Mattia Bonsignori, MD

Associate Professor in Medicine
Member of the Duke Human Vaccine Institute
Campus mail 2 Genome Ct, Room 3013, MSRB II, Durham, NC 27710
Phone (919) 684-5858
Email address mattia.bonsignori@duke.edu

HIV vaccine development

Study of B-cell immune responses in HIV positive individuals

Determination of correlates of protective immunity to HIV

Induction of broadly neutralizing antibodies to HIV

Development of multiplex functional assays for the evaluation at a single-cell level of B-cell responses to vaccinations, infections and in vitro stimulation

Epidemiology and characterization of bacterial resistance determinants (past)

Education and Training

  • M.D., University of Insubria (Italy), 2001

Publications

Kisalu, NK, Idris, AH, Weidle, C, Flores-Garcia, Y, Flynn, BJ, Sack, BK, Murphy, S, Schön, A, Freire, E, Francica, JR, Miller, AB, Gregory, J, March, S, Liao, H-X, Haynes, BF, Wiehe, K, Trama, AM, Saunders, KO, Gladden, MA, Monroe, A, Bonsignori, M, Kanekiyo, M, Wheatley, AK, McDermott, AB, Farney, SK, Chuang, G-Y, Zhang, B, Kc, N, Chakravarty, S, Kwong, PD, Sinnis, P, Bhatia, SN, Kappe, SHI, Sim, BKL, Hoffman, SL, Zavala, F, Pancera, M, and Seder, RA. "Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite." Nature Medicine 25, no. 1 (January 2019): 188-189.

PMID
30552419
Full Text

Bricault, CA, Yusim, K, Seaman, MS, Yoon, H, Theiler, J, Giorgi, EE, Wagh, K, Theiler, M, Hraber, P, Macke, JP, Kreider, EF, Learn, GH, Hahn, BH, Scheid, JF, Kovacs, JM, Shields, JL, Lavine, CL, Ghantous, F, Rist, M, Bayne, MG, Neubauer, GH, McMahan, K, Peng, H, Chéneau, C, Jones, JJ, Zeng, J, Ochsenbauer, C, Nkolola, JP, Stephenson, KE, Chen, B, Gnanakaran, S, Bonsignori, M, Williams, LD, Haynes, BF, Doria-Rose, N, Mascola, JR, Montefiori, DC, Barouch, DH, and Korber, B. "HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design." Cell Host & Microbe 25, no. 1 (January 2019): 59-72.e8.

PMID
30629920
Full Text

Bonsignori, M, Scott, E, Wiehe, K, Easterhoff, D, Alam, SM, Hwang, K-K, Cooper, M, Xia, S-M, Zhang, R, Montefiori, DC, Henderson, R, Nie, X, Kelsoe, G, Moody, MA, Chen, X, Joyce, MG, Kwong, PD, Connors, M, Mascola, JR, McGuire, AT, Stamatatos, L, Medina-Ramírez, M, Sanders, RW, Saunders, KO, Kepler, TB, and Haynes, BF. "Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier." Immunity 49, no. 6 (December 11, 2018): 1162-1174.e8.

PMID
30552024
Full Text

Andrabi, R, Jiang, C, Zhang, J, Newman, A, Song, G, Pallesen, J, Gegg, G, Su, C-Y, de Val, N, Bouton-Vervelle, H, Armand, L, Bonsignori, M, Cooper, M, Venturi, G, Kelsoe, G, Ward, A, Haynes, B, Burton, D, and Verkoczy, L. "Vaccine Induction of V2 Apex-directed, Cross-reactive Neutralizing Antibodies in CH01 UCA "HC Only" Knock-in Mice." HIV Research for Prevention Meeting (HIVR4P) - AIDS Vaccine, Microbicide and ARV-Based Prevention Science. Madrid, SPAIN. October 21, 2018 - October 25, 2018.: MARY ANN LIEBERT, INC, October 1, 2018.

