Mary Elizabeth Anne Sunday, MD, PhD

Professor of Pathology
Professor in Cell Biology
Professor of Medicine
Professor in Pediatrics
Campus mail Davison Bldg., 2nd Floor, Durham, NC 27710
Phone (919) 681-4945
Email address mary.sunday@duke.edu

Oxygen (O2) is essential for life, but excessive oxygen causes tissue injury, scarring, aging, and death. We are studying mechanisms of injury mediated by O2-sensing pulmonary neuroendocrine cells, especially gastrin-releasing peptide (GRP). GRP secretion is induced by O2-related (oxidant) injury, leading to acute and chronic lung injury and pulmonary fibrosis (PF). Our key model is PF due to ionizing radiation to the thorax. This is clinically relevant to PF triggered by many environmental exposures or autoimmune diseases, as well as idiopathic pulmonary fibrosis (IPF). There is no cure for PF. We seek to reverse fibrotic responses in lung.

Education and Training

  • Research Fellow, Pathology, Children's Hospital, Boston, 1986 - 1987
  • Research & Clinical Fellow, Pathology, Madigan Army Medical Center, 1985 - 1987
  • Research Fellow, Medicine, Massachusetts General Hospital, 1983 - 1987
  • Resident, Anatomic Pathology, Pathology, Madigan Army Medical Center, 1983 - 1985
  • Intern, Internal Medicine, Johns Hopkins University, 1982 - 1983
  • Ph.D., Harvard University , 1982
  • M.D., Harvard University , 1982
  • B.S., University of Toronto (Canada), 1976

Publications

Lawler, J., M. Sunday, V. Thibert, M. Duquette, E. L. George, H. Rayburn, and R. O. Hynes. “Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia..” J Clin Invest 101, no. 5 (March 1, 1998): 982–92. https://doi.org/10.1172/JCI1684.

PMID
9486968
Full Text

Johnston, D., D. Hatzis, and M. E. Sunday. “Expression of v-Ha-ras driven by the calcitonin/calcitonin gene-related peptide promoter: a novel transgenic murine model for medullary thyroid carcinoma..” Oncogene 16, no. 2 (January 15, 1998): 167–77. https://doi.org/10.1038/sj.onc.1201478.

PMID
9464534
Full Text

Wada, E., K. Watase, K. Yamada, H. Ogura, M. Yamano, Y. Inomata, J. Eguchi, et al. “Generation and characterization of mice lacking gastrin-releasing peptide receptor..” Biochem Biophys Res Commun 239, no. 1 (October 9, 1997): 28–33. https://doi.org/10.1006/bbrc.1997.7418.

PMID
9345264
Full Text

Willett, C. G., D. I. Smith, V. Shridhar, M. H. Wang, R. L. Emanuel, K. Patidar, S. A. Graham, et al. “Differential screening of a human chromosome 3 library identifies hepatocyte growth factor-like/macrophage-stimulating protein and its receptor in injured lung. Possible implications for neuroendocrine cell survival..” J Clin Invest 99, no. 12 (June 15, 1997): 2979–91. https://doi.org/10.1172/JCI119493.

PMID
9185522
Full Text

Haley, K. J., J. M. Drazen, R. Osathanondh, and M. E. Sunday. “Comparison of the ontogeny of protein gene product 9.5, chromogranin A and proliferating cell nuclear antigen in developing human lung.” Microscopy Research and Technique 37, no. 1 (April 1, 1997): 62–68. https://doi.org/10.1002/(SICI)1097-0029(19970401)37:1<62::AID-JEMT6>3.0.CO;2-Y.

Full Text

Haley, K. J., J. M. Drazen, R. Osathanondh, and M. E. Sunday. “Comparison of the ontogeny of protein gene product 9.5, chromogranin A and proliferating cell nuclear antigen in developing human lung..” Microsc Res Tech 37, no. 1 (April 1, 1997): 62–68. https://doi.org/10.1002/(SICI)1097-0029(19970401)37:1<62::AID-JEMT6>3.0.CO;2-Y.

PMID
9144622
Full Text

Haley, K. J., J. M. Drazen, R. Osathanondh, and M. E. Sunday. “Comparison of the ontogeny of protein gene product 9.5, chromogranin A and proliferating cell nuclear antigen in developing human lung..” Microscopy Research and Technique 37, no. 1 (April 1997): 62–68. https://doi.org/10.1002/(SICI)1097-0029(19970401)37:13.0.CO;2.

Full Text

Sunday, M. E., Q. Mu, M. Fishman, and D. Hatzis. “Neuroendocrine (ne) cell hyperplasia and non-ne tumors in transgenic mice with v-ha-ras driven by the calcitonin promoter.” Faseb Journal 10, no. 6 (December 1, 1996).

Scholars@Duke

Huang, M. H., D. S. Friend, M. E. Sunday, K. Singh, K. Haley, K. F. Austen, R. A. Kelly, and T. W. Smith. “An intrinsic adrenergic system in mammalian heart..” J Clin Invest 98, no. 6 (September 15, 1996): 1298–1303. https://doi.org/10.1172/JCI118916.

PMID
8823294
Full Text

Wuenschell, C. W., M. E. Sunday, G. Singh, P. Minoo, H. C. Slavkin, and D. Warburton. “Embryonic mouse lung epithelial progenitor cells co-express immunohistochemical markers of diverse mature cell lineages..” J Histochem Cytochem 44, no. 2 (February 1996): 113–23. https://doi.org/10.1177/44.2.8609367.

PMID
8609367
Full Text

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