Mary E Klotman, MD

Professor of Medicine
R.J. Reynolds Professor of Medicine
Dean, School of Medicine
Professor in Molecular Genetics and Microbiology
Professor of Pathology
Member of the Duke Human Vaccine Institute
Campus mail DUMC 2927, Davison Building Room 125, Durham, NC 27710
Phone (919) 684-2455
Email address mary.klotman@duke.edu

Dr. Klotman became dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

In Their Words

Education and Training

  • Fellow in Infectious Diseases, Medicine, Duke University, 1983 - 1985
  • Resident, Medicine, Duke University, 1980 - 1983
  • M.D., Duke University, 1980

Publications

Winston, JA, Klotman, PE, and Klotman, M. "Renal Manifestations of HIV Infection." (April 8, 2004): 651-661. (Chapter)

Full Text

Vargas, J, Gusella, GL, Najfeld, V, Klotman, ME, and Cara, A. "Novel integrase-defective lentiviral episomal vectors for gene transfer." Human Gene Therapy 15, no. 4 (April 2004): 361-372.

PMID
15053861
Full Text

Zerhouni-Layachi, B, Marras, D, Francois, F, Klotman, PE, and Klotman, ME. "Phenotypic characterization of HIV-1 envelopes derived from patients with HIVAN." 36th Annual Meeting of the American-Society-of-Nephrology. SAN DIEGO, CALIFORNIA. November 12, 2003 - November 17, 2003.: LIPPINCOTT WILLIAMS & WILKINS, November 1, 2003.

Scholars@Duke

Ross, MD, Bruggeman, LA, Hanss, B, Sunamoto, M, Marras, D, Klotman, ME, and Klotman, PE. "Podocan, a novel small leucine-rich repeat protein expressed in the sclerotic glomerular lesion of experimental HIV-associated nephropathy." The Journal of Biological Chemistry 278, no. 35 (August 2003): 33248-33255.

PMID
12796502
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Chang, TL-Y, François, F, Mosoian, A, and Klotman, ME. "CAF-mediated human immunodeficiency virus (HIV) type 1 transcriptional inhibition is distinct from alpha-defensin-1 HIV inhibition." Journal of Virology 77, no. 12 (June 2003): 6777-6784.

PMID
12767998
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Keller, MJ, Klotman, ME, and Herold, BC. "Rigorous pre-clinical evaluation of topical microbicides to prevent transmission of human immunodeficiency virus." The Journal of Antimicrobial Chemotherapy 51, no. 5 (May 2003): 1099-1102. (Review)

PMID
12697652
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Keller, MJ, Klotman, ME, and Herold, BC. "Development of topical microbicides for prevention of human immunodeficiency virus and herpes simplex virus." American Journal of Reproductive Immunology (New York, N.Y. : 1989) 49, no. 5 (May 2003): 279-284. (Review)

PMID
12854732
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Hernandez, PA, Gorlin, RJ, Lukens, JN, Taniuchi, S, Bohinjec, J, Francois, F, Klotman, ME, and Diaz, GA. "Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease." Nature Genetics 34, no. 1 (May 2003): 70-74.

PMID
12692554
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François, F, and Klotman, ME. "Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages." Journal of Virology 77, no. 4 (February 2003): 2539-2549.

PMID
12551992
Full Text

Herold, BC, Scordi-Bello, I, Cheshenko, N, Marcellino, D, Dzuzelewski, M, Francois, F, Morin, R, Casullo, VM, Anderson, RA, Chany, C, Waller, DP, Zaneveld, LJD, and Klotman, ME. "Mandelic acid condensation polymer: novel candidate microbicide for prevention of human immunodeficiency virus and herpes simplex virus entry." Journal of Virology 76, no. 22 (November 2002): 11236-11244.

PMID
12388683
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