Megan Elizabeth Bowles Clowse, MD

Associate Professor of Medicine
Campus mail Baker House 07, Duke South, Trent Drive, Durham, NC 27710
Phone (919) 681-2045
Email address megan.clowse@duke.edu

I am a clinical researcher with a focus on the management of rheumatologic diseases in pregnancy.  Since 2007, I have collected prospective pregnancies in women with rheumatic disease in the Duke Autoimmunity in Pregnancy Registry, which currently includes over 300 pregnancies.  This registry includes clinical data, pregnancy outcomes, and a large sample repository.  In collaboration with Duke Pediatric Cardiology, we found that maternal use of hydroxychloroquine may be protective against congenital heart block from neonatal lupus.  I have also conducted studies on vasculitis and ovarian function and pregnancy and I am the director of the Vasculitis-Pregnancy Registry, through the Vasculitis Clinical Research Consortium, is an online pregnancy registry for women with these rare conditions.  I am starting a study to identify causes for the high rate of infertility among women with rheumatoid arthrits.  I am also working on several projects to better understand how psoriatic arthritis impacts pregnancy.  

In Their Words

Education and Training

  • Fellow in Rheumatology, Medicine, Johns Hopkins University, 2002 - 2005
  • Medical Residetn, Medicine, Johns Hopkins University, 1999 - 2002
  • M.D., Vanderbilt University, 1999
  • M.P.H., University of California at Los Angeles, 1994

Publications

Provost, M, Eaton, JL, and Clowse, MEB. "Fertility and infertility in rheumatoid arthritis." Current opinion in rheumatology 26, no. 3 (May 2014): 308-314. (Review)

PMID
24663108
Full Text

Bonsignori, M, Wiehe, K, Grimm, SK, Lynch, R, Yang, G, Kozink, DM, Perrin, F, Cooper, AJ, Hwang, K-K, Chen, X, Liu, M, McKee, K, Parks, RJ, Eudailey, J, Wang, M, Clowse, M, Criscione-Schreiber, LG, Moody, MA, Ackerman, ME, Boyd, SD, Gao, F, Kelsoe, G, Verkoczy, L, Tomaras, GD, Liao, H-X, Kepler, TB, Montefiori, DC, Mascola, JR, and Haynes, BF. "An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1." The Journal of clinical investigation 124, no. 4 (April 2014): 1835-1843.

PMID
24614107
Full Text

Wasserman, S, and Clowse, MEB. "Systemic lupus erthematosus." (March 1, 2014): 79-97. (Chapter)

Full Text

Peart, E, and Clowse, MEB. "Systemic lupus erythematosus and pregnancy outcomes: an update and review of the literature." Current opinion in rheumatology 26, no. 2 (March 2014): 118-123. (Review)

PMID
24419751
Full Text

Mahadevan, U, Vermeire, S, Wolf, D, Forger, F, Cush, J, Golembesky, A, Shaughnessy, L, De Cuyper, D, and Abbas, S. "DOP024 Pregnancy outcomes after exposure to certolizumab pegol: Results from safety surveillance." Journal of Crohn's and Colitis 8 (February 2014): S26-S26.

Full Text

Chakravarty, E, Clowse, MEB, Pushparajah, DS, Mertens, S, and Gordon, C. "Family planning and pregnancy issues for women with systemic inflammatory diseases: patient and physician perspectives." BMJ open 4, no. 2 (January 2014): e004081-.

PMID
24500612
Full Text

Schramm, AM, and Clowse, MEB. "Aspirin for prevention of preeclampsia in lupus pregnancy." Autoimmune diseases 2014 (January 2014): 920467-. (Review)

PMID
24778868
Full Text

Peart, E, and Clowse, MEB. "Systemic lupus erythematosus and pregnancy outcomes: An update and review of the literature." Current Opinion in Rheumatology 26, no. 2 (2014): 118-123.

Full Text

Chakravarty, E, Clowse, MEB, Pushparajah, DS, Mertens, S, and Gordon, C. "Family planning and pregnancy issues for women with systemic inflammatory diseases: Patient and physician perspectives." BMJ Open 4, no. 2 (2014).

Full Text

Chaudhary, P, and Clowse, MEB. "Prednisone Use Associated With Worse Outcomes In Rheumatoid Arthritis Pregnancies." October 2013.

Scholars@Duke

Pages