Scholars@Duke

Wiehe, K, Saunders, KO, Bradley, T, Faison, WJ, Hart, C, Bowman, C, Trama, A, Hernandez, G, Lee, E, Reed, R, Chen, H, Alam, SM, Bonsignori, M, Tian, M, Alt, FW, and Haynes, BF. "Targeted Selection of an Improbable HIV-1 Antibody Mutation Critical for Broadly Neutralizing Reactivity With a Designed Immunogen." HIV Research for Prevention Meeting (HIVR4P) - AIDS Vaccine, Microbicide and ARV-Based Prevention Science. Madrid, SPAIN. October 21, 2018 - October 25, 2018.: MARY ANN LIEBERT, INC, October 1, 2018.

Scholars@Duke

Li, H, Roark, R, Wang, S, Lee, F-H, Ding, W, Murphy, A, Rando, J, Rosario, C, Ding, Y, Zhao, C, Williams, W, Bonsignori, M, Saunders, K, Haynes, B, Hahn, B, and Shaw, G. "New SHIV Models of bNAb Elicitation and Env-Ab Coevolution." HIV Research for Prevention Meeting (HIVR4P) - AIDS Vaccine, Microbicide and ARV-Based Prevention Science. Madrid, SPAIN. October 21, 2018 - October 25, 2018.: MARY ANN LIEBERT, INC, October 1, 2018.

Scholars@Duke

Behrens, S, LaBranche, CC, Zhou, T, Wiehe, K, Bonsignori, M, Sattentau, QJ, Eaton, A, Greene, K, Gao, H, Williams, WB, Saunders, K, Perez, LG, Korber, BT, Kwong, PD, Mascola, JR, McGuire, AT, Stamatatos, L, Acharya, P, Haynes, BF, and Montefiori, DC. "Germline-targeting and Reverse Engineering to Elicit CH235.12 Lineage bNAbs." HIV Research for Prevention Meeting (HIVR4P) - AIDS Vaccine, Microbicide and ARV-Based Prevention Science. Madrid, SPAIN. October 21, 2018 - October 25, 2018.: MARY ANN LIEBERT, INC, October 1, 2018.

Scholars@Duke

Bonsignori, M, Scott, E, Wiehe, K, Easterhoff, D, Alam, SM, Hwang, K-K, Montefiori, DC, Henderson, R, Chen, X, Joyce, MG, Kwong, PD, Connors, M, Mascola, JR, McGuire, AT, Stamatatos, L, Medina-Ramirez, M, Sanders, RW, Saunders, KO, Kepler, TB, and Haynes, BF. "Dual Maturation Pathways from the Unmutated Common Ancestor of HIV-1 Envelope Broadly Neutralizing Antibodies Overcome Glycan Barriers." HIV Research for Prevention Meeting (HIVR4P) - AIDS Vaccine, Microbicide and ARV-Based Prevention Science. Madrid, SPAIN. October 21, 2018 - October 25, 2018.: MARY ANN LIEBERT, INC, October 1, 2018.

Scholars@Duke

Williams, WB, Meyerhoff, RR, Li, H, Acharya, P, Stewart-Jones, GBE, Wiehe, K, Kepler, TB, Bradley, T, Bonsignori, M, Moody, MA, Saunders, KO, Santra, S, Kelsoe, G, Hraber, P, Korber, B, Hahn, BH, Kwong, P, Mascola, JR, Shaw, GM, and Haynes, BF. "Macaque SHIV Induction of 2G12-like Broadly Neutralizing Antibodies." HIV Research for Prevention Meeting (HIVR4P) - AIDS Vaccine, Microbicide and ARV-Based Prevention Science. Madrid, SPAIN. October 21, 2018 - October 25, 2018.: MARY ANN LIEBERT, INC, October 1, 2018.

Scholars@Duke

Wiehe, K, Bradley, T, Meyerhoff, RR, Hart, C, Williams, WB, Easterhoff, D, Faison, WJ, Kepler, TB, Saunders, KO, Alam, SM, Bonsignori, M, and Haynes, BF. "Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development." Cell Host & Microbe 23, no. 6 (June 2018): 759-765.e6.

PMID
29861171
Full Text

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