Matthias Gromeier, MD

Professor of Neurosurgery
Professor in Molecular Genetics and Microbiology
Professor in Medicine
Member of the Duke Cancer Institute
Campus mail Box 3020 Med Ctr, Durham, NC 27710
Phone (919) 668-6205
Email address grome001@mc.duke.edu

I am a classically trained virologist with a focus on molecular mechanisms of RNA virus pathogenesis. My career is dedicated to unraveling RNA virus:host relations and devising methods of exploiting them for cancer immunotherapy and vaccine design. My background is in translation regulation and mRNA metabolism, viral RNA sensing and innate immunity, and cancer immunology and immunotherapy. Basic mechanistic research in my laboratory is supporting an ambitious clinical translational research program with active multi-center clinical trials in several cancer indications. 

Education and Training

  • Postdoctoral Associate, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1996 - 1999
  • Postdoctoral fellow, Molecular Genetics & Microbiology, State University of New York, Stony Brook, 1993 - 1996
  • M.D., University of Hamburg (Germany), 1992

Publications

Kaiser, Constanze, Elena Y. Dobrikova, Shelton S. Bradrick, Mayya Shveygert, James T. Herbert, and Matthias Gromeier. “Activation of cap-independent translation by variant eukaryotic initiation factor 4G in vivo.” Rna 14, no. 10 (October 2008): 2170–82. https://doi.org/10.1261/rna.1171808.

PMID
18755839
Full Text

Everson, Richard G., Michael W. Graner, Matthias Gromeier, James J. Vredenburgh, Annick Desjardins, David A. Reardon, Henry S. Friedman, Allan H. Friedman, Darell D. Bigner, and John H. Sampson. “Immunotherapy against angiogenesis-associated targets: evidence and implications for the treatment of malignant glioma.” Expert Rev Anticancer Ther 8, no. 5 (May 2008): 717–32. https://doi.org/10.1586/14737140.8.5.717.

PMID
18471045
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Selznick, Lee A., Mohammed F. Shamji, Peter Fecci, Matthias Gromeier, Allan H. Friedman, and John Sampson. “Molecular strategies for the treatment of malignant glioma--genes, viruses, and vaccines.” Neurosurg Rev 31, no. 2 (April 2008): 141–55. https://doi.org/10.1007/s10143-008-0121-0.

PMID
18259789
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Cello, Jeronimo, Hidemi Toyoda, Nidia Dejesus, Elena Y. Dobrikova, Matthias Gromeier, and Eckard Wimmer. “Growth phenotypes and biosafety profiles in poliovirus-receptor transgenic mice of recombinant oncolytic polio/human rhinoviruses.” J Med Virol 80, no. 2 (February 2008): 352–59. https://doi.org/10.1002/jmv.21063.

PMID
18098139
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Bradrick, Shelton S., Elena Y. Dobrikova, Constanze Kaiser, Mayya Shveygert, and Matthias Gromeier. “Poly(A)-binding protein is differentially required for translation mediated by viral internal ribosome entry sites.” Rna 13, no. 9 (September 2007): 1582–93. https://doi.org/10.1261/rna.556107.

PMID
17652408
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Florez de Sessions, Paola, Elena Dobrikova, and Matthias Gromeier. “Genetic adaptation to untranslated region-mediated enterovirus growth deficits by mutations in the nonstructural proteins 3AB and 3CD.” J Virol 81, no. 16 (August 2007): 8396–8405. https://doi.org/10.1128/JVI.00321-07.

PMID
17537861
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Campbell, Stephanie A., Matthew Mulvey, Ian Mohr, and Matthias Gromeier. “Attenuation of herpes simplex virus neurovirulence with picornavirus cis-acting genetic elements.” J Virol 81, no. 2 (January 2007): 791–99. https://doi.org/10.1128/JVI.00714-06.

PMID
17079296
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Merrill, Melinda K., and Matthias Gromeier. “The double-stranded RNA binding protein 76:NF45 heterodimer inhibits translation initiation at the rhinovirus type 2 internal ribosome entry site.” J Virol 80, no. 14 (July 2006): 6936–42. https://doi.org/10.1128/JVI.00243-06.

PMID
16809299
Full Text

Dobrikova, Elena Y., Rachel N. Grisham, Constanze Kaiser, Jennifer Lin, and Matthias Gromeier. “Competitive translation efficiency at the picornavirus type 1 internal ribosome entry site facilitated by viral cis and trans factors.” J Virol 80, no. 7 (April 2006): 3310–21. https://doi.org/10.1128/JVI.80.7.3310-3321.2006.

PMID
16537598
Full Text

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