Mary E Klotman, MD

Professor of Medicine
R.J. Reynolds Professor of Medicine
Dean, School of Medicine
Professor in Molecular Genetics and Microbiology
Professor of Pathology
Member of the Duke Human Vaccine Institute
Campus mail DUMC 2927, Davison Building Room 125, Durham, NC 27710
Phone (919) 684-2455
Email address mary.klotman@duke.edu

Dr. Klotman became dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

In Their Words

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
  • Resident, Medicine, Duke University, 1980 - 1983
  • M.D., Duke University, 1980

Publications

Keller, M. J., M. E. Klotman, and B. C. Herold. “Development of topical microbicides for prevention of human immunodeficiency virus and herpes simplex virus..” American Journal of Reproductive Immunology (New York, N.Y. : 1989) 49, no. 5 (May 2003): 279–84. https://doi.org/10.1034/j.1600-0897.2003.00044.x.

PMID
12854732
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Hernandez, Paolo A., Robert J. Gorlin, John N. Lukens, Shoichiro Taniuchi, Joze Bohinjec, Fleur Francois, Mary E. Klotman, and George A. Diaz. “Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease..” Nat Genet 34, no. 1 (May 2003): 70–74. https://doi.org/10.1038/ng1149.

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12692554
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François, Fleur, and Mary E. Klotman. “Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages..” Journal of Virology 77, no. 4 (February 2003): 2539–49. https://doi.org/10.1128/JVI.77.4.2539-2549.2003.

PMID
12551992
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Herold, B. C., I. Scordi-Bello, N. Cheshenko, D. Marcellino, M. Dzuzelewski, F. Francois, R. Morin, et al. “Mandelic acid condensation polymer: novel candidate microbicide for prevention of human immunodeficiency virus and herpes simplex virus entry..” J Virol 76, no. 22 (November 2002): 11236–44. https://doi.org/10.1128/jvi.76.22.11236-11244.2002.

PMID
12388683
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Husain, Mohammad, G Luca Gusella, Mary E. Klotman, Irwin H. Gelman, Michael D. Ross, Elissa J. Schwartz, Andrea Cara, and Paul E. Klotman. “HIV-1 Nef induces proliferation and anchorage-independent growth in podocytes..” J Am Soc Nephrol 13, no. 7 (July 2002): 1806–15. https://doi.org/10.1097/01.asn.0000019642.55998.69.

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12089376
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Schwartz, Elissa J., Daniel S. Fierer, Avidan U. Neumann, Marla J. Keller, Valerie Parkas, David Y. Zhang, Mary E. Klotman, Jonathan A. Winston, and Paul E. Klotman. “HIV-1 dynamics in haemodialysis patients..” Aids 16, no. 9 (June 14, 2002): 1301–3. https://doi.org/10.1097/00002030-200206140-00019.

PMID
12045502
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Klotman, Paul, and Mary Klotman. “Editorial comment: renal insufficiency in HIV-infected patients may not always be HIVAN..” Aids Read 12, no. 6 (June 2002).

PMID
12138882
Scholars@Duke

Marras, Daniele, Leslie A. Bruggeman, Feng Gao, Nozomu Tanji, Mahesh M. Mansukhani, Andrea Cara, Michael D. Ross, et al. “Replication and compartmentalization of HIV-1 in kidney epithelium of patients with HIV-associated nephropathy..” Nat Med 8, no. 5 (May 2002): 522–26. https://doi.org/10.1038/nm0502-522.

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11984599
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Gusella, G Luca, Elena Fedorova, Basil Hanss, Daniele Marras, Mary E. Klotman, and Paul E. Klotman. “Lentiviral gene transduction of kidney..” Hum Gene Ther 13, no. 3 (February 10, 2002): 407–14. https://doi.org/10.1089/10430340252792530.

PMID
11860707
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Cara, A., J. Vargas, M. Keller, S. Jones, A. Mosoian, A. Gurtman, A. Cohen, et al. “Circular viral DNA and anomalous junction sequence in PBMC of HIV-infected individuals with no detectable plasma HIV RNA..” In Virology, 292:1–5, 2002. https://doi.org/10.1006/viro.2001.1243.

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11878902
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