jonathan A. Winston, and Paul E. Klotman. “Highly active antiretroviral therapy and the epidemic of HIV+ end-stage renal disease..” J Am Soc Nephrol 16, no. 8 (August 2005): 2412–20.

Full Text