Matthew Todd Roe, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8959
Email address roe00001@mc.duke.edu

My clinical activities focus upon general, preventive, and acute care cardiology.  I round regularly on the inpatient general cardiology and coronary care unit (CCU) services and i have a particular interest in the treatment and management of patients with acute myocardial infarction and cardiogenic shock.  In my outpatient clinic, I care for patients with a variety of cardiovascular conditions include chronic coronary artery disease, hypertension, hyperlipidemia, atrial fibrillation, congestive heart failure, aortic aneurysms, and peripheral arterial disease.  In this setting, I have a particular interest in cardiovascular risk factor modification and long-term treatment strategies to mitigate the risk of future cardiovascular events.

My research activities at the Duke Clinical Research Institute focus upon the coordination and leadership of randomized clinical trials evaluating new therapies for a variety of cardiovascular conditions (acute myocardial infarction, hyperlipidemia, coronary stent placement, peripheral arterial disease, and coronary artery disease) as well as observational registries that evaluate the same disease conditions.

Education and Training

  • Cardiology Fellow, Cardiology, Case Western Reserve University, 1996 - 1999
  • Medical Resident, Medicine, Duke University, 1993 - 1996
  • M.D., Duke University, 1993

Publications

Marquis-Gravel, Guillaume, Matthew T. Roe, Robert A. Harrington, Daniel Muñoz, Adrian F. Hernandez, and W Schuyler Jones. “Revisiting the Role of Aspirin for the Primary Prevention of Cardiovascular Disease..” Circulation 140, no. 13 (September 24, 2019): 1115–24. https://doi.org/10.1161/CIRCULATIONAHA.119.040205.

PMID
31545683
Full Text

Kwee, Lydia Coulter, Megan L. Neely, Elizabeth Grass, Simon G. Gregory, Matthew T. Roe, E Magnus Ohman, Keith A. A. Fox, et al. “Associations of Osteopontin and NT-proBNP with Circulating miRNA Levels in Acute Coronary Syndrome..” Physiol Genomics, September 18, 2019. https://doi.org/10.1152/physiolgenomics.00033.2019.

PMID
31530226
Full Text

Roe, Matthew T., and Guillaume Marquis-Gravel. “Overcoming the Risk-Treatment Paradox for Non-ST-Segment Elevation Acute Coronary Syndromes..” J Am Coll Cardiol 74, no. 11 (September 17, 2019): 1462–64. https://doi.org/10.1016/j.jacc.2019.07.031.

PMID
31514948
Full Text

Jukema, J Wouter, Michael Szarek, Laurien E. Zijlstra, H Asita de Silva, Deepak L. Bhatt, Vera A. Bittner, Rafael Diaz, et al. “Alirocumab in Patients With Polyvascular Disease and Recent Acute Coronary Syndrome: ODYSSEY OUTCOMES Trial..” J Am Coll Cardiol 74, no. 9 (September 3, 2019): 1167–76. https://doi.org/10.1016/j.jacc.2019.03.013.

PMID
30898609
Full Text

Bagai, Akshay, Anita Y. Chen, Jacob A. Udell, John A. Dodson, David D. McManus, Mathew S. Maurer, Jonathan R. Enriquez, et al. “Association of Cognitive Impairment With Treatment and Outcomes in Older Myocardial Infarction Patients: A Report From the NCDR Chest Pain-MI Registry..” J Am Heart Assoc 8, no. 17 (September 3, 2019). https://doi.org/10.1161/JAHA.119.012929.

PMID
31462138
Full Text

Goodman, Shaun G., Philip E. Aylward, Michael Szarek, Vakhtang Chumburidze, Deepak L. Bhatt, Vera A. Bittner, Rafael Diaz, et al. “Effects of Alirocumab on Cardiovascular Events After Coronary Bypass Surgery..” J Am Coll Cardiol 74, no. 9 (September 3, 2019): 1177–86. https://doi.org/10.1016/j.jacc.2019.07.015.

PMID
31466614
Full Text

Roe, Matthew T., Qian H. Li, Deepak L. Bhatt, Vera A. Bittner, Rafael Diaz, Shaun G. Goodman, Robert A. Harrington, et al. “Risk Categorization Using New American College of Cardiology/American Heart Association Guidelines for Cholesterol Management and Its Relation to Alirocumab Treatment Following Acute Coronary Syndromes..” Circulation, September 2, 2019. https://doi.org/10.1161/CIRCULATIONAHA.119.042551.

PMID
31475572
Full Text

White, Harvey D., Ph Gabriel Steg, Michael Szarek, Deepak L. Bhatt, Vera A. Bittner, Rafael Diaz, Jay M. Edelberg, et al. “Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial..” Eur Heart J 40, no. 33 (September 1, 2019): 2801–9. https://doi.org/10.1093/eurheartj/ehz299.

PMID
31121022
Full Text

Fordyce, Christopher B., Matthew T. Roe, Christine Pierre, Terri Hinkley, Gerrit Hamre, Pamela Tenaerts, Jonathan McCall, and James D. Topping. “Trends in clinical trial investigator workforce and turnover: An analysis of the U.S. FDA 1572 BMIS database..” Contemp Clin Trials Commun 15 (September 2019). https://doi.org/10.1016/j.conctc.2019.100380.

PMID
31193608
Full Text

Duell, P Barton, Samuel S. Gidding, Rolf L. Andersen, Thomas Knickelbine, Lars Anderson, Eugenia Gianos, Peter Shrader, et al. “Longitudinal low density lipoprotein cholesterol goal achievement and cardiovascular outcomes among adult patients with familial hypercholesterolemia: The CASCADE FH registry..” Atherosclerosis 289 (August 19, 2019): 85–93. https://doi.org/10.1016/j.atherosclerosis.2019.08.007.

PMID
31487564
Full Text

Pages