Megan Elizabeth Bowles Clowse, MD

Associate Professor of Medicine
Campus mail Baker House 07, Duke South, Trent Drive, Durham, NC 27710
Phone (919) 681-2045
Email address megan.clowse@duke.edu

I am a clinical researcher with a focus on the management of rheumatologic diseases in pregnancy.  Since 2007, I have collected prospective pregnancies in women with rheumatic disease in the Duke Autoimmunity in Pregnancy Registry, which currently includes over 300 pregnancies.  This registry includes clinical data, pregnancy outcomes, and a large sample repository.  In collaboration with Duke Pediatric Cardiology, we found that maternal use of hydroxychloroquine may be protective against congenital heart block from neonatal lupus.  I have also conducted studies on vasculitis and ovarian function and pregnancy and I am the director of the Vasculitis-Pregnancy Registry, through the Vasculitis Clinical Research Consortium, is an online pregnancy registry for women with these rare conditions.  I am starting a study to identify causes for the high rate of infertility among women with rheumatoid arthrits.  I am also working on several projects to better understand how psoriatic arthritis impacts pregnancy.  

In Their Words

Education and Training

  • Fellow in Rheumatology, Medicine, Johns Hopkins University, 2002 - 2005
  • Medical Residetn, Medicine, Johns Hopkins University, 1999 - 2002
  • M.D., Vanderbilt University, 1999
  • M.P.H., University of California at Los Angeles, 1994

Publications

Clowse, MEB, Criscione-Schreiber, LG, Jolly, M, Keefe, FJ, and Somers, TJ. "Memory Complaints in Lupus Patients: Relationship to Lupus Activity, Symptoms, Quality of Life, Psychological Distress, and Coping." October 2011.

Scholars@Duke

Clowse, MEB, Magder, LS, and Petri, M. "The clinical utility of measuring complement and anti-dsDNA antibodies during pregnancy in patients with systemic lupus erythematosus." J Rheumatol 38, no. 6 (June 2011): 1012-1016.

PMID
21406496
Full Text

Ullal, AJ, Reich, CF, Clowse, M, Criscione-Schreiber, LG, Tochacek, M, Monestier, M, and Pisetsky, DS. "Microparticles as antigenic targets of antibodies to DNA and nucleosomes in systemic lupus erythematosus." J Autoimmun 36, no. 3-4 (May 2011): 173-180.

PMID
21376534
Full Text

Crochet, JR, Yeh, JS, Clowse, MEB, and Copland, SD. "Late ovarian hyperstimulation syndrome after controlled ovarian stimulation in a woman with systemic lupus erythematosus and lupus nephritis." Fertil Steril 95, no. 5 (April 2011): 1786.e13-1786.e16.

PMID
21168129
Full Text

Copland, SC, and Clowse, M. "Use of gnrh agonists for prevention of chemotherapy-induced gonadotoxicity." (January 1, 2011): 239-249. (Chapter)

Full Text

Clowse, ME. "The use of anti-TNFα medications for rheumatologic disease in pregnancy. (Published online)" Int J Womens Health 2 (August 9, 2010): 199-209.

PMID
21072312
Scholars@Duke

Clowse, MEB, Petri, M, and James, AH. "Rheumatologic Disorders in Pregnancy." (July 9, 2010): 209-232. (Chapter)

Full Text

Clowse, MEB. "Managing contraception and pregnancy in the rheumatologic diseases." Best Pract Res Clin Rheumatol 24, no. 3 (June 2010): 373-385. (Review)

PMID
20534371
Full Text

Mitchell, K, Kaul, M, and Clowse, MEB. "The management of rheumatic diseases in pregnancy." Scand J Rheumatol 39, no. 2 (March 2010): 99-108. (Review)

PMID
20337545
Full Text

Clowse, MEB, and Ramsey-Goldman, R. "Pregnancy in the rheumatic diseases." (December 1, 2009): 181-190. (Chapter)

Full Text

Pages