Mattia Bonsignori, MD

Associate Professor in Medicine
Member of the Duke Human Vaccine Institute
Campus mail 2 Genome Ct, Room 3013, MSRB II, Durham, NC 27710
Phone (919) 684-5858
Email address mattia.bonsignori@duke.edu

HIV vaccine development

Study of B-cell immune responses in HIV positive individuals

Determination of correlates of protective immunity to HIV

Induction of broadly neutralizing antibodies to HIV

Development of multiplex functional assays for the evaluation at a single-cell level of B-cell responses to vaccinations, infections and in vitro stimulation

Epidemiology and characterization of bacterial resistance determinants (past)

Education and Training

  • M.D., University of Insubria (Italy), 2001

Publications

Kisalu, NK, Idris, AH, Weidle, C, Flores-Garcia, Y, Flynn, BJ, Sack, BK, Murphy, S, Schön, A, Freire, E, Francica, JR, Miller, AB, Gregory, J, March, S, Liao, H-X, Haynes, BF, Wiehe, K, Trama, AM, Saunders, KO, Gladden, MA, Monroe, A, Bonsignori, M, Kanekiyo, M, Wheatley, AK, McDermott, AB, Farney, SK, Chuang, G-Y, Zhang, B, Kc, N, Chakravarty, S, Kwong, PD, Sinnis, P, Bhatia, SN, Kappe, SHI, Sim, BKL, Hoffman, SL, Zavala, F, Pancera, M, and Seder, RA. "A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite. (Accepted)" Nature medicine 24, no. 4 (May 2018): 408-416.

PMID
29554083
Full Text

Wills, S, Hwang, K-K, Liu, P, Dennison, SM, Tay, MZ, Shen, X, Pollara, J, Lucas, JT, Parks, R, Rerks-Ngarm, S, Pitisuttithum, P, Nitayapan, S, Kaewkungwal, J, Thomas, R, Kim, JH, Michael, NL, Robb, ML, McRaven, M, Montefiori, DC, Hope, TJ, Liao, H-X, Moody, MA, Ferrari, G, Haynes, BF, Alam, SM, Bonsignori, M, and Tomaras, GD. "HIV-1-Specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galactosylceramide Blocking and Phagocytosis." Journal of virology 92, no. 7 (April 2018).

PMID
29321320
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Fera, D, Lee, MS, Wiehe, K, Meyerhoff, RR, Piai, A, Bonsignori, M, Aussedat, B, Walkowicz, WE, Ton, T, Zhou, JO, Danishefsky, S, Haynes, BF, and Harrison, SC. "HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope." Nature communications 9, no. 1 (March 16, 2018): 1111-.

PMID
29549260
Full Text

Cheng, HD, Grimm, SK, Gilman, MS, Gwom, LC, Sok, D, Sundling, C, Donofrio, G, Hedestam, GBK, Bonsignori, M, Haynes, BF, Lahey, TP, Maro, I, von Reyn, CF, Gorny, MK, Zolla-Pazner, S, Walker, BD, Alter, G, Burton, DR, Robb, ML, Krebs, SJ, Seaman, MS, Bailey-Kellogg, C, and Ackerman, ME. "Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site." JCI insight 3, no. 5 (March 8, 2018).

PMID
29515029
Full Text

Hurwitz, JL, and Bonsignori, M. "Multi-Envelope HIV-1 Vaccine Development: Two Targeted Immune Pathways, One Desired Protective Outcome." Viral immunology 31, no. 2 (March 2018): 124-132.

PMID
29315059
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Saunders, KO, Verkoczy, LK, Jiang, C, Zhang, J, Parks, R, Chen, H, Housman, M, Bouton-Verville, H, Shen, X, Trama, AM, Scearce, R, Sutherland, L, Santra, S, Newman, A, Eaton, A, Xu, K, Georgiev, IS, Joyce, MG, Tomaras, GD, Bonsignori, M, Reed, SG, Salazar, A, Mascola, JR, Moody, MA, Cain, DW, Centlivre, M, Zurawski, S, Zurawski, G, Erickson, HP, Kwong, PD, Alam, SM, Levy, Y, Montefiori, DC, and Haynes, BF. "Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models." Cell reports 21, no. 13 (December 2017): 3681-3690.

PMID
29281818
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Williams, WB, Zhang, J, Jiang, C, Nicely, NI, Fera, D, Luo, K, Moody, MA, Liao, H-X, Alam, SM, Kepler, TB, Ramesh, A, Wiehe, K, Holland, JA, Bradley, T, Vandergrift, N, Saunders, KO, Parks, R, Foulger, A, Xia, S-M, Bonsignori, M, Montefiori, DC, Louder, M, Eaton, A, Santra, S, Scearce, R, Sutherland, L, Newman, A, Bouton-Verville, H, Bowman, C, Bomze, H, Gao, F, Marshall, DJ, Whitesides, JF, Nie, X, Kelsoe, G, Reed, SG, Fox, CB, Clary, K, Koutsoukos, M, Franco, D, Mascola, JR, and Harrison, SC et al. "Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations." Nature communications 8, no. 1 (November 23, 2017): 1732-.

PMID
29170366
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Yu, J-S, Liao, H-X, Pritchett, J, Bowman, C, Vivian, C, Parks, R, Xia, S-M, Cooper, M, Williams, WB, Bonsignori, M, Reed, SG, Chen, M, Vandergrift, N, Rice, CM, and Haynes, BF. "Development of a recombinant yellow fever vector expressing a HIV clade C founder envelope gp120." Journal of virological methods 249 (November 2017): 85-93.

PMID
28837840
Full Text

Hwang, JK, Wang, C, Du, Z, Meyers, RM, Kepler, TB, Neuberg, D, Kwong, PD, Mascola, JR, Joyce, MG, Bonsignori, M, Haynes, BF, Yeap, L-S, and Alt, FW. "Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies." Proceedings of the National Academy of Sciences of the United States of America 114, no. 32 (August 2017): 8614-8619.

PMID
28747530
Full Text

Li, H, Williams, W, Bonsignori, M, Wang, S, Ding, W, Lee, F-H, Okumura, M, Hraber, P, Overbaugh, J, Korber, B, Haynes, B, Hahn, B, and Shaw, G. "Molecular patterns of SHIV Env-Ab coevolution in rhesus macaques recapitulate HIV-1 Env-Ab co-evolution in humans infected by HIV-1 strains bearing homologous Envs." August 2017.

Scholars@Duke

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