Mary Elizabeth Anne Sunday, MD, PhD

Professor of Pathology
Professor in Cell Biology
Professor of Medicine
Professor in Pediatrics
Campus mail Davison Bldg., 2nd Floor, Durham, NC 27710
Phone (919) 681-4945
Email address mary.sunday@duke.edu

Oxygen (O2) is essential for life, but excessive oxygen causes tissue injury, scarring, aging, and death. We are studying mechanisms of injury mediated by O2-sensing pulmonary neuroendocrine cells, especially gastrin-releasing peptide (GRP). GRP secretion is induced by O2-related (oxidant) injury, leading to acute and chronic lung injury and pulmonary fibrosis (PF). Our key model is PF due to ionizing radiation to the thorax. This is clinically relevant to PF triggered by many environmental exposures or autoimmune diseases, as well as idiopathic pulmonary fibrosis (IPF). There is no cure for PF. We seek to reverse fibrotic responses in lung.

Education and Training

  • Research Fellow, Pathology, Children's Hospital, Boston, 1986 - 1987
  • Research & Clinical Fellow, Pathology, Madigan Army Medical Center, 1985 - 1987
  • Research Fellow, Medicine, Massachusetts General Hospital, 1983 - 1987
  • Resident, Anatomic Pathology, Pathology, Madigan Army Medical Center, 1983 - 1985
  • Intern, Internal Medicine, Johns Hopkins University, 1982 - 1983
  • Ph.D., Harvard University , 1982
  • M.D., Harvard University , 1982
  • B.S., University of Toronto (Canada), 1976

Publications

Sunday, M. E., J. Hua, J. S. Torday, B. Reyes, and M. A. Shipp. “CD10/neutral endopeptidase 24.11 in developing human fetal lung. Patterns of expression and modulation of peptide-mediated proliferation.” J Clin Invest 90, no. 6 (December 1992): 2517–25. https://doi.org/10.1172/JCI116145.

PMID
1469102
Full Text

Aguayo, S. M., Y. E. Miller, J. A. Waldron, R. M. Bogin, M. E. Sunday, G. W. Staton, W. R. Beam, and T. E. King. “Brief report: idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells and airways disease.” N Engl J Med 327, no. 18 (October 29, 1992): 1285–88. https://doi.org/10.1056/NEJM199210293271806.

PMID
1406819
Full Text

Sunday, M. E., and C. G. Willett. “Induction and spontaneous regression of intense pulmonary neuroendocrine cell differentiation in a model of preneoplastic lung injury.” Cancer Res 52, no. 9 Suppl (May 1, 1992): 2677s-2686s.

PMID
1314133
Scholars@Duke

Yen, P. M., M. E. Sunday, D. S. Darling, and W. W. Chin. “Isoform-specific thyroid hormone receptor antibodies detect multiple thyroid hormone receptors in rat and human pituitaries.” Endocrinology 130, no. 3 (March 1992): 1539–46. https://doi.org/10.1210/endo.130.3.1537303.

PMID
1537303
Full Text

Sunday, M. E., and C. G. Willett. “Induction and spontaneous regression of intense pulmonary neuroendocrine cell differentiation in a model of preneoplastic lung injury.” Cancer Research 52, no. 9 SUPPL. (January 1, 1992).

Scholars@Duke

Sunday, M. E., and C. G. Willett. “Induction and spontaneous regression of pulmonary neuroendocrine cell hyperplasia in a hamster model.” Chest 101, no. 3 SUPPL. (January 1, 1992).

Scholars@Duke

Shipp, M. A., G. E. Tarr, C. Y. Chen, S. N. Switzer, L. B. Hersh, H. Stein, M. E. Sunday, and E. L. Reinherz. “CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung.” Proc Natl Acad Sci U S A 88, no. 23 (December 1, 1991): 10662–66. https://doi.org/10.1073/pnas.88.23.10662.

PMID
1660144
Full Text

Sunday, M. E., N. Choi, E. R. Spindel, W. W. Chin, and E. J. Mark. “Gastrin-releasing peptide gene expression in small cell and large cell undifferentiated lung carcinomas.” Hum Pathol 22, no. 10 (October 1991): 1030–39. https://doi.org/10.1016/0046-8177(91)90011-d.

PMID
1668786
Full Text

Rollins, B. J., and M. E. Sunday. “Suppression of tumor formation in vivo by expression of the JE gene in malignant cells.” Mol Cell Biol 11, no. 6 (June 1991): 3125–31. https://doi.org/10.1128/mcb.11.6.3125.

PMID
2038321
Full Text

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