Matthias Gromeier, MD

Professor of Neurosurgery
Professor in Molecular Genetics and Microbiology
Professor in Medicine
Member of the Duke Cancer Institute
Campus mail Box 3020 Med Ctr, Durham, NC 27710
Phone (919) 668-6205
Email address grome001@mc.duke.edu

I am a classically trained virologist with a focus on molecular mechanisms of RNA virus pathogenesis. My career is dedicated to unraveling RNA virus:host relations and devising methods of exploiting them for cancer immunotherapy and vaccine design. My background is in translation regulation and mRNA metabolism, viral RNA sensing and innate immunity, and cancer immunology and immunotherapy. Basic mechanistic research in my laboratory is supporting an ambitious clinical translational research program with active multi-center clinical trials in several cancer indications. 

Education and Training

  • Postdoctoral Associate, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1996 - 1999
  • Postdoctoral fellow, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1993 - 1996
  • M.D., University of Hamburg (Germany), 1992

Publications

Walters, Robert W., Shelton S. Bradrick, and Matthias Gromeier. “Poly(A)-binding protein modulates mRNA susceptibility to cap-dependent miRNA-mediated repression.” Rna 16, no. 1 (January 2010): 239–50. https://doi.org/10.1261/rna.1795410.

PMID
19934229
Full Text

Dobrikova, Elena, Mayya Shveygert, Robert Walters, and Matthias Gromeier. “Herpes simplex virus proteins ICP27 and UL47 associate with polyadenylate-binding protein and control its subcellular distribution.” J Virol 84, no. 1 (January 2010): 270–79. https://doi.org/10.1128/JVI.01740-09.

PMID
19864386
Full Text

Gromeier, Matthias, Valentina Neplioueva, Neel Makherjee, Melinda Merrill, and John H. Sampson. “THE RNA-BINDING PROTEIN 76 CONTROLS GENE EXPRESSION IN GBM.” Neuro Oncology 11, no. 2 (April 1, 2009): 221–221.

Scholars@Duke

Yang, Xiaoyi, Eying Chen, Hengguang Jiang, Karen Muszynski, Raymond D. Harris, Steven L. Giardina, Matthias Gromeier, Gautam Mitra, and Gopalan Soman. “Evaluation of IRES-mediated, cell-type-specific cytotoxicity of poliovirus using a colorimetric cell proliferation assay.” J Virol Methods 155, no. 1 (January 2009): 44–54. https://doi.org/10.1016/j.jviromet.2008.09.020.

PMID
18951922
Full Text

Dobrikova, Elena Y., Trevor Broadt, Judith Poiley-Nelson, Xiaoyi Yang, Gopalan Soman, Steve Giardina, Ray Harris, and Matthias Gromeier. “Recombinant oncolytic poliovirus eliminates glioma in vivo without genetic adaptation to a pathogenic phenotype.” Mol Ther 16, no. 11 (November 2008): 1865–72. https://doi.org/10.1038/mt.2008.184.

PMID
18766173
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Kaiser, Constanze, Elena Y. Dobrikova, Shelton S. Bradrick, Mayya Shveygert, James T. Herbert, and Matthias Gromeier. “Activation of cap-independent translation by variant eukaryotic initiation factor 4G in vivo.” Rna 14, no. 10 (October 2008): 2170–82. https://doi.org/10.1261/rna.1171808.

PMID
18755839
Full Text

Everson, Richard G., Michael W. Graner, Matthias Gromeier, James J. Vredenburgh, Annick Desjardins, David A. Reardon, Henry S. Friedman, Allan H. Friedman, Darell D. Bigner, and John H. Sampson. “Immunotherapy against angiogenesis-associated targets: evidence and implications for the treatment of malignant glioma.” Expert Rev Anticancer Ther 8, no. 5 (May 2008): 717–32. https://doi.org/10.1586/14737140.8.5.717.

PMID
18471045
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Selznick, Lee A., Mohammed F. Shamji, Peter Fecci, Matthias Gromeier, Allan H. Friedman, and John Sampson. “Molecular strategies for the treatment of malignant glioma--genes, viruses, and vaccines.” Neurosurg Rev 31, no. 2 (April 2008): 141–55. https://doi.org/10.1007/s10143-008-0121-0.

PMID
18259789
Full Text

Cello, Jeronimo, Hidemi Toyoda, Nidia Dejesus, Elena Y. Dobrikova, Matthias Gromeier, and Eckard Wimmer. “Growth phenotypes and biosafety profiles in poliovirus-receptor transgenic mice of recombinant oncolytic polio/human rhinoviruses.” J Med Virol 80, no. 2 (February 2008): 352–59. https://doi.org/10.1002/jmv.21063.

PMID
18098139
Full Text

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