Mary Elizabeth Anne Sunday, MD, PhD

Professor of Pathology
Professor in Cell Biology
Professor of Medicine
Professor in Pediatrics
Member of the Duke Cancer Institute
Campus mail Davison Bldg., 2nd Floor, Durham, NC 27710
Phone (919) 681-4945
Email address mary.sunday@duke.edu

Oxygen (O2) is essential for life, but excessive oxygen causes tissue injury, scarring, aging, and death. We are studying mechanisms of injury mediated by O2-sensing pulmonary neuroendocrine cells, especially gastrin-releasing peptide (GRP). GRP secretion is induced by O2-related (oxidant) injury, leading to acute and chronic lung injury and pulmonary fibrosis (PF). Our key model is PF due to ionizing radiation to the thorax. This is clinically relevant to PF triggered by many environmental exposures or autoimmune diseases, as well as idiopathic pulmonary fibrosis (IPF). There is no cure for PF. We seek to reverse fibrotic responses in lung.

Education and Training

  • Research Fellow, Pathology, Children's Hospital Boston, 1986 - 1987
  • Research & Clinical Fellow, Pathology, Madigan Army Medical Center, 1985 - 1987
  • Research Fellow, Medicine, Massachusetts General Hospital, 1983 - 1987
  • Resident, Anatomic Pathology, Pathology, Madigan Army Medical Center, 1983 - 1985
  • Intern, Internal Medicine, Johns Hopkins University, 1982 - 1983
  • Ph.D., Harvard University , 1982
  • M.D., Harvard University , 1982
  • B.S., University of Toronto (Canada), 1976

Publications

Sunday, ME, Haley, KJ, Sikorski, K, Graham, SA, Emanuel, RL, Zhang, F, Mu, Q, Shahsafaei, A, and Hatzis, D. "Calcitonin driven v-Ha-ras induces multilineage pulmonary epithelial hyperplasias and neoplasms." Oncogene 18, no. 30 (July 29, 1999): 4336-4347.

PMID
10439041
Full Text

Willett, CG, Shahsafei, A, Graham, SA, and Sunday, ME. "CD10/neutral endopeptidase inhibition augments pulmonary neuroendocrine cell hyperplasia in hamsters treated with diethylnitrosamine and hyperoxia." Am J Respir Cell Mol Biol 21, no. 1 (July 1999): 13-20.

PMID
10385588
Full Text

Muglia, LJ, Bae, DS, Brown, TT, Vogt, SK, Alvarez, JG, Sunday, ME, and Majzoub, JA. "Proliferation and differentiation defects during lung development in corticotropin-releasing hormone-deficient mice." Am J Respir Cell Mol Biol 20, no. 2 (February 1999): 181-188.

PMID
9922208
Full Text

Emanuel, RL, Torday, JS, Mu, Q, Asokananthan, N, Sikorski, KA, and Sunday, ME. "Bombesin-like peptides and receptors in normal fetal baboon lung: Roles in lung growth and maturation." American Journal of Physiology Lung Cellular and Molecular Physiology 277, no. 5 21-5 (January 1, 1999).

Scholars@Duke

Kinane, TB, Komatsuzaki, K, Aleixo, MD, Sunday, ME, and Ercolani, L. "Regulation of the G protein Galphai2 by growth and development in fetal airway epithelium." Am J Respir Cell Mol Biol 20, no. 1 (January 1999): 35-42.

PMID
9870915
Full Text

Sunday, ME, Yoder, BA, Cuttitta, F, Haley, KJ, and Emanuel, RL. "Bombesin-like peptide mediates lung injury in a baboon model of bronchopulmonary dysplasia." J Clin Invest 102, no. 3 (August 1, 1998): 584-594.

PMID
9691095
Full Text

Haley, KJ, Patidar, K, Zhang, F, Emanuel, RL, and Sunday, ME. "Tumor necrosis factor induces neuroendocrine differentiation in small cell lung cancer cell lines." The American Journal of Physiology 275, no. 2 (August 1998): L311-L321.

PMID
9700092
Full Text

Haley, KJ, Sunday, ME, Wiggs, BR, Kozakewich, HP, Reilly, JJ, Mentzer, SJ, Sugarbaker, DJ, Doerschuk, CM, and Drazen, JM. "Inflammatory cell distribution within and along asthmatic airways." Am J Respir Crit Care Med 158, no. 2 (August 1998): 565-572.

PMID
9700136
Full Text

Willett, CG, Wang, MH, Emanuel, RL, Graham, SA, Smith, DI, Shridhar, V, Sugarbaker, DJ, and Sunday, ME. "Macrophage-stimulating protein and its receptor in non-small-cell lung tumors: induction of receptor tyrosine phosphorylation and cell migration." Am J Respir Cell Mol Biol 18, no. 4 (April 1998): 489-496.

PMID
9533936
Full Text

Johnston, D, Hatzis, D, and Sunday, ME. "Expression of v-Ha-ras driven by the calcitonin/calcitonin gene-related peptide promoter: a novel transgenic murine model for medullary thyroid carcinoma." Oncogene 16, no. 2 (January 15, 1998): 167-177.

PMID
9464534
Full Text

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