Mary Elizabeth Anne Sunday, MD, PhD

Professor of Pathology
Professor in Cell Biology
Professor of Medicine
Professor in Pediatrics
Member of the Duke Cancer Institute
Campus mail Davison Bldg., 2nd Floor, Durham, NC 27710
Phone (919) 681-4945
Email address mary.sunday@duke.edu

Oxygen (O2) is essential for life, but excessive oxygen causes tissue injury, scarring, aging, and death. We are studying mechanisms of injury mediated by O2-sensing pulmonary neuroendocrine cells, especially gastrin-releasing peptide (GRP). GRP secretion is induced by O2-related (oxidant) injury, leading to acute and chronic lung injury and pulmonary fibrosis (PF). Our key model is PF due to ionizing radiation to the thorax. This is clinically relevant to PF triggered by many environmental exposures or autoimmune diseases, as well as idiopathic pulmonary fibrosis (IPF). There is no cure for PF. We seek to reverse fibrotic responses in lung.

Education and Training

  • Research Fellow, Pathology, Children's Hospital Boston, 1986 - 1987
  • Research & Clinical Fellow, Pathology, Madigan Army Medical Center, 1985 - 1987
  • Research Fellow, Medicine, Massachusetts General Hospital, 1983 - 1987
  • Resident, Anatomic Pathology, Pathology, Madigan Army Medical Center, 1983 - 1985
  • Intern, Internal Medicine, Johns Hopkins University, 1982 - 1983
  • Ph.D., Harvard University , 1982
  • M.D., Harvard University , 1982
  • B.S., University of Toronto (Canada), 1976

Publications

Haley, KJ, Patidar, K, Zhang, F, Emanuel, RL, and Sunday, ME. "Tumor necrosis factor induces neuroendocrine differentiation in small cell lung cancer cell lines." American Journal of Physiology - Lung Cellular and Molecular Physiology 275, no. 2 19-2 (1998): L311-L321.

Scholars@Duke

Lawler, J, Sunday, M, Thibert, V, Duquette, M, George, EL, Rayburn, H, and Hynes, RO. "Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia." Journal of Clinical Investigation 101, no. 5 (1998): 982-992.

PMID
9486968
Full Text

Montuenga, LM, Zhou, J, Avis, I, Vos, M, Martinez, A, Cuttitta, F, Treston, AM, Sunday, M, and Mulshine, JL. "Expression of heterogeneous nuclear ribonucleoprotein A2/B1 changes with critical stages of mammalian lung development." American Journal of Respiratory Cell and Molecular Biology 19, no. 4 (1998): 554-562.

PMID
9761751
Scholars@Duke

Wada, E, Watase, K, Yamada, K, Ogura, H, Yamano, M, Inomata, Y, Eguchi, J, Yamamoto, K, Sunday, ME, Maeno, H, Mikoshiba, K, Ohki-Hamazaki, H, and Wada, K. "Generation and characterization of mice lacking gastrin-releasing peptide receptor." Biochemical and Biophysical Research Communications 239, no. 1 (October 1997): 28-33.

PMID
9345264
Full Text

Willett, CG, Smith, DI, Shridhar, V, Wang, MH, Emanuel, RL, Patidar, K, Graham, SA, Zhang, F, Hatch, V, Sugarbaker, DJ, and Sunday, ME. "Differential screening of a human chromosome 3 library identifies hepatocyte growth factor-like/macrophage-stimulating protein and its receptor in injured lung. Possible implications for neuroendocrine cell survival." J Clin Invest 99, no. 12 (June 15, 1997): 2979-2991.

PMID
9185522
Full Text

Haley, KJ, Drazen, JM, Osathanondh, R, and Sunday, ME. "Comparison of the ontogeny of protein gene product 9.5, chromogranin A and proliferating cell nuclear antigen in developing human lung." Microscopy Research and Technique 37, no. 1 (April 1997): 62-68.

PMID
9144622
Full Text

Haley, KJ, Drazen, JM, Osathanondh, R, and Sunday, ME. "Comparison of the ontogeny of protein gene product 9.5, chromogranin A and proliferating cell nuclear antigen in developing human lung." Microscopy Research and Technique 37, no. 1 (April 1, 1997): 62-68.

Full Text

Haley, KJ, Drazen, JM, Osathanondh, R, and Sunday, ME. "Comparison of the ontogeny of protein gene product 9.5, chromogranin A and proliferating cell nuclear antigen in developing human lung." Microscopy research and technique 37, no. 1 (April 1997): 62-68. (Academic Article)

Full Text

Sunday, ME, Mu, Q, Fishman, M, and Hatzis, D. "Neuroendocrine (ne) cell hyperplasia and non-ne tumors in transgenic mice with v-ha-ras driven by the calcitonin promoter." Faseb Journal 10, no. 6 (December 1, 1996).

Scholars@Duke

Huang, MH, Friend, DS, Sunday, ME, Singh, K, Haley, K, Austen, KF, Kelly, RA, and Smith, TW. "An intrinsic adrenergic system in mammalian heart." J Clin Invest 98, no. 6 (September 15, 1996): 1298-1303.

PMID
8823294
Full Text

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