Matthew A. Sparks, MD

Associate Professor of Medicine
Campus mail 2 Genome Court, Msrb2 Room 1013, Box 103015, Durham, NC 27710
Phone (919) 684-9737
Email address matthew.sparks@duke.edu

I serve as the Program Director for the Nephrology Fellowship Program. My goal is to work with each fellow to ensure they develop a successful career in whatever direction they choose. I am the lead for the newly established Society for Early Education Scholars (SEEDS) in the Department of Medicine. The SEEDS Program is a year-long mentored education program designed for fellows planning careers as clinician educators or education scholars.

Nephrology Fellowship Program

My laboratory is interested in understanding how both the renin-angiotensin and prostanoid systems regulate blood pressure by altering blood flow to the kidney. We use a combination of physiologic and molecular techniques in genetically modified mice to probe questions about how changes in the micro circulation in the kidney alter sodium excretion. The overarching goal of this research is to identify novel mechanisms to target drug therapy for patients with hypertension. My research has been funded by the Department of Veterans Affairs Office of Research and Development and the American Heart Association. We also explore the link between pulmonary hypertension and CKD.

Sparks Laboratory Website

I'm also interested finding ways to promote medical education. My focus is on leveraging social media to enhance learning in nephrology. I serve as program director for the Nephrology Social Media Collective (NSMC) internship and member of the board of directors of nephrology journal club (NephJC), a non-profit organization dedicated to enhancing free online medical education in nephrology. I am also co-founder and advisory board member of the first nephrology blog associated with a journal- AJKD blog, the official blog of the American Journal of Kidney Diseases. Co-creator of the popular educational project NephMadness. Past deputy editor of Renal Fellow Network where I continue to remain as faculty lead. I am currently a member of the Nephrology Board of the American Board of Internal Medicine, the Scientific and Clinical Education Lifelong learning Committee Chair, Kidney in Cardiovascular Disease Council of the American Heart Association and am a fellow of the American Society of Nephrology, the American Heart Association, and the National Kidney Foundation. 

I serve as Education Director for KIDNEYcon- a yearly hands-on conference dedicated to advances in nephrology held in Little Rock, AR each April.

Listen to my podcast "The Nephron Segment"

@Nephro_Sparks on Twitter

Education and Training

  • Fellow in Nephrology, Medicine, Duke University School of Medicine, 2007 - 2011
  • Chief Resident, Medicine, University of Arkansas for Medical Sciences, College of Medicine, 2006 - 2007
  • Resident, Medicine, University of Arkansas for Medical Sciences, College of Medicine, 2003 - 2006
  • M.D., University of Arkansas for Medical Sciences, College of Medicine, 2003

Publications

Wysocki, Jan, David I. Ortiz-Melo, Natalie K. Mattocks, Katherine Xu, Jessica Prescott, Karla Evora, Minghao Ye, et al. “ACE2 deficiency increases NADPH-mediated oxidative stress in the kidney.” Physiol Rep 2, no. 3 (2014): e00264. https://doi.org/10.1002/phy2.264.

PMID
24760518
Full Text

Xie, Luke, Matthew A. Sparks, Wei Li, Yi Qi, Chunlei Liu, Thomas M. Coffman, and G Allan Johnson. “Quantitative susceptibility mapping of kidney inflammation and fibrosis in type 1 angiotensin receptor-deficient mice.” Nmr Biomed 26, no. 12 (December 2013): 1853–63. https://doi.org/10.1002/nbm.3039.

PMID
24154952
Full Text

Malone, Andrew F., Matthew A. Sparks, David N. Howell, John Paul Middleton, Stephen R. Smith, and Ruediger W. Lehrich. “IgG4-related tubulointerstitial nephritis associated with chronic lymphocytic leukemia.” J Nephrol 26, no. 6 (November 2013): 1195–98. https://doi.org/10.5301/jn.5000298.

PMID
24284523
Full Text

Pippin, Jeffrey W., Matthew A. Sparks, Sean T. Glenn, Sandra Buitrago, Thomas M. Coffman, Jeremy S. Duffield, Kenneth W. Gross, and Stuart J. Shankland. “Cells of renin lineage are progenitors of podocytes and parietal epithelial cells in experimental glomerular disease.” Am J Pathol 183, no. 2 (August 2013): 542–57. https://doi.org/10.1016/j.ajpath.2013.04.024.

PMID
23769837
Full Text

Jhaveri, Kenar D., Matthew A. Sparks, and Hitesh H. Shah. “Novel educational approaches to enhance learning and interest in nephrology.” Adv Chronic Kidney Dis 20, no. 4 (July 2013): 336–46. https://doi.org/10.1053/j.ackd.2013.03.006.

PMID
23809286
Full Text

Jhaveri, Kenar D., Matthew A. Sparks, Hitesh H. Shah, Seyyar Khan, Arun Chawla, Tejas Desai, Edward Iglesia, Maria Ferris, Mark G. Parker, and Donald E. Kohan. “Why not nephrology? A survey of US internal medicine subspecialty fellows.” Am J Kidney Dis 61, no. 4 (April 2013): 540–46. https://doi.org/10.1053/j.ajkd.2012.10.025.

PMID
23332603
Full Text

Sparks, Matthew A., Natalia A. Makhanova, Robert C. Griffiths, John N. Snouwaert, Beverly H. Koller, and Thomas M. Coffman. “Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death.” Hypertension 61, no. 1 (January 2013): 166–73. https://doi.org/10.1161/HYPERTENSIONAHA.112.193250.

PMID
23150508
Full Text

Herrera, Marcela, Matthew A. Sparks, Adolfo R. Alfonso-Pecchio, Lisa M. Harrison-Bernard, and Thomas M. Coffman. “Lack of specificity of commercial antibodies leads to misidentification of angiotensin type 1 receptor protein.” Hypertension 61, no. 1 (January 2013): 253–58. https://doi.org/10.1161/HYPERTENSIONAHA.112.203679.

PMID
23150519
Full Text

Desai, Tejas, Matthew A. Sparks, Vinay Nair, Sidharth Kumar Sethi, Joel Topf, Kellie Calderon, Elizabeth Bury, and Kenar D. Jhaveri. “The state of the blog: the first year of eAJKD.” Am J Kidney Dis 61, no. 1 (January 2013): 1–2. https://doi.org/10.1053/j.ajkd.2012.10.013.

PMID
23245735
Full Text

Shah, Hitesh H., Kenar D. Jhaveri, Matthew A. Sparks, and Joseph Mattana. “Career choice selection and satisfaction among US adult nephrology fellows.” Clin J Am Soc Nephrol 7, no. 9 (September 2012): 1513–20. https://doi.org/10.2215/CJN.01620212.

PMID
22745273
Full Text

Pages