Mattia Bonsignori, MD

Associate Professor in Medicine
Member of the Duke Human Vaccine Institute
Campus mail 2 Genome Ct, Room 3013, MSRB II, Durham, NC 27710
Phone (919) 684-5858
Email address mattia.bonsignori@duke.edu

HIV vaccine development

Study of B-cell immune responses in HIV positive individuals

Determination of correlates of protective immunity to HIV

Induction of broadly neutralizing antibodies to HIV

Development of multiplex functional assays for the evaluation at a single-cell level of B-cell responses to vaccinations, infections and in vitro stimulation

Epidemiology and characterization of bacterial resistance determinants (past)

Education and Training

  • M.D., University of Insubria (Italy), 2001

Publications

Williams, WB, Zhang, J, Jiang, C, Nicely, NI, Fera, D, Luo, K, Moody, MA, Liao, H-X, Alam, SM, Kepler, TB, Ramesh, A, Wiehe, K, Holland, JA, Bradley, T, Vandergrift, N, Saunders, KO, Parks, R, Foulger, A, Xia, S-M, Bonsignori, M, Montefiori, DC, Louder, M, Eaton, A, Santra, S, Scearce, R, Sutherland, L, Newman, A, Bouton-Verville, H, Bowman, C, Bomze, H, Gao, F, Marshall, DJ, Whitesides, JF, Nie, X, Kelsoe, G, Reed, SG, Fox, CB, Clary, K, Koutsoukos, M, Franco, D, Mascola, JR, and Harrison, SC et al. "Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations." Nature communications 8, no. 1 (November 23, 2017): 1732-.

PMID
29170366
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Yu, J-S, Liao, H-X, Pritchett, J, Bowman, C, Vivian, C, Parks, R, Xia, S-M, Cooper, M, Williams, WB, Bonsignori, M, Reed, SG, Chen, M, Vandergrift, N, Rice, CM, and Haynes, BF. "Development of a recombinant yellow fever vector expressing a HIV clade C founder envelope gp120." Journal of virological methods 249 (November 2017): 85-93.

PMID
28837840
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Hwang, JK, Wang, C, Du, Z, Meyers, RM, Kepler, TB, Neuberg, D, Kwong, PD, Mascola, JR, Joyce, MG, Bonsignori, M, Haynes, BF, Yeap, L-S, and Alt, FW. "Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies." Proceedings of the National Academy of Sciences of the United States of America 114, no. 32 (August 2017): 8614-8619.

PMID
28747530
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Li, H, Williams, W, Bonsignori, M, Wang, S, Ding, W, Lee, F-H, Okumura, M, Hraber, P, Overbaugh, J, Korber, B, Haynes, B, Hahn, B, and Shaw, G. "Molecular patterns of SHIV Env-Ab coevolution in rhesus macaques recapitulate HIV-1 Env-Ab co-evolution in humans infected by HIV-1 strains bearing homologous Envs." August 2017.

Scholars@Duke

Li, H, Williams, W, Bonsignori, M, Wang, S, Ding, W, Lee, F-H, Okumura, M, Hraber, P, Overbaugh, J, Korber, B, Haynes, B, Hahn, B, and Shaw, G. "Molecular patterns of SHIV Env-Ab coevolution in rhesus macaques recapitulate HIV-1 Env-Ab co-evolution in humans infected by HIV-1 strains bearing homologous envs." August 2017.

Scholars@Duke

Prévost, J, Zoubchenok, D, Richard, J, Veillette, M, Pacheco, B, Coutu, M, Brassard, N, Parsons, MS, Ruxrungtham, K, Bunupuradah, T, Tovanabutra, S, Hwang, K-K, Moody, MA, Haynes, BF, Bonsignori, M, Sodroski, J, Kaufmann, DE, Shaw, GM, Chenine, AL, and Finzi, A. "Influence of the Envelope gp120 Phe 43 Cavity on HIV-1 Sensitivity to Antibody-Dependent Cell-Mediated Cytotoxicity Responses." Journal of virology 91, no. 7 (April 2017).

PMID
28100618
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Bonsignori, M, Kreider, EF, Fera, D, Meyerhoff, RR, Bradley, T, Wiehe, K, Alam, SM, Aussedat, B, Walkowicz, WE, Hwang, K-K, Saunders, KO, Zhang, R, Gladden, MA, Monroe, A, Kumar, A, Xia, S-M, Cooper, M, Louder, MK, McKee, K, Bailer, RT, Pier, BW, Jette, CA, Kelsoe, G, Williams, WB, Morris, L, Kappes, J, Wagh, K, Kamanga, G, Cohen, MS, Hraber, PT, Montefiori, DC, Trama, A, Liao, H-X, Kepler, TB, Moody, MA, Gao, F, Danishefsky, SJ, Mascola, JR, Shaw, GM, Hahn, BH, Harrison, SC, and Korber, BT et al. "Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies." Science translational medicine 9, no. 381 (March 2017).

PMID
28298420
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Alam, SM, Aussedat, B, Vohra, Y, Meyerhoff, RR, Cale, EM, Walkowicz, WE, Radakovich, NA, Anasti, K, Armand, L, Parks, R, Sutherland, L, Scearce, R, Joyce, MG, Pancera, M, Druz, A, Georgiev, IS, Von Holle, T, Eaton, A, Fox, C, Reed, SG, Louder, M, Bailer, RT, Morris, L, Abdool-Karim, SS, Cohen, M, Liao, H-X, Montefiori, DC, Park, PK, Fernández-Tejada, A, Wiehe, K, Santra, S, Kepler, TB, Saunders, KO, Sodroski, J, Kwong, PD, Mascola, JR, Bonsignori, M, Moody, MA, Danishefsky, S, and Haynes, BF. "Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide." Science translational medicine 9, no. 381 (March 2017).

PMID
28298421
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Saunders, KO, Nicely, NI, Wiehe, K, Bonsignori, M, Meyerhoff, RR, Parks, R, Walkowicz, WE, Aussedat, B, Wu, NR, Cai, F, Vohra, Y, Park, PK, Eaton, A, Go, EP, Sutherland, LL, Scearce, RM, Barouch, DH, Zhang, R, Von Holle, T, Overman, RG, Anasti, K, Sanders, RW, Moody, MA, Kepler, TB, Korber, B, Desaire, H, Santra, S, Letvin, NL, Nabel, GJ, Montefiori, DC, Tomaras, GD, Liao, H-X, Alam, SM, Danishefsky, SJ, and Haynes, BF. "Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates." Cell reports 18, no. 9 (February 2017): 2175-2188.

PMID
28249163
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Bonsignori, M, Liao, H-X, Gao, F, Williams, WB, Alam, SM, Montefiori, DC, and Haynes, BF. "Antibody-virus co-evolution in HIV infection: paths for HIV vaccine development." Immunological reviews 275, no. 1 (January 2017): 145-160. (Review)

PMID
28133802
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