Infectious Diseases

Matthias Gromeier, MD

Professor of Neurosurgery
Professor in Molecular Genetics and Microbiology
Professor in Medicine
Member of the Duke Cancer Institute
Campus mail Box 3020 Med Ctr, Durham, NC 27710
Phone (919) 668-6205
Email address grome001@mc.duke.edu

I am a classically trained virologist with a focus on molecular mechanisms of RNA virus pathogenesis. My career is dedicated to unraveling RNA virus:host relations and devising methods of exploiting them for cancer immunotherapy and vaccine design. My background is in translation regulation and mRNA metabolism, viral RNA sensing and innate immunity, and cancer immunology and immunotherapy. Basic mechanistic research in my laboratory is supporting an ambitious clinical translational research program with active multi-center clinical trials in several cancer indications. 

Education and Training

  • Postdoctoral Associate, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1996 - 1999
  • Postdoctoral fellow, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1993 - 1996
  • M.D., University of Hamburg (Germany), 1992

Grants

Publications

Merrill, M., D. Solecki, and M. Gromeier. “Poliovirus recombinants against malignant glioma.” In Viral Therapy of Human Cancers, 739–80, 2004.

Scholars@Duke

Cello, J., N. De Jesus, K. Chumakov, J. Yin, A. V. Paul, M. Gromeier, and E. Wimmer. “A new polio vaccine?” In Vaccines: Preventing Disease and Protecting Health, edited by C. A. DeQuadros, 183–88. PAN AMERICAN HEALTH ORGANIZATION, 2004.

Scholars@Duke

Scheuner, Donalyn, Matthias Gromeier, Monique V. Davies, Andrew J. Dorner, Benbo Song, Rupali V. Patel, Eckard J. Wimmer, Roger E. McLendon, and Randal J. Kaufman. “The double-stranded RNA-activated protein kinase mediates viral-induced encephalitis.” Virology 317, no. 2 (December 20, 2003): 263–74. https://doi.org/10.1016/j.virol.2003.08.010.

PMID
14698665
Full Text

Dobrikova, Elena, Paola Florez, Shelton Bradrick, and Matthias Gromeier. “Activity of a type 1 picornavirus internal ribosomal entry site is determined by sequences within the 3' nontranslated region.” Proc Natl Acad Sci U S A 100, no. 25 (December 9, 2003): 15125–30. https://doi.org/10.1073/pnas.2436464100.

PMID
14645707
Full Text

Dobrikova, Elena Y., Paola Florez, and Matthias Gromeier. “Structural determinants of insert retention of poliovirus expression vectors with recombinant IRES elements.” Virology 311, no. 2 (July 5, 2003): 241–53. https://doi.org/10.1016/s0042-6822(03)00191-0.

PMID
12842615
Full Text

Fecci, Peter E., Matthias Gromeier, and John H. Sampson. “Viruses in the treatment of brain tumors.” Neuroimaging Clin N Am 12, no. 4 (November 2002): 553–70. https://doi.org/10.1016/s1052-5149(02)00028-x.

PMID
12687911
Full Text

Gromeier, M. “Viruses for treating cancer.” Asm News 68, no. 9 (September 1, 2002): 438-+.

Scholars@Duke

Dufresne, Andrew T., Elena Y. Dobrikova, Stacie Schmidt, and Matthias Gromeier. “Genetically stable picornavirus expression vectors with recombinant internal ribosomal entry sites.” J Virol 76, no. 17 (September 2002): 8966–72. https://doi.org/10.1128/jvi.76.17.8966-8972.2002.

PMID
12163617
Full Text

Solecki, David J., Matthias Gromeier, Steffen Mueller, Günter Bernhardt, and Eckard Wimmer. “Expression of the human poliovirus receptor/CD155 gene is activated by sonic hedgehog.” J Biol Chem 277, no. 28 (July 12, 2002): 25697–702. https://doi.org/10.1074/jbc.M201378200.

PMID
11983699
Full Text

Pages