Mary Elizabeth Anne Sunday, MD, PhD

Professor of Pathology
Professor in Cell Biology
Professor of Medicine
Professor in Pediatrics
Member of the Duke Cancer Institute
Campus mail Davison Bldg., 2nd Floor, Durham, NC 27710
Phone (919) 681-4945
Email address mary.sunday@duke.edu

Oxygen (O2) is essential for life, but excessive oxygen causes tissue injury, scarring, aging, and death. We are studying mechanisms of injury mediated by O2-sensing pulmonary neuroendocrine cells, especially gastrin-releasing peptide (GRP). GRP secretion is induced by O2-related (oxidant) injury, leading to acute and chronic lung injury and pulmonary fibrosis (PF). Our key model is PF due to ionizing radiation to the thorax. This is clinically relevant to PF triggered by many environmental exposures or autoimmune diseases, as well as idiopathic pulmonary fibrosis (IPF). There is no cure for PF. We seek to reverse fibrotic responses in lung.

Education and Training

  • Research Fellow, Pathology, Children's Hospital Boston, 1986 - 1987
  • Research & Clinical Fellow, Pathology, Madigan Army Medical Center, 1985 - 1987
  • Research Fellow, Medicine, Massachusetts General Hospital, 1983 - 1987
  • Resident, Anatomic Pathology, Pathology, Madigan Army Medical Center, 1983 - 1985
  • Intern, Internal Medicine, Johns Hopkins University, 1982 - 1983
  • Ph.D., Harvard University , 1982
  • M.D., Harvard University , 1982
  • B.S., University of Toronto (Canada), 1976

Publications

Ng, Y. -. S., R. Rohan, M. E. Sunday, D. E. Demello, and P. A. D’Amore. “Differential expression of VEGF isoforms in mouse during development and in the adult.” Developmental Dynamics 220, no. 2 (February 1, 2001): 112–21. https://doi.org/10.1002/1097-0177(2000)9999:9999<::aid-dvdy1093>3.0.co;2-d.

Full Text

Ng, Y. -. S., R. Rohan, M. E. Sunday, D. E. Demello, and P. A. D’Amore. “Differential expression of VEGF isoforms in mouse during development and in the adult.” Developmental Dynamics 220, no. 2 (February 1, 2001): 112–21. https://doi.org/10.1002/1097-0177(2000)9999:9999<::aid-dvdy1093>3.0.co;2-d.

Full Text

Ng, Y. S., R. Rohan, M. E. Sunday, D. E. Demello, and P. A. D’Amore. “Differential expression of VEGF isoforms in mouse during development and in the adult..” Developmental Dynamics : An Official Publication of the American Association of Anatomists 220, no. 2 (February 2001): 112–21. https://doi.org/10.1002/1097-0177(2000)9999:9999&lt;::aid-dvdy1093&gt;3.0.co;2-d.

PMID
11169844
Full Text

Wu, E., B. P. Mari, F. Wang, I. C. Anderson, M. E. Sunday, and M. A. Shipp. “Stromelysin-3 suppresses tumor cell apoptosis in a murine model..” J Cell Biochem 82, no. 4 (2001): 549–55.

PMID
11500932
Scholars@Duke

Emanuel, R. L., J. S. Torday, N. Asokananthan, and M. E. Sunday. “Direct effects of corticotropin-releasing hormone and thyrotropin-releasing hormone on fetal lung explants.” Peptides 22, no. 12 (2001): 1819–29.

Scholars@Duke

Emanuel, R. L., J. S. Torday, N. Asokananthan, and M. E. Sunday. “Direct effects of corticotropin-releasing hormone and thyrotropin-releasing hormone on fetal lung explants..” Peptides 21, no. 12 (December 2000): 1819–29.

PMID
11150642
Scholars@Duke

Cullen, A., R. L. Emanuel, J. S. Torday, N. Asokananthan, K. A. Sikorski, and M. E. Sunday. “Bombesin-like peptide and receptors in lung injury models: diverse gene expression, similar function..” Peptides 21, no. 11 (November 2000): 1627–38.

PMID
11090916
Scholars@Duke

Emanuel, R. L., J. S. Torday, Q. Mu, N. Asokananthan, K. A. Sikorski, and M. E. Sunday. “Bombesin-like peptides and receptors in normal fetal baboon lung: roles in lung growth and maturation..” The American Journal of Physiology 277, no. 5 (November 1999): L1003–17. https://doi.org/10.1152/ajplung.1999.277.5.l1003.

PMID
10564187
Full Text

Brimhall, B. B., K. A. Sikorski, J. Torday, A. Shahsafaei, K. J. Haley, and M. E. Sunday. “Syntaxin 1A is transiently expressed in fetal lung mesenchymal cells: Potential developmental roles.” American Journal of Physiology  Lung Cellular and Molecular Physiology 277, no. 2 21-2 (August 1, 1999).

Scholars@Duke

Brimhall, B. B., K. A. Sikorski, J. Torday, A. Shahsafaei, K. J. Haley, and M. E. Sunday. “Syntaxin 1A is transiently expressed in fetal lung mesenchymal cells: potential developmental roles..” The American Journal of Physiology 277, no. 2 (August 1999): L401–11. https://doi.org/10.1152/ajplung.1999.277.2.l401.

PMID
10444535
Full Text

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