Megan Elizabeth Bowles Clowse, MD

Associate Professor of Medicine
Campus mail Baker House 07, Duke South, Trent Drive, Durham, NC 27710
Phone (919) 681-2045
Email address megan.clowse@duke.edu

Dr. Megan Clowse is an Associate Professor of Medicine in the Division of Rheumatology and Immunology.  Her clinical research focuses on the management of rheumatic diseases in pregnancy. She has cared for over 600 pregnancies in women with rheumatic disease, collecting information on these pregnancies initially in the Duke Autoimmunity in Pregnancy Registry and Repository, and now the MADRA (Maternal Autoimmune Disease Research Alliance) registry and repository.  She served on the Core Leadership Team for the inaugural American College of Rheumatology's Reproductive Health Guidelines, published January 2020.  Dr. Clowse created www.LupusPregnancy.org, a website dedicated to improving lupus pregnancy planning and management for patients and rheumatologists.  

Dr. Clowse was the founding director of the Duke Lupus Clinic, where she continues to see patients each week and mentor junior faculty researchers.  The team has developed a new approach to lupus classification and management and is currently collecting and analyzing patient- and physician-reported measures to  better clarify this construct.  

As the Co-Director of Duke Forge, Dr. Clowse has shepherding multiple Department of Medicine-funded studies to identify and build innovative approaches to using health data to improve patient care. 

In Their Words

Education and Training

  • Fellow in Rheumatology, Medicine, Johns Hopkins University, 2002 - 2005
  • Medical Residetn, Medicine, Johns Hopkins University, 1999 - 2002
  • M.D., Vanderbilt University, 1999
  • M.P.H., University of California - Los Angeles, 1994

Publications

Clowse, M. E. B., G. McDaniel, and A. M. Eudy. “SAT0466 Pregnancy in women with psoriatic arthritis: pregnancy outcomes and changes in disease activity.” In Poster Presentations. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. https://doi.org/10.1136/annrheumdis-2017-eular.6392.

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Clowse, M. E. B., F. Förger, C. Hwang, J. Thorp, R. J. E. M. Dolhain, A van Tubergen, L. Shaughnessy, et al. “FRI0179 Minimal to no transfer of certolizumab pegol into breast milk: results from cradle, a prospective, postmarketing, multicenter, pharmacokinetic study.” In Poster Presentations. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. https://doi.org/10.1136/annrheumdis-2017-eular.2467.

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Clowse, M. E. B. “Case Study: Lupus in Pregnancy.” In Birth Defects Research, 109:633–633. WILEY, 2017.

Scholars@Duke

Clowse, M. E. B. “Overview: Complexity of Disease Management in Pregnancy and Lactation, Consequences of Chronic Disease Itself and Polypharmacy, Use of Asthma and Lupus As Examples.” In Birth Defects Research, 109:633–633. WILEY, 2017.

Scholars@Duke

Eudy, A. M., A. M. Siega-Riz, S. M. Engel, N. Franceschini, A. G. Howard, M. E. B. Clowse, and M. Petri. “Gestational weight gain in women with systemic lupus erythematosus.” Lupus 26, no. 6 (May 2017): 623–32. https://doi.org/10.1177/0961203316671811.

PMID
27703053
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Clowse, Megan E. B., Daniel J. Wallace, Richard A. Furie, Michelle A. Petri, Marilyn C. Pike, Piotr Leszczyński, C Michael Neuwelt, et al. “Efficacy and Safety of Epratuzumab in Moderately to Severely Active Systemic Lupus Erythematosus: Results From Two Phase III Randomized, Double-Blind, Placebo-Controlled Trials.” Arthritis Rheumatol 69, no. 2 (February 2017): 362–75. https://doi.org/10.1002/art.39856.

PMID
27598855
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Thorp, John, Megan E. B. Clowse, Frauke Förger, Caroline Hwang, Radboud J. E. M. Dolhain, Astrid van Tubergen, Laura Shaughnessy, et al. “692: Evaluating transfer of certolizumab pegol into breast milk: results from a prospective, postmarketing, multicenter pharmacokinetic study.” In American Journal of Obstetrics and Gynecology, 216:S405–6. Elsevier BV, 2017. https://doi.org/10.1016/j.ajog.2016.11.426.

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