Mary E Klotman, MD

Professor of Medicine
R.J. Reynolds Professor of Medicine
Dean, School of Medicine
Professor in Molecular Genetics and Microbiology
Professor of Pathology
Member of the Duke Human Vaccine Institute
Campus mail DUMC 2927, Davison Building Room 125, Durham, NC 27710
Phone (919) 684-2455
Email address mary.klotman@duke.edu

Dr. Klotman became dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

In Their Words

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
  • Resident, Medicine, Duke University, 1980 - 1983
  • M.D., Duke University, 1980

Publications

Ross, MJ, Wosnitzer, MS, Ross, MD, Granelli, B, Gusella, GL, Husain, M, Kaufman, L, Vasievich, M, D'Agati, VD, Wilson, PD, Klotman, ME, and Klotman, PE. "Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease." Journal of the American Society of Nephrology : Jasn 17, no. 4 (April 2006): 996-1004.

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16495380
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Dhawan, D, Keller, M, and Klotman, ME. "Topical microbicides: the time has come." The Aids Reader 16, no. 3 (March 2006): 144-157. (Review)

PMID
16538955
Scholars@Duke

Fierer, DS, and Klotman, ME. "Kidney and central nervous system as reservoirs of HIV infection." Current Opinion in Hiv and Aids 1, no. 2 (March 2006): 115-120.

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19372794
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Zerhouni-Layachi, B, Husain, M, Ross, MJ, Marras, D, Sunamoto, M, Liu, X, Klotman, PE, and Klotman, ME. "Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy." Aids (London, England) 20, no. 4 (February 2006): 621-624.

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16470129
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Wyatt, CM, Arons, RR, Klotman, PE, and Klotman, ME. "Acute renal failure in hospitalized patients with HIV: risk factors and impact on in-hospital mortality." Aids (London, England) 20, no. 4 (February 2006): 561-565.

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16470120
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Keller, MJ, Zerhouni-Layachi, B, Cheshenko, N, John, M, Hogarty, K, Kasowitz, A, Goldberg, CL, Wallenstein, S, Profy, AT, Klotman, ME, and Herold, BC. "PRO 2000 gel inhibits HIV and herpes simplex virus infection following vaginal application: a double-blind placebo-controlled trial." The Journal of Infectious Diseases 193, no. 1 (January 2006): 27-35.

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16323128
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John, M, Keller, MJ, Fam, EH, Cheshenko, N, Hogarty, K, Kasowitz, A, Wallenstein, S, Carlucci, MJ, Tuyama, AC, Lu, W, Klotman, ME, Lehrer, RI, and Herold, BC. "Cervicovaginal secretions contribute to innate resistance to herpes simplex virus infection." The Journal of Infectious Diseases 192, no. 10 (November 2005): 1731-1740.

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16235171
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Husain, M, D'Agati, VD, He, JC, Klotman, ME, and Klotman, PE. "HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN." Aids (London, England) 19, no. 17 (November 2005): 1975-1980.

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16260903
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Scordi-Bello, IA, Mosoian, A, He, C, Chen, Y, Cheng, Y, Jarvis, GA, Keller, MJ, Hogarty, K, Waller, DP, Profy, AT, Herold, BC, and Klotman, ME. "Candidate sulfonated and sulfated topical microbicides: comparison of anti-human immunodeficiency virus activities and mechanisms of action." Antimicrobial Agents and Chemotherapy 49, no. 9 (September 2005): 3607-3615.

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16127029
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Schwartz, EJ, Szczech, LA, Ross, MJ, Klotman, ME, Winston, JA, and Klotman, PE. "Highly active antiretroviral therapy and the epidemic of HIV+ end-stage renal disease." Journal of the American Society of Nephrology : Jasn 16, no. 8 (August 2005): 2412-2420.

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15987747
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