Matthias Gromeier, MD

Professor of Neurosurgery
Professor in Molecular Genetics and Microbiology
Professor in Medicine
Member of the Duke Cancer Institute
Campus mail Box 3020 Med Ctr, Durham, NC 27710
Phone (919) 668-6205
Email address

I am a classically trained virologist with a focus on molecular mechanisms of RNA virus pathogenesis. My career is dedicated to unraveling RNA virus:host relations and devising methods of exploiting them for cancer immunotherapy and vaccine design. My background is in translation regulation and mRNA metabolism, viral RNA sensing and innate immunity, and cancer immunology and immunotherapy. Basic mechanistic research in my laboratory is supporting an ambitious clinical translational research program with active multi-center clinical trials in several cancer indications. 

Education and Training

  • Postdoctoral Associate, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1996 - 1999
  • Postdoctoral fellow, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1993 - 1996
  • M.D., University of Hamburg (Germany), 1992


Gromeier, M., H. H. Lu, G. Bernhardt, J. J. Harber, J. A. Bibb, and E. Wimmer. “The human poliovirus receptor. Receptor-virus interaction and parameters of disease specificity.” Ann N Y Acad Sci 753 (May 25, 1995): 19–36.

Full Text

Gromeier, M., H. H. Lu, and E. Wimmer. “Mouse neuropathogenic poliovirus strains cause damage in the central nervous system distinct from poliomyelitis.” Microb Pathog 18, no. 4 (April 1995): 253–67.

Full Text

WIMMER, E., J. J. HARBER, J. A. BIBB, M. GROMEIER, H. H. LU, and G. BERNHARDT. “POLIOVIRUS RECEPTORS.” In Cellular Receptors for Animal Viruses, edited by E. Wimmer, 101–27. COLD SPRING HARBOR LABORATORY PRESS, 1994.


LU, H. H., L. ALEXANDER, M. GROMEIER, and E. WIMMER. “DICISTRONIC POLIOVIRUSES EXPRESSING THE ANTIGENIC DETERMINANTS FROM GP120 OF HIV-1.” In Vaccines 94  Modern Approaches to New Vaccines Including Prevention of Aids, edited by E. Norrby, F. Brown, R. M. Chanock, and H. S. Ginsberg, 161–67. COLD SPRING HARBOR LABORATORY PRESS, 1994.


Alexander, L., H. H. Lu, M. Gromeier, and E. Wimmer. “Dicistronic polioviruses as expression vectors for foreign genes.” Aids Res Hum Retroviruses 10 Suppl 2 (1994): S57–60.


Desjardins, Annick, John Sampson, Katherine Peters, Gordana Vlahoci, Dina Randazzo, Stevie Threatt, James Herndon, et al. “Oncolytic polio/rhinovirus recombinant (PVSRIPO) against recurrent glioblastoma (GBM): Optimal dose determination.,” 33:112s-112s, n.d.