Matthew Todd Roe, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8959
Email address roe00001@mc.duke.edu

My clinical activities focus upon general, preventive, and acute care cardiology.  I round regularly on the inpatient general cardiology and coronary care unit (CCU) services and i have a particular interest in the treatment and management of patients with acute myocardial infarction and cardiogenic shock.  In my outpatient clinic, I care for patients with a variety of cardiovascular conditions include chronic coronary artery disease, hypertension, hyperlipidemia, atrial fibrillation, congestive heart failure, aortic aneurysms, and peripheral arterial disease.  In this setting, I have a particular interest in cardiovascular risk factor modification and long-term treatment strategies to mitigate the risk of future cardiovascular events.

My research activities at the Duke Clinical Research Institute focus upon the coordination and leadership of randomized clinical trials evaluating new therapies for a variety of cardiovascular conditions (acute myocardial infarction, hyperlipidemia, coronary stent placement, peripheral arterial disease, and coronary artery disease) as well as observational registries that evaluate the same disease conditions.

Education and Training

  • Cardiology Fellow, Cardiology, Case Western Reserve University, 1996 - 1999
  • Medical Resident, Medicine, Duke University, 1993 - 1996
  • M.D., Duke University, 1993

Publications

Fordyce, Christopher B., Matthew T. Roe, Christine Pierre, Terri Hinkley, Gerrit Hamre, Pamela Tenaerts, Jonathan McCall, and James D. Topping. “Trends in clinical trial investigator workforce and turnover: An analysis of the U.S. FDA 1572 BMIS database..” Contemp Clin Trials Commun 15 (September 2019). https://doi.org/10.1016/j.conctc.2019.100380.

PMID
31193608
Full Text

Steg, Philippe Gabriel, Michael Szarek, Deepak L. Bhatt, Vera A. Bittner, Marie-France Brégeault, Anthony J. Dalby, Rafael Diaz, et al. “Effect of Alirocumab on Mortality After Acute Coronary Syndromes..” Circulation 140, no. 2 (July 9, 2019): 103–12. https://doi.org/10.1161/CIRCULATIONAHA.118.038840.

PMID
31117810
Full Text

Povsic, Thomas J., E Magnus Ohman, Matthew T. Roe, Jennifer White, Frank W. Rockhold, Gilles Montalescot, Jan H. Cornel, et al. “P2Y12 Inhibitor Switching in Response to Routine Notification of CYP2C19 Clopidogrel Metabolizer Status Following Acute Coronary Syndromes..” In Jama Cardiol, 2019. https://doi.org/10.1001/jamacardio.2019.1510.

PMID
31141104
Full Text

Fanaroff, Alexander C., Amit N. Vora, Anita Y. Chen, Robin Mathews, Jacob A. Udell, Matthew T. Roe, Laine E. Thomas, and Tracy Y. Wang. “Hospital participation in clinical trials for patients with acute myocardial infarction: Results from the National Cardiovascular Data Registry..” Am Heart J 214 (May 25, 2019): 184–93. https://doi.org/10.1016/j.ahj.2019.05.011.

PMID
31234037
Full Text

White, Harvey D., Ph Gabriel Steg, Michael Szarek, Deepak L. Bhatt, Vera A. Bittner, Rafael Diaz, Jay M. Edelberg, et al. “Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial..” Eur Heart J, May 23, 2019. https://doi.org/10.1093/eurheartj/ehz299.

PMID
31121022
Full Text

Sharma, Abhinav, Jie-Lena Sun, Yuliya Lokhnygina, Matthew T. Roe, Tariq Ahmad, Nihar R. Desai, and Michael A. Blazing. “Patient Phenotypes, Cardiovascular Risk, and Ezetimibe Treatment in Patients After Acute Coronary Syndromes (from IMPROVE-IT)..” Am J Cardiol 123, no. 8 (April 15, 2019): 1193–1201. https://doi.org/10.1016/j.amjcard.2019.01.034.

PMID
30739657
Full Text

Kaul, Padma, Karen P. Alexander, E Magnus Ohman, Anamaria Savu, Matthew T. Roe, Shaun G. Goodman, Keith A. Fox, et al. “Sex And Prognostic Significance of Self-Reported Frailty in Non-ST-Segment Elevation Acute Coronary Syndromes: Insights From the TRILOGY ACS Trial..” Can J Cardiol 35, no. 4 (April 2019): 430–37. https://doi.org/10.1016/j.cjca.2018.12.035.

PMID
30935633
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Jukema, J Wouter, Michael Szarek, Laurien E. Zijlstra, H Asita de Silva, Deepak L. Bhatt, Vera A. Bittner, Rafael Diaz, et al. “Patients with Recent Acute Coronary Syndrome and Polyvascular Disease Derive Large Absolute Benefit from Alirocumab: ODYSSEY OUTCOMES Trial..” J Am Coll Cardiol, March 12, 2019. https://doi.org/10.1016/j.jacc.2019.03.013.

PMID
30898609
Full Text

Kontos, Michael C., Christopher B. Fordyce, Anita Y. Chen, Karen Chiswell, Jonathan R. Enriquez, James de Lemos, and Matthew T. Roe. “Association of acute myocardial infarction cardiac arrest patient volume and in-hospital mortality in the United States: Insights from the National Cardiovascular Data Registry Acute Coronary Treatment And Intervention Outcomes Network Registry..” Clin Cardiol 42, no. 3 (March 2019): 352–57. https://doi.org/10.1002/clc.23146.

PMID
30597584
Full Text

Pages