Matthew A. Sparks, MD

Associate Professor of Medicine
Campus mail 2 Genome Court, Msrb2 Room 1013, Box 103015, Durham, NC 27710
Phone (919) 684-9737
Email address matthew.sparks@duke.edu

I serve as the Program Director for the Nephrology Fellowship Program. My goal is to work with each fellow to ensure they develop a successful career in whatever direction they choose. I am the lead for the newly established Society for Early Education Scholars (SEEDS) in the Department of Medicine. The SEEDS Program is a year-long mentored education program designed for fellows planning careers as clinician educators or education scholars.

Nephrology Fellowship Program

My laboratory is interested in understanding how both the renin-angiotensin and prostanoid systems regulate blood pressure by altering blood flow to the kidney. We use a combination of physiologic and molecular techniques in genetically modified mice to probe questions about how changes in the micro circulation in the kidney alter sodium excretion. The overarching goal of this research is to identify novel mechanisms to target drug therapy for patients with hypertension. My research has been funded by the Department of Veterans Affairs Office of Research and Development and the American Heart Association. We also explore the link between pulmonary hypertension and CKD.

Sparks Laboratory Website

I'm also interested finding ways to promote medical education. My focus is on leveraging social media to enhance learning in nephrology. I serve as program director for the Nephrology Social Media Collective (NSMC) internship and member of the board of directors of nephrology journal club (NephJC), a non-profit organization dedicated to enhancing free online medical education in nephrology. I am also co-founder and advisory board member of the first nephrology blog associated with a journal- AJKD blog, the official blog of the American Journal of Kidney Diseases. Co-creator of the popular educational project NephMadness. Past deputy editor of Renal Fellow Network where I continue to remain as faculty lead. I am currently a member of the Nephrology Board of the American Board of Internal Medicine, the Scientific and Clinical Education Lifelong learning Committee Chair, Kidney in Cardiovascular Disease Council of the American Heart Association and am a fellow of the American Society of Nephrology, the American Heart Association, and the National Kidney Foundation. 

I serve as Education Director for KIDNEYcon- a yearly hands-on conference dedicated to advances in nephrology held in Little Rock, AR each April.

Listen to my podcast "The Nephron Segment"

@Nephro_Sparks on Twitter

Education and Training

  • Fellow in Nephrology, Medicine, Duke University School of Medicine, 2007 - 2011
  • Chief Resident, Medicine, University of Arkansas for Medical Sciences, College of Medicine, 2006 - 2007
  • Resident, Medicine, University of Arkansas for Medical Sciences, College of Medicine, 2003 - 2006
  • M.D., University of Arkansas for Medical Sciences, College of Medicine, 2003

Publications

Zhang, Jian-dong, Mehul B. Patel, Young-Soo Song, Robert Griffiths, James Burchette, Phillip Ruiz, Matthew A. Sparks, et al. “A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension.” Circ Res 110, no. 12 (June 8, 2012): 1604–17. https://doi.org/10.1161/CIRCRESAHA.111.261768.

PMID
22534490
Full Text

Stegbauer, Johannes, Susan B. Gurley, Matthew A. Sparks, Magdalena Woznowski, Donald E. Kohan, Ming Yan, Ruediger W. Lehrich, and Thomas M. Coffman. “AT1 receptors in the collecting duct directly modulate the concentration of urine.” J Am Soc Nephrol 22, no. 12 (December 2011): 2237–46. https://doi.org/10.1681/ASN.2010101095.

PMID
22052052
Full Text

Sparks, Matthew A., Conall M. O’Seaghdha, Sidharth Kumar Sethi, and Kenar D. Jhaveri. “Embracing the Internet as a means of enhancing medical education in nephrology.” Am J Kidney Dis 58, no. 4 (October 2011): 512–18. https://doi.org/10.1053/j.ajkd.2011.06.009.

PMID
21840099
Full Text

Gurley, Susan B., Anne D. M. Riquier-Brison, Jurgen Schnermann, Matthew A. Sparks, Andrew M. Allen, Volker H. Haase, John N. Snouwaert, et al. “AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure.” Cell Metab 13, no. 4 (April 6, 2011): 469–75. https://doi.org/10.1016/j.cmet.2011.03.001.

PMID
21459331
Full Text

Eckel, Jason, Peter J. Lavin, Elizabeth A. Finch, Nirvan Mukerji, Jarrett Burch, Rasheed Gbadegesin, Guanghong Wu, et al. “TRPC6 enhances angiotensin II-induced albuminuria.” J Am Soc Nephrol 22, no. 3 (March 2011): 526–35. https://doi.org/10.1681/ASN.2010050522.

PMID
21258036
Full Text

Sparks, Matthew A., Kelly K. Parsons, Johannes Stegbauer, Susan B. Gurley, Anuradha Vivekanandan-Giri, Christopher N. Fortner, Jay Snouwaert, et al. “Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension.” Hypertension 57, no. 3 (March 2011): 577–85. https://doi.org/10.1161/HYPERTENSIONAHA.110.165274.

PMID
21242463
Full Text

Sparks, Matthew A., and Thomas M. Coffman. “The EP4 receptor for prostaglandin E2 in glomerular disease: a good receptor turned bad?” J Am Soc Nephrol 21, no. 10 (October 2010): 1597–99. https://doi.org/10.1681/ASN.2010080870.

PMID
20829404
Full Text

Crowley, S. D., Y. S. Song, G. Sprung, R. Griffiths, M. Sparks, M. Yan, J. L. Burchette, et al. “Response to angiotensin II type 1a-deficient bone marrow-derived dendritic cells produce higher levels of monocyte chemoattractant protein 1.” Hypertension 56, no. 1 (July 1, 2010). https://doi.org/10.1161/HYPERTENSIONAHA.110.153544.

Full Text

Crowley, Steven D., Young-Soo Song, Gregory Sprung, Robert Griffiths, Matthew Sparks, Ming Yan, James L. Burchette, et al. “A role for angiotensin II type 1 receptors on bone marrow-derived cells in the pathogenesis of angiotensin II-dependent hypertension.” Hypertension 55, no. 1 (January 2010): 99–108. https://doi.org/10.1161/HYPERTENSIONAHA.109.144964.

PMID
19996062
Full Text

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