Matthew A. Sparks, MD

Assistant Professor of Medicine
Campus mail 2 Genome Court, Msrb2 Room 1013, Box_103015, Durham, NC 27710
Phone (919) 684-9737
Email address matthew.sparks@duke.edu

My lab is interested in understanding how both the renin angiotensin and prostanoid systems regulate blood pressure by altering blood flow to the kidney. My lab utilizes a combination of physiologic and molecular techniques in genetically modified mice to probe questions about how changes in the micro circulation in the kidney alter sodium excretion. The overarching goal of this research is to identify novel mechanisms to target drug therapy for patients with hypertension. My research is funded by a career development award from the Department of Veterans Affairs Office of Research and Development (IK2BX002240) and a Scientist Development Grant from the American Heart Association. In my role as Director of Undergraduate Medical Research in the Department of Medicine I help promote research in the Department of Medicine during the 3rd year of medical school at Duke University. I also serve as the Associate Program Director for the Nephrology Fellowship Program.

I'm also interested finding ways to promote medical education. My focus is on leveraging social media to enhance learning in nephrology. I am a faculty member of the Nephrology Social Media Collective (NSMC) and member of the online nephrology journal club (NephJC). I am also co-founder and advisory board member of the first nephrology blog associated with a journal- AJKD blog, the official blog of the American Journal of Kidney Diseases. Co-creator of the popular edutainment project NephMadness. Past deputy editor of Renal Fellow Network where I continue to remain an advocate for the site and author the yearly “Top Nephrology Stories of the Year”. I am currently a member of the Communications and Media Committee of the American Society of Nephrology, the American Heart Association and am a fellow of the American Society of Nephrology and the National Kidney Foundation.

I serve as Education Director for KIDNEYcon- a yearly hands-on conference dedicated to advances in nephrology held in Little Rock, AR each April.

@Nephro_Sparks on Twitter

Nephrology Fellowship Program

Education and Training

  • Fellow in Nephrology, Medicine, Duke University School of Medicine, 2007 - 2011
  • Chief Resident, Medicine, University of Arkansas for Medical Sciences College of Medicine, 2006 - 2007
  • Resident, Medicine, University of Arkansas for Medical Sciences College of Medicine, 2003 - 2006
  • M.D., University of Arkansas for Medical Sciences College of Medicine, 2003

Publications

Zhang, J, Patel, MB, Griffiths, R, Mao, A, Song, Y-S, Karlovich, NS, Sparks, MA, Jin, H, Wu, M, Lin, EE, and Crowley, SD. "Tumor necrosis factor-α produced in the kidney contributes to angiotensin II-dependent hypertension." Hypertension (2014).

Full Text

Xie, L, Sparks, MA, Li, W, Qi, Y, Liu, C, Coffman, TM, and Johnson, GA. "Quantitative susceptibility mapping of kidney inflammation and fibrosis in type 1 angiotensin receptor-deficient mice." NMR Biomed 26, no. 12 (December 2013): 1853-1863.

PMID
24154952
Full Text

Malone, AF, Sparks, MA, Howell, DN, Middleton, JP, Smith, SR, and Lehrich, RW. "IgG4-related tubulointerstitial nephritis associated with chronic lymphocytic leukemia." J Nephrol 26, no. 6 (November 2013): 1195-1198.

PMID
24284523
Full Text

Jhaveri, KD, Sparks, MA, and Shah, HH. "Novel educational approaches to enhance learning and interest in nephrology." Adv Chronic Kidney Dis 20, no. 4 (July 2013): 336-346. (Review)

PMID
23809286
Full Text

Pippin, JW, Sparks, MA, Glenn, ST, Buitrago, S, Coffman, TM, Duffield, JS, Gross, KW, and Shankland, SJ. "Cells of renin lineage are progenitors of podocytes and parietal epithelial cells in experimental glomerular disease." American Journal of Pathology 183, no. 2 (2013): 542-557.

PMID
23769837
Full Text

Sparks, MA, Makhanova, NA, Griffiths, RC, Snouwaert, JN, Koller, BH, and Coffman, TM. "Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death." Hypertension 61, no. 1 (January 2013): 166-173.

PMID
23150508
Full Text

Herrera, M, Sparks, MA, Alfonso-Pecchio, AR, Harrison-Bernard, LM, and Coffman, TM. "Lack of specificity of commercial antibodies leads to misidentification of angiotensin type 1 receptor protein." Hypertension 61, no. 1 (January 2013): 253-258.

PMID
23150519
Full Text

Desai, T, Sparks, MA, Nair, V, Sethi, SK, Topf, J, Calderon, K, Bury, E, and Jhaveri, KD. "The state of the blog: The first year of eAJKD." American Journal of Kidney Diseases 61, no. 1 (2013): 1-2.

PMID
23245735
Full Text

Jhaveri, KD, Sparks, MA, Shah, HH, Khan, S, Chawla, A, Desai, T, Iglesia, E, Ferris, M, Parker, MG, and Kohan, DE. "Why not nephrology? A survey of us internal medicine subspecialty fellows." American Journal of Kidney Diseases 61, no. 4 (2013): 540-546.

PMID
23332603
Full Text

Shah, HH, Jhaveri, KD, Sparks, MA, and Mattana, J. "Career choice selection and satisfaction among US adult nephrology fellows." Clin J Am Soc Nephrol 7, no. 9 (September 2012): 1513-1520.

PMID
22745273
Full Text

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