Matthias Gromeier, MD

Professor of Neurosurgery
Professor in Molecular Genetics and Microbiology
Professor in Medicine
Member of the Duke Cancer Institute
Campus mail Box 3020 Med Ctr, Durham, NC 27710
Phone (919) 668-6205
Email address grome001@mc.duke.edu

I am a classically trained virologist with a focus on molecular mechanisms of RNA virus pathogenesis. My career is dedicated to unraveling RNA virus:host relations and devising methods of exploiting them for cancer immunotherapy and vaccine design. My background is in translation regulation and mRNA metabolism, viral RNA sensing and innate immunity, and cancer immunology and immunotherapy. Basic mechanistic research in my laboratory is supporting an ambitious clinical translational research program with active multi-center clinical trials in several cancer indications. 

Education and Training

  • Postdoctoral Associate, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1996 - 1999
  • Postdoctoral fellow, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1993 - 1996
  • M.D., University of Hamburg (Germany), 1992

Publications

Merrill, M., E. Dobrikova, and M. Gromeier. “Oncolytic poliovirus recombinants for the treatment of malignant glioma.” In Gene Therapy, 8:S4–S4. NATURE PUBLISHING GROUP, 2001.

Scholars@Duke

Gromeier, M., and E. Wimmer. “Viruses for the treatment of malignant glioma.” Curr Opin Mol Ther 3, no. 5 (October 2001): 503–8.

PMID
11699896
Scholars@Duke

Chumakov, K., E. Dragunsky, A. Ivshina, J. Enterline, V. Wells, T. Nomura, M. Gromeier, and E. Wimmer. “Inactivated vaccines based on alternatives to wild-type seed virus.” Dev Biol (Basel) 105 (2001): 171–77.

PMID
11763325
Scholars@Duke

Gromeier, M., D. Solecki, D. D. Patel, and E. Wimmer. “Expression of the human poliovirus receptor/CD155 gene during development of the central nervous system: implications for the pathogenesis of poliomyelitis.” Virology 273, no. 2 (August 1, 2000): 248–57. https://doi.org/10.1006/viro.2000.0418.

PMID
10915595
Full Text

Gromeier, M., S. Lachmann, M. R. Rosenfeld, P. H. Gutin, and E. Wimmer. “Intergeneric poliovirus recombinants for the treatment of malignant glioma.” Proc Natl Acad Sci U S A 97, no. 12 (June 6, 2000): 6803–8. https://doi.org/10.1073/pnas.97.12.6803.

PMID
10841575
Full Text

GROMEIER, M. “Intergeneric poliovirus recombinants for the treatment of malignant glioma.” Proc Natl Acad Sci Usa 97 (2000): 6803–8.

Scholars@Duke

McCloskey, B. P. “The relation of prophylactic inoculations to the onset of poliomyelitis. 1950.” Rev Med Virol 9, no. 4 (October 1999): 219–26. https://doi.org/10.1002/(sici)1099-1654(199910/12)9:4<219::aid-rmv249>3.0.co;2-t.

PMID
10578117
Full Text

Gromeier, M., B. Bossert, M. Arita, A. Nomoto, and E. Wimmer. “Dual stem loops within the poliovirus internal ribosomal entry site control neurovirulence.” J Virol 73, no. 2 (February 1999): 958–64. https://doi.org/10.1128/JVI.73.2.958-964.1999.

PMID
9882296
Full Text

Das, S., M. Ott, A. Yamane, W. M. Tsai, M. Gromeier, F. Lahser, S. Gupta, and A. Dasgupta. “A small yeast RNA blocks hepatitis C virus internal ribosome entry site (HCV IRES)-mediated translation and inhibits replication of a chimeric poliovirus under translational control of the HCV IRES element (vol 72, pg 5638, 1998).” Journal of Virology 72, no. 11 (November 1, 1998): 9419–9419.

Scholars@Duke

Pages