Rheumatology and Immunology

Megan Elizabeth Bowles Clowse, MD

Associate Professor of Medicine
Campus mail Baker House 07, Duke South, Trent Drive, Durham, NC 27710
Phone (919) 681-2045
Email address megan.clowse@duke.edu

I am a clinical researcher with a focus on the management of rheumatologic diseases in pregnancy.  Since 2007, I have collected prospective pregnancies in women with rheumatic disease in the Duke Autoimmunity in Pregnancy Registry, which currently includes over 300 pregnancies.  This registry includes clinical data, pregnancy outcomes, and a large sample repository.  In collaboration with Duke Pediatric Cardiology, we found that maternal use of hydroxychloroquine may be protective against congenital heart block from neonatal lupus.  I have also conducted studies on vasculitis and ovarian function and pregnancy and I am the director of the Vasculitis-Pregnancy Registry, through the Vasculitis Clinical Research Consortium, is an online pregnancy registry for women with these rare conditions.  I am starting a study to identify causes for the high rate of infertility among women with rheumatoid arthrits.  I am also working on several projects to better understand how psoriatic arthritis impacts pregnancy.  

In Their Words

Education and Training

  • Fellow in Rheumatology, Medicine, Johns Hopkins University, 2002 - 2005
  • Medical Residetn, Medicine, Johns Hopkins University, 1999 - 2002
  • M.D., Vanderbilt University, 1999
  • M.P.H., University of California at Los Angeles, 1994

Grants

Publications

Kurakula, P, Somers, TJ, Criscione-Schreiber, LG, Keefe, FJ, and Clowse, MEB. "The Relationship Between Pain Coping Skills and Pain, Fatigue, Mood, and Lupus Activity." October 2011.

Scholars@Duke

Clowse, MEB, Criscione-Schreiber, LG, and Pisetsky, DS. "Predictors of Preterm Birth and Preeclampsia in Systemic Lupus Erythematosus." October 2011.

Scholars@Duke

Harward, LE, Mitchell, K, Criscione-Schreiber, LG, and Clowse, MEB. "Few Pregnancies After Cyclophosphamide Treatment Despite Preserved Ovarian Function." October 2011.

Scholars@Duke

Clowse, MEB, Richesson, R, Pieper, C, Merkel, PA, and Consortium, VCR. "Pregnancy in Men and Women with Vasculitis." October 2011.

Scholars@Duke

Clowse, MEB, Chakravarty, EF, Costenbader, KH, Chambers, C, Wolfe, F, and Michaud, K. "Contraception Use in Women with Rheumatoid Arthritis." October 2011.

Scholars@Duke

Clowse, MEB, Criscione-Schreiber, LG, Jolly, M, Keefe, FJ, and Somers, TJ. "Memory Complaints in Lupus Patients: Relationship to Lupus Activity, Symptoms, Quality of Life, Psychological Distress, and Coping." October 2011.

Scholars@Duke

Clowse, MEB, Magder, LS, and Petri, M. "The clinical utility of measuring complement and anti-dsDNA antibodies during pregnancy in patients with systemic lupus erythematosus." J Rheumatol 38, no. 6 (June 2011): 1012-1016.

PMID
21406496
Full Text

Ullal, AJ, Reich, CF, Clowse, M, Criscione-Schreiber, LG, Tochacek, M, Monestier, M, and Pisetsky, DS. "Microparticles as antigenic targets of antibodies to DNA and nucleosomes in systemic lupus erythematosus." Journal of Autoimmunity 36, no. 3-4 (May 2011): 173-180.

PMID
21376534
Full Text

Crochet, JR, Yeh, JS, Clowse, MEB, and Copland, SD. "Late ovarian hyperstimulation syndrome after controlled ovarian stimulation in a woman with systemic lupus erythematosus and lupus nephritis." Fertil Steril 95, no. 5 (April 2011): 1786.e13-1786.e16.

PMID
21168129
Full Text

Copland, SC, and Clowse, M. "Use of gnrh agonists for prevention of chemotherapy-induced gonadotoxicity." (January 1, 2011): 239-249. (Chapter)

Full Text

Pages