Mary E Klotman, MD

Professor of Medicine
R.J. Reynolds Distinguished Professor of Medicine
Dean, School of Medicine
Professor in Molecular Genetics and Microbiology
Professor of Pathology
Member of the Duke Human Vaccine Institute
Campus mail DUMC 2927, Davison Building Room 125, Durham, NC 27710
Phone (919) 684-2455
Email address

Dr. Klotman became Dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

In Their Words

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
  • Resident, Medicine, Duke University, 1980 - 1983
  • M.D., Duke University, 1980


Cheshenko, Natalia, Marla J. Keller, Veronica MasCasullo, Gary A. Jarvis, Hui Cheng, Minnie John, Jin-Hua Li, et al. “Candidate topical microbicides bind herpes simplex virus glycoprotein B and prevent viral entry and cell-to-cell spread.” Antimicrob Agents Chemother 48, no. 6 (June 2004): 2025–36.

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Vargas, J., G. L. Gusella, V. Najfeld, M. E. Klotman, and A. Cara. “Novel integrase-defective lentiviral episomal vectors for gene transfer.” Hum Gene Ther 15, no. 4 (April 2004): 361–72.

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Zerhouni-Layachi, B., D. Marras, F. Francois, P. E. Klotman, and M. E. Klotman. “Phenotypic characterization of HIV-1 envelopes derived from patients with HIVAN.” In Journal of the American Society of Nephrology, 14:154A-154A. LIPPINCOTT WILLIAMS & WILKINS, 2003.


Ross, Michael D., Leslie A. Bruggeman, Basil Hanss, Masaaki Sunamoto, Daniele Marras, Mary E. Klotman, and Paul E. Klotman. “Podocan, a novel small leucine-rich repeat protein expressed in the sclerotic glomerular lesion of experimental HIV-associated nephropathy.” J Biol Chem 278, no. 35 (August 29, 2003): 33248–55.

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Chang, Theresa Li-Yun, Fleur François, Arevik Mosoian, and Mary E. Klotman. “CAF-mediated human immunodeficiency virus (HIV) type 1 transcriptional inhibition is distinct from alpha-defensin-1 HIV inhibition.” J Virol 77, no. 12 (June 2003): 6777–84.

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Keller, Marla J., Mary E. Klotman, and Betsy C. Herold. “Rigorous pre-clinical evaluation of topical microbicides to prevent transmission of human immunodeficiency virus.” J Antimicrob Chemother 51, no. 5 (May 2003): 1099–1102.

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Keller, M. J., M. E. Klotman, and B. C. Herold. “Development of topical microbicides for prevention of human immunodeficiency virus and herpes simplex virus.” Am J Reprod Immunol 49, no. 5 (May 2003): 279–84.

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Hernandez, Paolo A., Robert J. Gorlin, John N. Lukens, Shoichiro Taniuchi, Joze Bohinjec, Fleur Francois, Mary E. Klotman, and George A. Diaz. “Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease.” Nat Genet 34, no. 1 (May 2003): 70–74.

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François, Fleur, and Mary E. Klotman. “Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages.” J Virol 77, no. 4 (February 2003): 2539–49.

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